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| 1 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 2 | Histone methyltransferase G9a contributes to H3K27 methylation in vivo显示文摘 | Hui Wu Xiuzhen Chen Jun Xiong Yingfeng Li Hong Li Xiaojun Ding Sheng Liu She Chen Shaorong Gao Bing Zhu | 2011 | Cell Research2011，21，2： | 8 |
| 3 | A Hybrid Approach to Modeling and Control of Vehicle Height for Electronically Controlled Air Suspension显示文摘The control problems associated with vehicle height adjustment of electronically controlled air suspension(ECAS) still pose theoretical challenges for researchers, which manifest themselves in the publications on this subject over the last years. This paper deals with modeling and control of a vehicle height adjustment system for ECAS, which is an example of a hybrid dynamical system due to the coexistence and coupling of continuous variables and discrete events. A mixed logical dynamical(MLD) modeling approach is chosen for capturing enough details of the vehicle height adjustment process. The hybrid dynamic model is constructed on the basis of some assumptions and piecewise linear approximation for components nonlinearities. Then, the on-off statuses of solenoid valves and the piecewise approximation process are described by propositional logic, and the hybrid system is transformed into the set of linear mixed-integer equalities and inequalities, denoted as MLD model, automatically by HYSDEL. Using this model, a hybrid model predictive controller(HMPC) is tuned based on online mixed-integer quadratic optimization(MIQP). Two different scenarios are considered in the simulation, whose results verify the height adjustment effectiveness of the proposed approach. Explicit solutions of the controller are computed to control the vehicle height adjustment system in realtime using an offline multi-parametric programming technology(MPT), thus convert the controller into an equivalent explicit piecewise affine form. Finally, bench experiments for vehicle height lifting, holding and lowering procedures are conducted, which demonstrate that the HMPC can adjust the vehicle height by controlling the on-off statuses of solenoid valves directly. This research proposes a new modeling and control method for vehicle height adjustment of ECAS, which leads to a closed-loop system with favorable dynamical properties. | SUN Xiaoqiang CAI Yingfeng WANG Shaohua LIU Yanling CHEN Long | 2016 | Chinese Journal of Mechanical Engineering2016，29，1： | 7 |
| 4 | LiPO_(2)F_(2) electrolyte additive for high-performance Li-rich cathode material显示文摘Li-rich layered oxide cathodes have received considerable attention because of the high operating potential and specific capacity. However, the structural instability and parasitic reactions at high potential cause severe degradation of the electrochemical performance. In our studies, the cycling stability of Li_(1.14)Ni_(0.133)Co_(0.133)Mn_(0.544)O_(2) cathode is improved with LiPO_(2)F_(2) electrolyte additive. After 500 cycles, the capacity retention is increased from 53.6% to 85% at 3 C by LiPO_(2)F_(2) modification. This performance is mainly attributed to the enhanced interfacial stability of the Li-rich cathode. Based on systematic characterization, LiPO_(2)F_(2) additive was found to promote a stable interface film on the cathode surface during the cycling and mitigates the interfacial side reactions. This study provides new insights for improving high-potential Li-rich layered oxide batteries. | Bing Jiang Jingru Li Bi Luo Qizhang Yan Hao Li Lehao Liu Lihua Chu Yingfeng Li Qiaobao Zhang Meicheng Li | 2021 | Journal of Energy Chemistry2021，30，9： | 3 |
| 5 | Joint Communication and Processor Frequency Selection for Low-Energy Systems under Timing Constraints显示文摘This paper presents a method to reduce the energy consumption of multi-core systems characterized by processor cores and buses with discrete frequency levels under timing constraints.The proposed method takes the transformations of the original task graphs,which include dependent tasks located in different iterations,as inputs.The proposed method utilizes mapping selection as well as joint processor and communication frequency scaling to implement energy reduction.We conduct experiments on several random task graphs.Experimental results show that the proposed method can achieve substantial energy reduction compared with previous work under the same hard timing constraints. | WANG Yingfeng LIU Zhijing | 2010 | China Communications2010，7，4： | 3 |
