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| 1 | Helicobacter pylori infection and micronutrient deficiencies显示文摘It is known that deficiencies of micronutrients due to infections increase morbidity and mortality. This phenomenon depicts itself conspicuously in developing countries.Deficiencies of iron, vitamins A, E, C, B12, etc are widely prevalent among populations living in the third world countries. Helicobacterpylori (Hpylori) infection has a high prevalence throughout the world. Deficiencies of several micronutrients due to Hpylori infection may be concomitantly present and vary from subtle sub-clinical states to severe clinical disorders. These essential trace elementsl micronutrients are involved in host defense mechanisms,maintaining epithelial cell integrity, glycoprotein synthesis,transport mechanisms, myocardial contractility, brain development, cholesterol and glucose metabolism. In this paper Hpyloriinfection in associaed with various micronutrients deficiencies is briefly reviewed. | Javed Yakoob Wasim Jafri Shahab Abid | 2003 | World Journal of Gastroenterology2003，9，10： | 7 |
| 2 | Prevalence of non-Helicobacter pylori duodenal ulcer in Karachi,Pakistan显示文摘AIM: To determine the prevalence of non-Helicobacter pylori (H pylori)-related duodenal ulcer in patients with acid-peptic diseases.METHODS: Medical records of patients who attended the Gastroenterology Department at Aga Khan University Hospital from 1999 to 2001 and had endoscopic diagnosis of duodenal ulcers were reviewed. Duodenal ulcer associated with H pylori was diagnosed on the basis of endoscopy,rapid urease test and histopathology whereas histories of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) related duodenal ulcers. Non-H pylori, non-NSAID duodenal ulcers were those without H pylori infection and history of NSAID intake. Co-morbid conditions associated were noted.RESULTS: Of 2 260 patients, 10% (217/2 260) had duodenal ulcer. Duodenal ulcer related to H pylori infectionaccounted for 53% (116/217), NSAID-related 10% (22/217),non-H pylori non-NSAID 29% (62/217), and 8% (17/217) had both Hpyloriinfection and histories of NSAID intake. Fifteen percent (18/116)_patients had past histories of peptic ulcer disease in Hpyloriinfection, while 8% (5/62) in non-Hpylorinon-NSAID ulcer. Co-morbid conditions in H pylori infection were seen in 23% (27/116) and 34%(21/62) in non-H pylori non-NSAID ulcer.CONCLUSION: Incidence of H pylori infection related with duodenal ulcer is common. In the presence of co-morbids, non-Hpyloriand non-NSAID duodenal ulcer is likely to be present. | Javed Yakoob Wasim Jafri Nadim Jafri Muhammad Islam Shahab Abid Saeed Hamid Hasnain AliShah Hizbullah Shaikh | 2005 | World Journal of Gastroenterology2005，11，23： | 6 |
| 3 | Telomere,telomerase and digestive cancer显示文摘Recentadvancessuggestthattelomeraseisasociatedwithcelularimmortalitywhichisahalmarkofcancer.TELOMERESHumantelomerescontainana... | Javed Yakoob, HU Guo Ling, FAN Xue Gong and ZHANG Zheng | 1999 | World Journal of Gastroenterology1999，5，4： | 5 |
| 4 | Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitors显示文摘AIM: To determine the efficacy of gastric juice polymerase chain reaction (PCR) for the detection of H pylori infection in comparison with histology and gastric antral biopsy PCR in patients on a proton pump inhibitor (PPI). METHODS: Eighty-five consecutive patients with dyspeptic symptoms were enrolled. Gastric biopsies for histology, PCR and gastric juice were collected at endoscopy for PCR of the H pylori urease C gene (ure C). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy, positive and negative likelihood ratio for PCR of gastric juice for the H pylori ure C gene was compared to histology and gastric antral biopsy H pylori ure C PCR in patients with and without PPI. RESULTS: Gastric juice PCR was positive in 66 (78%) patients. Histology showed H pylori associated gastritis in 57 (67%). Gastric biopsy PCR was positive in 72 (85%). In patients not taking PPI, the sensitivity, specificity, PPV, NPV, accuracy and positive and negative likelihood ratio for gastric juice PCR were 89%, 72%, 91%, 67%, 90%, 85%, 3.1 and 0.1 respectively. In patients on PPI these values were 86%, 100%%, 100%, 29%, 86%, 9.5 and 1.4, respectively. CONCLUSION: Gastric juice PCR for the diagnosis of H pylori infection has increased sensitivity compared to histology with PPI. The use of gastric juice PCR is recommended to confirm H pylori status in patients taking PPIs. | Javed Yakoob Shahid Rasool Zaigham Abbas Wasim Jafri Shahab Abid Muhammad Islam Zubair Ahmad | 2008 | World Journal of Gastroenterology2008，14，10： | 4 |
