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| 1 | 智慧制造系统的基础理论与技术体系显示文摘智慧制造作为一种新兴制造模式,其研究和实践需要理论与技术体系的支持.从系统科学的角度出发,探讨了智慧制造系统组成、子系统的相互作用以及其特征等基础理论问题,并提出了由总体与基础技术、面向人际网的社会化制造技术、面向知识网的智能化制造技术、面向务联网的服务化制造技术以及面向物联网的制造物联技术组成的智慧制造系统技术体系. | 姚锡凡 张剑铭 LIN Yingzi | 2016 | 系统工程理论与实践2016，36，10： | 27 |
| 2 | The challenge of training for family medicine across different contexts:Insights from providing training in China显示文摘Physicians with expertise in providing training for family medicine,at both undergraduate level and postgraduate level,are frequently invited to run training workshops in countries with developing systems of family medicine but this approach is often a challenge for the incoming external trainers.There are general challenges in working across different contexts,especially cul-tural factors,the different approaches to training,including the aims,methods,and assessment,and additional organizational factors,influenced by the wider sociopolitical environment of the host country.Practical responses to these challenges are discussed,with relevance to both external trainers and those responsible for requesting training.This commentary contains insights from the experiences of the authors in providing training for family medicine in China. | John Sandars Yingzi Huang Trevor Gibbs | 2016 | Family Medicine and Community Health2016，4，2： | 14 |
| 3 | Gut microbiota metabolite regulation of host defenses at mucosal surfaces:implication in precision medicine显示文摘The gut microbiota has a well-established role in the regulation of host homeostasis.Multiple factors control the composition and function of the microbiota.The westernization of diet,a shift away from nutrient-dense foods toward diets high in saturated fats,has been implicated in the rise of chronic inflammatory diseases such as inflammatory bowel disease(IBD).Diet is critical in the development and maintenance of a healthy microbiome,where dietary fiber(found in the highest amounts in fruits,vegetables,and legumes)is metabolized by the microbiome.In turn,the bacterial metabolites of dietary fiber,short chain fatty acids(SCFAs),regulate gut homeostasis.SCFAs engage G-protein coupled receptors(GPRs)and act as histone deacetylase inhibitors(HDACi)to module epithelial and immune cell functions in the intestines,where they generally promote an anti-inflammatory state.This review highlights the functions of SCFAs and their roles in the pathogenesis of IBD to provide insights into their potential therapeutic application for the treatment of IBD for the purposes of precision medicine. | Anthony J.Bilotta Yingzi Cong | 2019 | Precision Clinical Medicine2019，2，2： | 13 |
| 4 | Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases显示文摘The gut microbiota has a critical role in the maintenance of immune homeostasis.Alterations in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in many immune-related inflammatory disorders.These metabolites can be produced by gut microbiota from dietaiy components or by the host and can be modified by gut bacteria or synthesized de novo by gut bacteria.Gut microbiota-derived metabolites influence a plethora of immune cell responses,including T cells,B cells,dendritic cells,and macrophages.Som e of these metabolites are involved in the pathogenesis of immune-related inflammatory diseases,such as inflammatory bowel diseases,diabetes,rheumatoid arthritis,and systemic lupus erythematosus.Here,we review the role of microbiota-derived metabolites in regulating the functions of different immune cells and the pathogenesis of chronic immune-related inflammatory diseases. | Wenjing Yang Yingzi Cong | 2021 | Cellular & Molecular Immunology2021，18，4： | 10 |
