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| 1 | The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells显示文摘The herbal medicine Tong Luo Jiu Nao(TLJN)contains geniposide(GP)and ginsenoside Rg1 at a molar ratio of 10:1.Rg1 is the major component of another herbal medicine,panax notoginseng saponin(PNS).TLJN has been shown to strengthen brain function in humans,and in animals it improves learning and memory.We have previously shown that TLJN reduces amyloidogenic processing in Alzheimer’s disease(AD)mouse models.Together this suggests TLJN may be a potential treatment for patients with dementia.Because chronic damage of the central nervous system by formaldehyde(FA)has been presented as a risk factor for age-associated cognitive dysfunction,in the present study we investigated the protective effect of both TLJN and GP in neuron-like cells exposed to FA.FA-exposed murine N2a neuroblastoma cells were incubated with TLJN,its main ingredient GP,as well as PNS,to measure cell viability and morphology,the rate of apoptosis and expression of genes encoding Akt,FOXO3,Bcl2 and p53.The CCK-8 assay,cytoskeletal staining and flow cytometry were used to test cell viability,morphology and apoptosis,respectively.Fluorescent quantitative real-time PCR(qRT-PCR)was used to monitor changes in gene expression,and HPLC to determine the rate of FA clearance.Treatment of N2a cells with 0.09 mmol L?1 FA for 24 h significantly reduced cell viability,changed cell morphology and promoted apoptosis.Both TLJN and GP conferred neuroprotection to FA-treated N2a cells,whereas PNS,which had to be used at lower concentrations because of its toxicity,did not.Our data demonstrate that TLJN can rescue neuronal damage caused by FA and that its main ingredient,GP,has a major role in this efficacy.This presents purified GP as a drug or lead compound for the treatment of AD. | CHEN JinYan SUN MengRu WANG XingHua LU Jing WEI Yan TAN Yan LIU Ying GTZ Jürgen HE RongQiao HUA Qian | 2014 | Science China(Life Sciences)2014，57，4： | 15 |
| 2 | Hoare logic-based genetic programming显示文摘Almost all existing genetic programming systems deal with fitness evaluation solely by testing. In this paper, by contrast, we present an original approach that combines genetic programming with Hoare logic with the aid of model checking and finite state automata, henceby proposing a brand new verification-focused formal genetic programming system that makes it possible to evolve reliable programs with mathematically-verified properties. | HE Pei KANG LiShan JOHNSON Colin G YING Shi | 2011 | Science China(Information Sciences)2011，54，3： | 5 |
| 3 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 4 | Dissipation of oxytetracycline in soils under different redox conditions显示文摘 | YANG J F YING G G ZHOU L J | 2009 | Environl Poll2009，157，10： | 1 |
| 5 | Purification and Characterization of Smooth Muscle Cell Caveolae显示文摘 | Chang Wenjin Ying Yunshu Karen G R | 1994 | Cell Biology1994，126，1： | 1 |
| 6 | Random seismic response analysis of adjacent buildings coupled with non-linear hysteretic dampers显示文摘 | Ni Y Q Ko J M Ying Z G | 2001 | Journal of Sound and Vibration2001，246，3： | 1 |
| 7 | Numerical study on the dynamics of a driven disordered vortex lattice 显示文摘 | Cao Y G Jiao Z K Ying H P | 2000 | Phys Rev B2000，62，： | 1 |
| 8 | Degradation of five selected endocrine- disrupting chemicals in seawater and marine sediment 显示文摘 | Ying G G Kookana R S | 2003 | Environmental Science and Technology2003，37，7： | 1 |
| 9 | Optimal nonlinear feedback control strategy for randomly excited struc- tural systems显示文摘 | Zhu W Q Ying Z G Soong T T | 2001 | Nonlinear Dynamics2001，24，4： | 1 |
| 10 | Effects of Yb3+on the corrosion resistance and deposition rate of electroless Ni-P deposits显示文摘 | Yan M Ying H G Ma T Y | 2008 | Applied Surface Science2008，255，5： | 1 |
| 11 | Reverse transcription loop-mediated isothermal amplification assay for detecting Tomato chlorosis virus 显示文摘 | Zhao L M Li G Gao Ying | 2015 | Journal of Virological Methods2015，213，： | 1 |
| 12 | Triclosan in wastewaters and biosolids from Australian wastewater treatment plants显示文摘 | YING G G KOOKANA R S | 2007 | Environ Int2007，33，2： | 1 |
| 13 | Occurrence and fate of hormone teroids in the environment显示文摘 | YING G G KOOKANA R S RU Y J | 2002 | Environment Intemational2002，28，6： | 1 |
| 14 | Preparation of Mo2C/HZSM-5 and its catalytic performance for the conversion of n-butane into aromatics显示文摘 | YUAN S DERANOUE-ABD HAMIDB S B LI Y YING P XIN Q DEROUANE E G LI C | 2002 | J Mol Catal A2002，184，12： | 1 |
| 15 | How Much does Labour Turnover Cost? - A Case Study of Australian Four- and Five-Star Hotels 显示文摘 | Michael C G Davidson Nils Timo Ying Wang | 2010 | International Journal of Contemporary Hospitality Management2010，22，4： | 1 |
| 16 | Increased blastocyst formation of cloned porcine embryos produced with donor cells pre-treated with Xenopus egg extract and/or digitonin显示文摘 | Ying Liu Olga ?strup Juan Li Gábor Vajta Lin Lin Peter M. Kragh Stig Purup Poul Hyttel Henrik Callesen | 2011 | Zygote2011，，1： | 1 |
| 17 | Regulation of body weight by leptin, with special reference to hypoxia-induced regulation显示文摘 | YING ZHONG Y DROMA Y RILl G | 2006 | Intern Med2006，45，16： | 1 |
| 18 | Degradation of five selected endocrine-disrupting chemicals in seawater and marine sediment 显示文摘 | Ying G G Kookana R S | 2003 | Environ Sci Technol2003，37，： | 1 |
| 19 | Occurrence and fate of hormone steroids in the environment 显示文摘 | Ying G G Kookana R S Rn Y J | 2002 | Environ Int2002，28，6： | 1 |
| 20 | Ubiquitin lig-ase Smurf1controls osteoblast activity and bone homeo-stasis by targeting MEKK2for degradation显示文摘 | Yamashita M Ying S X Zhang G M | 2005 | Cell2005，121，1： | 1 |
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