| 6 | An e-quality control model for multistage machining processes of workpieces显示文摘To track and control the changes of process quality attributes in multistage machining processes(MMPs),an e-quality control(e-QC) model is proposed.The e-QC model is defined as a quality information service node with e-formalizing technology,whose input/output and intermediate process(that is IPO) are known to other nodes,and its implemention in MMPs is provided.In order to establish the e-QC model,a measuring network is constructed to acquire the original quality data,and the changes of process quality attributes are monitored and diagnosed by the integrated quality analysis tools attached to the e-QC,which can be tracked by information template network in real time.Furthermore,a hierarchical control method is adopted to coordinate e-QCs,in which the quality loss and adjusting cost are used to quantify the opportunities for e-QCs to improve process quality.At last,a prototype is developed to verify the proposed methods. | LIU DaoYu,JIANG PingYu & ZHANG YingFeng State Key Laboratory for Manufacturing Systems Engineering,Xi’an Jiaotong University,Xi’an 710049,China | 2008 | Science China(Technological Sciences)2008，51，12： | 3 |
| 7 | BIGpre: A Quality Assessment Package for Next-Generation Sequencing Data显示文摘The emergence of next-generation sequencing (NGS) technologies has significantly improved sequencing throughput and reduced costs. However, the short read length, duplicate reads and massive volume of data make the data processing much more difficult and complicated than the first-generation sequencing technology. Although there are some software packages developed to assess the data quality, those packages either are not easily available to users or require bioinformatics skills and computer resources. Moreover, almost all the quality assessment software currently available didn't taken into account the sequencing errors when dealing with the duplicate assessment in NGS data. Here, we present a new user-friendly quality assessment software package called BIGpre, which works for both Illumina and 454 platforms. BIGpre contains all the functions of other quality assessment software, such as the correlation between forward and reverse reads, read GC-content distribution, and base Ns quality. More importantly, BIGpre incorporates associated programs to detect and remove duplicate reads after taking sequencing errors into account and trimming low quality reads from raw data as well. BIGpre is primarily written in Perl and integrates graphical capability from the statistics package R. This package produces both tabular and graphical summaries of data quality for sequencing datasets from Illumina and 454 platforms. Processing hundreds of millions reads within minutes, this package provides immediate diagnostic information for user to manipulate sequencing data for downstream analyses. BIGpre is freely available at http://gffzz3d42f7e793a54046hnbpxxwqqokb66w5f.ffgz.tsg.suse.edu.cn/. | Tongwu Zhang Yingfeng Luo Kan Liu Linlin Pan Bing Zhang Jun Yu Songnlan Hu | 2011 | Genomics, Proteomics & Bioinformatics2011，9，6： | 3 |
| 8 | Surrounding Objects Detection and Tracking for Autonomous Driving Using LiDAR and Radar Fusion显示文摘Radar and LiDAR are two environmental sensors commonly used in autonomous vehicles,Lidars are accurate in determining objects’positions but significantly less accurate as Radars on measuring their velocities.However,Radars relative to Lidars are more accurate on measuring objects velocities but less accurate on determining their positions as they have a lower spatial resolution.In order to compensate for the low detection accuracy,incomplete target attributes and poor environmental adaptability of single sensors such as Radar and LiDAR,in this paper,an effective method for high-precision detection and tracking of surrounding targets of autonomous vehicles.By employing the Unscented Kalman Filter,Radar and LiDAR information is effectively fused to achieve high-precision detection of the position and speed information of targets around the autonomous vehicle.Finally,the real vehicle test under various driving environment scenarios is carried out.The experimental results show that the proposed sensor fusion method can effectively detect and track the vehicle peripheral targets with high accuracy.Compared with a single sensor,it has obvious advantages and can improve the intelligence level of autonomous cars. | Ze Liu Yingfeng Cai Hai Wang Long Chen | 2021 | Chinese Journal of Mechanical Engineering2021，34，5： | 2 |
| 9 | Numerical Simulation for Damping-Controlled Deployment of Z-Folded Inflatable Tube显示文摘The damping-controlled deployment technology of flexible Z-folded inflatable tube is one of the key technologies of space inflatable structures.Constraint failure between couple nodes is proposed to simulate the damping-controlled deployment.And the equation of constraint failure is established.Inflation process of Z-folded tube is simulated with control volume method.Compared with uncontrolled method,it is indicated that the new method can effectively solve the disordered deployment problem of the slender Z-folded inflatable tube.By analyzing the displacement of the apical of the folded tube with different constraint forces during deployment process,the concept of effective constraint force is proposed.In the effective region of constraint force,the folded tube deploys with little retraction and fluctuation.Otherwise,The flexible folded tube would deploy disorderly or even cannot deploy.The simulation method and numerical results have a theoretical and instructive significance to the research on the space inflatable structures. | Yu Li Zhan Yanan Shi Yingfeng Zhao Xiaoshun Liu Xin | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，4： | 2 |