| 5 | Deformation Behavior and Microstructure Evolution of Wrought Magnesium Alloys显示文摘There are many researches on the deformation behavior of wrought magnesium alloys, such as AZ31, AZ80, AZ91, and ZK60 magnesium alloys at different temperatures and strain rates, but few of them focuses on the deformation behavior of AZ41M and ZK60M alloys, especially under the twin-roll casting (TRC) state. Meanwhile, the existing researches only focus on the grain refinement law of the magnesium alloys under deformation conditions, the deformation mechanism has not been revealed yet. The hot compression behavior of AZ41M and ZK60M magnesium alloys under the temperature and strain rate ranges of 250-400 ℃ and 0.001-1 s-1 are studied by thermal simulation methods using Gleeble 1500 machine and virtual simulation using finite element analysis software. Simulation results show that sine hyperbolic law is the most suitable flow stress model for wider deformation conditions. The most reasonable selected deformation conditions of ZK60M alloy is 350 oC/0.1 s-1 for TRC and 350 oC/1 s-1 for conventional casting (CC), while AZ41M alloy is 300 oC/0.01 s-1 for TRC and 350 oC/0.1 s-1 for CC. Deformation behavior and dynamic recrystallization (DRX) mechanism of them are analyzed at the same deformation conditions. The microstructures of AZ41M and ZK60M alloys are observed at different deformed conditions by optical microscopy (OM) and electron back scatter diffraction (EBSD) and it reveals the flow behavior and deformation mechanism of them. Working harden and work soften contribute to the activation of basal, non-basal slip systems which promote DRX. The proposed research reveals the deformation behavior and mechanism of the AZ41M and ZK 60M magnesium alloys and concludes their optimized deformation parameters and processes and provides a theory basis for their manufacturing and application. | WANG Shouren SONG Linghui KANG Sukbong CHO Jaehyung WANG Yingzi | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 9 |
| 6 | Gα_s signaling controls intramembranous ossification during cranial bone development by regulating both Hedgehog and Wnt/β-catenin signaling显示文摘How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal genetic diseases that exhibit craniofacial bone defects. The GNAS gene encodes Gαs that transduces GPCR signaling. GNAS activation or loss-of-function mutations in humans cause fibrous dysplasia(FD) or progressive osseous heteroplasia(POH) that shows craniofacial hyperostosis or craniosynostosis, respectively. We find here that, while Hh ligand-dependent Hh signaling is essential for endochondral ossification, it is dispensable for intramembranous ossification, where Gαsregulates Hh signaling in a ligand-independent manner. We further show that Gαscontrols intramembranous ossification by regulating both Hh and Wnt/β-catenin signaling. In addition, Gαsactivation in the developing cranial bone leads to reduced ossification but increased cartilage presence due to reduced cartilage dissolution, not cell fate switch. Small molecule inhibitors of Hh and Wnt signaling can effectively ameliorate cranial bone phenotypes in mice caused by loss or gain of Gnas function mutations, respectively. Our work shows that studies of genetic diseases provide invaluable insights in both pathological bone defects and normal bone development, understanding both leads to better diagnosis and therapeutic treatment of bone diseases. | Ruoshi Xu Sanjoy Kumar Khan Taifeng Zhou Bo Gao Yaxing Zhou Xuedong Zhou Yingzi Yang | 2018 | Bone Research2018，6，4： | 7 |