| 5 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 6 | Candida esophagitis:Risk factors in non-HIV population in Pakistan显示文摘AIM:Candida esophagitis is a frequent infection in immunocompromised patients. This study was designed to determine its characteristics in non- human immune deficiency virus (HIV) infected patients attending a teaching hospital.METHODS: Clinical records of all patients coded by international classification of diseases 9th revision with clinical modifications'(ICD-9-CM), with candida esophagitis diagnosed by esophagogastroduodenoscopy (EGD) and histopathology over a period of 5 years were studied.RESULTS: Fifty-one patients (27 males, 24 females, range 21-77 years old and mean age 52.9 years) fulfilled the criteria (0.34% of the EGD). The common predisposing factors were carcinoma (OR 3.87, CI 1.00-14.99) and diabetes mellitus (OR 4.39, CI 1.34-14.42). The frequent clinical symptoms were retrosternal discomfort, dysphagia and epigastric abdominal pain with endoscopic appearance of scattered mucosal plaques. Another endoscopic lesion was associated with candida esophagitis in 15% patients.CONCLUSION: Carcinomas, diabetes mellitus, corticosteroid and antibiotic therapy are major risk factors for candida esophagitis in Pakistan. It is an easily managed complication that responds to treatment with nystatin. | Javed Yakoob Wasim Jafri Shahab Abid Nadeem Jafri Muhammad Islam Saeed Hamid Hasnain A Shah Akbar S Hussainy | 2003 | World Journal of Gastroenterology2003，9，10： | 2 |
| 7 | Elevated circulating levels of serum tumor necrosis factor- alpha in patients with hemodynamically significant pressure and volume overload显示文摘 | Kapadia SR Yakoob K Nader S | 2000 | J Am Coll Cardiol2000，36，1： | 2 |
| 8 | Effect of routine iron supplementation withor without folic acid on anemia during pregnancy显示文摘 | Yakoob MY Bhutta ZA | 2011 | BMC PublicHealth2011，113，： | 1 |
| 9 | Enhanced T-helper 2 lymphocyte responses: immunemechanism of Helicobacter pylori infection显示文摘 | Fan XG Yakoob J Fan XJ | 1996 | Ir J Med Sci1996，165，： | 1 |
| 10 | Irritable bowel syn- drome : in search of an etiology : role of Blastocystis hom- inis显示文摘 | Yakoob J Jafri W Jafri N | 2004 | Am J Trop Med Hyg2004，70，4： | 1 |
| 11 | Irritable bowel syndrome: in search of an etiology:role of Blastocystis horn inis显示文摘 | Yakoob J Jafri W Jafri N | 2004 | Am J Trop Med Hyg2004，70，4： | 1 |
| 12 | In vitro susceptibility of Blastocystis hominis isolated from patients with irritable bowel syndrome 显示文摘 | Yakoob J Jafri W Jafri N | 2004 | Br J Biomed Sci2004，61，2： | 1 |
| 13 | Cytokine and clinical response to Saccharomyces boulardii therapy in diarrhea-dominant irritable bowel syndrome: a randomized trial 显示文摘 | Abbas Z Yakoob J Jafri W | 2014 | Gastroenterol Hepatol2014，26，6： | 1 |
| 14 | Comparison of the vir- ulence markers of Helicobacter pylori and their associat- ed diseases in patients from Pakistan and Afghanistan显示文摘 | Yakoob J Abbas Z Jafri W | 2013 | Saudi J Gastroenterol2013，19，5： | 1 |
| 15 | Impact of vi-tamin A supplementation on infant and childhoodmortality 显示文摘 | Imdad A Yakoob MY Sudfeld C | 2011 | BMC Public Health2011，11，3： | 1 |
| 16 | Effect of Helicobacter pylori and its virulence factors on portal hypertensive gastropathy and interleukin(IL)-8,IL-10,and tumor necrosis factor-alpha levels显示文摘 | ABBAS Z YAKOOB J USMAN M W | 2014 | Saudi J Gastroenterol2014，20，： | 1 |
| 17 | Irritable bowel syndrome: is it associated with genotypes of Blastocystis hominis 显示文摘 | Yakoob J Jafri W Beg MA | 2010 | Parasitol Res2010，106，5： | 1 |
| 18 | Perception of gastroesopha- geal reflux disease in urban population in Pakistan显示文摘 | Jafri N Jafri W Yakoob J | 2005 | Coil Physicians Surg Pak2005，15，9： | 1 |
| 19 | Helicobacter pylori induce lipid peroxidation in peripheral blood lymphocytes显示文摘 | Fan XG Yakoob J Chua A | 1995 | APMIS1995，103，： | 1 |
| 20 | Impact of maternal educa- tion about complementary feeding and provision of complementary foods on child growth in developing countries 显示文摘 | IMDAD A YAKOOB MY BHUTYA ZA | 2011 | BMC Public Health2011，11，3： | 1 |
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