| 10 | Safety and Efficacy of Biodegradable Polymer-Coated Sirolimus-Eluting Stents in “Real-World” Practice显示文摘 | Yaling Han Quanmin Jing Bo Xu Lixia Yang Huiliang Liu Xiaoming Shang Tieming Jiang Zhanquan Li Hua Zhang Hui Li Jian Qiu Yingfeng Liu Yi Li Xuezhi Chen Runlin Gao | 2009 | JACC: Cardiovascular Interventions2009，，4： | 2 |
| 11 | Multi-Branch Cable Harness Layout Design Based on Genetic Algorithm with Probabilistic Roadmap Method显示文摘Current studies on cable harness layouts have mainly focused on cable harness route planning.However,the topological structure of a cable harness is also extremely complex,and the branch structure of the cable harness can affect the route of the cable harness layout.The topological structure design of the cable harness is a key to such a layout.In this paper,a novel multi-branch cable harness layout design method is presented,which unites the probabilistic roadmap method(PRM)and the genetic algorithm.First,the engineering constraints of the cable harness layout are presented.An obstacle-based PRM used to construct non-interference and near to the surface roadmap is then described.In addition,a new genetic algorithm is proposed,and the algorithm structure of which is redesigned.In addition,the operation probability formula related to fitness is proposed to promote the efficiency of the branch structure design of the cable harness.A prototype system of a cable harness layout design was developed based on the method described in this study,and the method is applied to two scenarios to verify that a quality cable harness layout can be efficiently obtained using the proposed method.In summary,the cable harness layout design method described in this study can be used to quickly design a reasonable topological structure of a cable harness and to search for the corresponding routes of such a harness. | Yingfeng Zhao Jianhua Liu Jiangtao Ma Linlin Wu | 2021 | Chinese Journal of Mechanical Engineering2021，34，2： | 2 |
| 12 | Study on cure reaction of the blends of bismaleimide and dicyanate ester 显示文摘 | Xiaoyun Liu Yingfeng Yu Shanjun Li | 2006 | Polymer2006，47，11： | 1 |
| 13 | Viscoelastic phase separation in polyethersulfone modified bismaleimide resin 显示文摘 | Liu Xiaoyun Yu Yingfeng Li Shanjun | 2006 | European Polymer Journal2006，42，： | 1 |
| 14 | Viscoelastic phase separation in polyethersulfone modified bismaleimeide resin 显示文摘 | Liu Xiaoyun Yu Yingfeng Li Shanjun | 2005 | European Polymer Journal2005，，10： | 1 |
| 15 | Viscoelastic phase separa-tion in polyethersulfone modified bismaleimide resin显示文摘 | Xiaoyun Liu Yingfeng Yu Shanjun Li | 2005 | European Polymer Journal2005，42，4： | 1 |
| 16 | Viscoelastic Phase Separation in Polyethersulfone Modified Bismaleimide Resin 显示文摘 | Liu Xiaoyun Yu Yingfeng Li Shanjun | 2006 | European Polymer Journal2006，42，4： | 1 |
| 17 | Study on cure reaction of the blends of bismaleimide and dicyanate ester显示文摘 | Xiaoyun Liu Yingfeng Yu Shanjun Li | 2006 | Polymer2006，47，： | 1 |
| 18 | Study on cure reaction of the blends of bismaleimide and dicyanate ester 显示文摘 | Liu Xiaoyun Yu Yingfeng Li Shanjun | 2006 | Polymer2006，47，11： | 1 |
| 19 | Diatom-inspired multiscale mineralization of patterned protein-polysaccharide complex structures显示文摘Marine diatoms construct their hierarchically ordered,three-dimensional(3D)external structures called frustules through precise biomineralization processes.Recapitulating the remarkable architectures and functions of diatom frustules in artificial materials is a major challenge that has important technological implications for hierarchically ordered composites.Here,we report the construction of highly ordered,mineralized composites based on fabrication of complex self-supporting porous structures—made of genetically engineered amyloid fusion proteins and the natural polysaccharide chitin—and performing in situ multiscale protein-mediated mineralization with diverse inorganic materials,including SiO_(2),TiO_(2)and Ga_(2)O_(3).Subsequently,using sugar cubes as templates,we demonstrate that 3D fabricated porous structures can become colonized by engineered bacteria and can be functionalized with highly photoreactive minerals,thereby enabling co-localization of the photocatalytic units with a bacteria-based hydrogenase reaction for a successful semi-solid artificial photosynthesis system for hydrogen evolution.Our study thus highlights the power of coupling genetically engineered proteins and polysaccharides with biofabrication techniques to generate hierarchically organized mineralized porous structures inspired by nature. | Ke Li Yingfeng Li Xinyu Wang Mengkui Cui Bolin An Jiahua Pu Jintao Liu Boyang Zhang Guijun Ma Chao Zhong | 2021 | National Science Review2021，8，8： | 1 |
| 20 | Study on cure reaction of the blends of bismaleimide and dicyanate ester 显示文摘 | Liu Xiaoyun Yu Yingfeng Li Shanjun | 2006 | Polymer2006，47，11： | 1 |
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