| 7 | Unsteady Flow Characteristic of Low-Specific-Speed Centrifugal Pump under Different Flow-Rate Conditions显示文摘To investigate the unsteady flow characteristics in centrifugal pump, the flow field in a low-specific-speed centrifugal pump with complex impeller is numerically simulated under different conditions. The RNG κ-ε turbulence model and sliding mesh are adopted during the process of computation. The results show that the interaction between impeller and volute results in the unstable flow of the fluid, which causes the uneven distribution of pressure fluctuations around the circumference of volute. Besides the main frequency and its multiple frequency of pressure fluctuations in the centrifugal pump, the frequency caused by the long blades of complex impeller also plays a dominant role in the low-frequency areas. Furthermore, there exists biggish fluctuation phenomenon near the tongue. The composition of static pressure fluctuations frequency on the volute wall and blade outlet is similar except that the fluctuation amplitude near the volute wall reduces. In general, the different flow rates mainly have influence on the amplitude of fluctuation frequency in the pump, while have little effect on the frequency composition. | CUI Baoling CHEN Desheng XU Wenjing JIN Yingzi ZHU Zuchao | 2015 | Journal of Thermal Science2015，24，1： | 7 |
| 8 | IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis显示文摘Viral hepatitis is still a public health problem affecting several million people around the world.Neutrophils are polymorphonuclear cells that have a critical role in antibacterial infection.However,the role of neutrophils in viral infection is not fully understood.By using a mouse model of lymphocytic choriomeningitis virus infection-induced viral hepatitis,we observed increased neutrophil recruitment in the liver accompanied by enhanced CD8+T-cell responses.Liver neutrophils expressed high levels of immunomodulatory cytokines,such as C-X-C chemokine ligand 2,arginase-1,inducible nitric oxide synthase and interleukin(IL)-10,demonstrating immunosuppressive properties.Depletion of neutrophils in vivo by a neutralizing antibody resulted in the exacerbation of liver injury and the promotion of T-cell responses at the immune contraction stage.IL-33 significantly induced neutrophil recruitment in the liver and attenuated liver injury by limiting effector T-cell accumulation.Mechanistically,we found that IL-33 promoted the expression of arginase-1 in neutrophils through the type 2 innate lymphoid cell(ILC2)-derived IL-13.Additionally,IL-13 increased the inhibitory effect of neutrophils on CD8+T-cell proliferation in vitro,partially through arginase-1.Finally,we found that IL-13 induced arginase-1 expression,depending on signal transducer and activator of transcription factor 6(STAT6)signaling.Therefore,IL-33 induced immunosuppressive neutrophils via an ILC2/IL-13/STAT6 axis.Collectively,our findings shed new light on the mechanisms associated with IL-33-triggered neutrophils in the liver and suggest potential targets for therapeutic investigation in viral hepatitis. | Yuejin Liang Panpan Yi Denley Ming Kee Yuan Zuliang Jie Zakari Kwota Lynn Soong Yingzi Cong Jiaren Sun | 2019 | Cellular & Molecular Immunology2019，16，2： | 7 |
| 9 | 走向新一代可持续制造——包容性制造显示文摘全球人口及其对产品需求的日益增长导致环境问题与日俱增,伴随着工业4.0而来的新兴技术和新型工业模式也对社会生产、分配、交换、消费产生了前所未有的巨大影响,因此如何在实现可持续制造的同时,满足社会包容性发展理念就成为新工业革命时代亟需解决的问题。首先从产品、生产过程和系统层面分析了可持续制造面临的机遇和挑战,然后阐述了包容性制造的诞生背景及其在新一轮科技与产业革命下的发展动态,接着论述了从可持续制造走向包容性制造的技术路线,并在集成长尾制造与可持续制造(再制造)的基础上融合社会信息物理系统、大数据和区块链技术,构建了以人为本的包容性制造体系架构——社会经济技术生产系统,最后对比分析了包容性制造和可持续制造的异同,并从螺旋动力学视角阐述从面向环境的可持续制造走向以人为本的包容性制造的必然性。 | 姚锡凡 景轩 周佳军 LIN Yingzi | 2019 | 计算机集成制造系统2019，25，10： | 7 |
| 10 | A study on solid density primary standard显示文摘The accuracy of solid density primary standard is decided mainly by the accuracy of the diameter measurement of silicon sphere. With traditional five-interferogram algorithm to unwrap phase for di- ameter measurement, the phase steps should be equal to π/2 exactly, but this is almost impossible to achieve in nanometer positioning technique. In order to overcome this defect, we have derived an im- proved five-interferogram algorithm, which not only keeps the high accuracy of traditional five-inter- ferogram algorithm, but also does not require absolute equal step to unwrap phase. Instead, the im- proved five-interferogram algorithm only needs measuring phase shifting. Based on the improved al- gorithm, we have developed a novel interferometer with special etalon, and the cavity length of this etalon can be changed by pressure from vertical direction to realize phase shifting. The accuracy of this interferometer is better than 3 nm and can be improved in future research. | LUO ZhiYong YANG LiFeng GU YingZi GUO LiGong DING JinGan | 2007 | Chinese Science Bulletin2007，52，21： | 6 |
| 11 | Study on Airflow Characteristics in the Semi-Closed Irregular Narrow Flow channel显示文摘The air-jet loom is widely used in the textile industry. The interaction mechanism of airflow and yarn is not clear in such a narrow flow channel, the gas consumption is relatively large, the yarn motion is unstable and the weft insertion is often interrupted during the operation. In order to study the characteristics of the semi-closed flow field in profiled dents, the momentum conservation equation is modified and the model parameters and boundary conditions are set. Compared with the different r, the ratio of profiled dent's thickness and gap, the results show that the smaller the r is, the smaller the velocity fluctuations of the airflow is. When the angle of profiled dents ? is close to zero, the diffusion of the airflow will be less. The experiment is also conducted to verify the result of the simulation with a high-speed camera and pressure sensor in profiled dents. The airflow characteristics in the semi-closed irregular narrow flow channel in the paper would provide the theoretical basis for optimizing the weft insertion process of the air-jet loom. | JIN Yuzhen HU Xiaodong ZHU Linhang HU Xudong JIN Yingzi | 2016 | Journal of Thermal Science2016，25，2： | 6 |
| 12 | Effects of high-frequency oscillatory ventilation and conventional mechanical ventilation on oxygen metabolism and tissue perfusion in sheep models of acute respiratory distress syndrome显示文摘 | Liu Songqiao Huang Yingzi Wang Maohua Chen Qiuhua Liu Ling Xie Jianfeng Tan Li Guo Fengmei Yang Congshan Pan Chun Yang Yi Qiu Haibo | 2014 | Chinese Medical Journal2014，，18： | 6 |
| 13 | Numerical Analysis of Chevron Nozzle Effects on Performance of the Supersonic Ejector-Diffuser System显示文摘The supersonic nozzle is the most important device of an ejector-diffuser system.The best operation condition and optimal structure of supersonic nozzle are hardly known due to the complicated turbulent mixing,compressibility effects and even flow unsteadiness which are generated around the nozzle extent.In the present study,the primary stream nozzle was redesigned using convergent nozzle to activate the shear actions between the primary and secondary streams,by means of longitudinal vortices generated between the Chevron lobes.Exactly same geometrical model of ejector-diffuser system was created to validate the results of experimental data.The operation characteristics of the ejector system were compared between Chevron nozzle and conventional convergent nozzle for the primary stream.A CFD method has been applied to simulate the supersonic flows and shock waves inside the ejector.It is observed that the flow structure and shock system were changed and primary numerical analysis results show that the Chevron nozzle achieve a positive effect on the supersonic ejector-diffuser system performance.The ejector with Chevron nozzle can entrain more secondary stream with less primary stream mass flow rate. | Fanshi Kong Yingzi Jin Toshiaki Setoguchi Heuy Dong Kim | 2013 | Journal of Thermal Science2013，22，5： | 5 |
| 14 | Dynamics of Above-and Below-ground Biomass and C,N,P Accumulation in the Alpine Steppe of Northern Tibet显示文摘The temporal dynamics of the biomass,as well as the carbon (C),nitrogen (N),phosphorus (P) concentrations and accumulation contents,in above-and below-ground vegetation components were determined in the alpine steppe vegetation of Northern Tibet during the growing season of 2010.The highest levels of total biomass (311.68 g m-2),total C (115.95 g m-2),total N (2.60 g m-2),and total P (0.90 g m-2) accumulation contents were obtained in August in 2010.Further,biomass and nutrient stocks in the below-ground components were higher than those of the above-ground components.The dominant species viz.,Stipa purpurea and Carex moorcrofti had lower biomass and C,N,P accumulations than the companion species which including Oxytropis.spp.,Artemisia capillaris Thunb.,Aster tataricus L.,and so on. | LU Xuyang YAN Yan FAN Jihui CAO Yingzi WANG Xiaodan | 2011 | Journal of Mountain Science2011，8，6： | 5 |
| 15 | Experimental Study on a Centrifugal Pump with an Open Impeller during Startup Period显示文摘Transient performance of fluid machinery during transient operating periods,such as startup and stopping,has been drawn more attentions recently due to the growing engineering needs.In this paper,the transient behavior of a prototype centrifugal pump with an open impeller during rapid startup period is studied experimentally.The variations of the rotational speed,flow rate,head,and shaft power during rapid startup period are recorded in experiments at different discharge valve openings.In addition,the non-dimensional flow rate and head are also used to analyze the transient behavior.The research result shows that the rise characteristic of the rotational speed is not basically changed by working points,while mainly depends on the startup characteristics of the driving motor.Compared with the rapid rise of the rotational speed,the flow rate rises slowly in the initial stage of startup.Moreover,the flow rate lags behind the rotational speed to rise to final stable value,and the delay becomes more severe with the increase of the discharge valve opening.The shaft power impact phenomenon generally exists in the process of startup.The non-dimensional analysis shows that the non-dimensional head is very high at the very beginning of startup,and quickly falls to the minimum,then gradually rises to final stable value,while the non-dimensional flow rate always shows the rise tendency during whole startup period.In conclusion,it is found from the non-dimensional results that the quasi-steady analysis is unable to accurately assess the transient flow during startup period. | Yuliang Zhang Zuchao Zhu Yingzi Jin Baoling Cui Yi Li Huashu Dou | 2013 | Journal of Thermal Science2013，22，1： | 5 |
| 16 | Fluorescence spectroscopic studies of the effect of granular activated carbon adsorption on structural properties of dissolved organic matter fractions显示文摘这个工作在第二等的自河在溶解有机物( DOM )的荧光特征上调查了小粒的激活的碳吸附( GACA )的效果,借助于刺激排放矩阵( EEM )系列,荧光地区性的集成(星期五)方法,同步系列,在刺激在 500 nm 在波长 450 nm 定义为荧光排放紧张的比率到那的荧光索引(<潜水艇class=“ a-plus-plus ”>前)=通信的 370 nm ,和波长 t 在从北方废水处理工厂的第二等的自河的 DOM (沈阳,中国) 是用进 5 部分的 XAD 树脂的 fractionated:恐水病的酸(HPO -- 一) ,恐水病中立(HPO-N ) , transphilic 酸(TPI -- 一) , transphilic 中立(TPI-N ) 并且吸水的部分(HPI ) 。结果显示出那荧光灯在 HPO-N 和 TPI-N 的材料被 GACA 不太乐意地在另外的部分比那些移开。相对内容荧光灯在 HPO 的材料 -- 一, TPI -- 而那作为 GACA 的后果在 HPO-N 和 TPI-N 增加了, A 和 HPI 减少了。在所有 DOM 部分的多不的 aromatics 被 GACA 优先地吸收,与表示为文档的体积 DOM 比较。在另一方面,芳香的氨基酸的吸附和由 GACA 在同步系列展出荧光山峰的腐殖的像酸的 fluorophores 似乎依赖于 DOM 部分的酸 / 中立性质。所有五部分减少了由于 GACA 的荧光索引。GACA 导致了一减少 < 潜水艇 class= “ a-plus-plus ” > 为 HPO 的 0.5 价值 -- 一,增加 < 潜水艇 class= “ a-plus-plus ” > 为 HPO-N 的 0.5 价值, TPI -- A 和 HPI,并且一一致 < 潜水艇 class= “ a-plus-plus ” > 为 TPI-N 的 0.5 价值。 | Shuang XUE Qingliang ZHAO Liangliang WEI Xiujuan HUI Xiping MA Yingzi LIN | 2012 | Frontiers of Environmental Science & Engineering2012，6，6： | 5 |
| 17 | Chromatographic fingerprinting and quantitative analysis for the quality evaluation of Xinkeshu tablet显示文摘A simple, sensitive and accurate method based on high performance liquid chromatography (HPLC) with diode array detector (DAD) was developed and validated for systematic quality evaluation of one type of traditional Chinese medicine preparations named Xinkeshu (XKS) tablet. In this study, the chromatographic fingerprints of XKS tablet were developed first, 23 peaks were selected as the common peaks to evaluate the similarities among different batches of XKS samples, which were manufactured in a long time span of three years. Additionally, simultaneous quantification of six markers in XKS tablet, including Danshensu, Protocatechuic aldehyde, Puerarin, Daidzin, Salvianolic acid B and Daidzein, was performed. The validation results showed that the developed method was specific, accurate, precise and robust. The preliminary explanation on why a close similarity between fingerprints did not exactly mean similar contents of chemical components in samples was given. The contribution of each chromatographic peak to similarity was also evaluated. The developed method offers an efficient, reliable and practical approach for systematic quality evaluation of XKS tablet. | Pei Wang Lian Li Hailong Yang Shijuan Cheng Yingzi Zeng Lei Nie Hengchang Zang | 2012 | Journal of Pharmaceutical Analysis2012，2，6： | 5 |
| 18 | Effects of rotor structure on performance of small size axial flow fans显示文摘Small size axial flow fans are used as a cooling component for computers,electronic equipment and other electronic components.With the increasing power of electrical equipment,the demand for lower noise and higher ventilation of cooling fan is also increasing.Traditional methods of improving ventilation by raising the fan's rotation speed causes a decrease in efficiency and an increase in noise.In this paper,different structures of fans were simulated,and as a result,the counter-rotating fan can achieve higher pressure,efficiency and facilitate ventilation in a smaller space.Furthermore,some other conclusions are as follows:(1) Higher pressure rise can be obtained by a counter-rotating fan than by the two-stage rotor fan in the same axial length.Meanwhile,the counter-rotating fan has a broader work scope.(2) The main noise type of the counter-rotating fan is rotating noise;the small peak pulse caused by vortex noise mainly due to the eddy current produced by small eddies.(3) When the distance of counter-rotating fans is smaller than 2 times the chord,the greater distance the greater total pressure of the circum-averages and along the axial direction,the total pressure begin to decline until the distance is three times the chord,so there is an optimal distance between rotors.The simulation results are of important significance to the quantitative analysis and optimization design of the counter-rotating fan. | Pin Liu Yingzi Jin Yanping Wang | 2011 | Journal of Thermal Science2011，20，3： | 5 |
| 19 | Baicalin inhibits colistin sulfate-induced apoptosis of PC12 cells显示文摘Baicalin,a type of flavonoid extracted from the dried root of Scutellaria baicalensis georgi,has been shown to effectively inhibit cell apoptosis.Therefore,we assumed that baicalin would suppress colistin sulfate-induced neuronal apoptosis.PC12 cells exposed to colistin sulfate(62.5–500μg/mL)for 24 hours resulted in PC12 cell apoptosis.In addition,caspase-3 activity,lactate dehydrogenase level and free radical content increased in a dose-dependent manner.Subsequently,PC12 cells were pretreated with baicalin(25,50 and 100μg/mL),and exposed to 125μg/mL colistin sulfate.Cell morphology markedly changed,and cell viability increased.Moreover,caspase-3 activity,lactate dehydrogenase level and free radical content decreased.Results indicated that baicalin inhibited colistin sulfate-induced PC12 cell apoptosis by suppressing free radical injury,and reducing caspase-3 activity and lactate dehydrogenase activity. | Hong Jiang Pengfei Lv Jichang Li Hongjun Wang Tiezhong Zhou Yingzi Liu Wei Lin | 2013 | Neural Regeneration Research2013，8，28： | 4 |
| 20 | Numerical and Experimental Study on Aerodynamic Performance of Small Axial Flow Fan with Splitter Blades显示文摘To improve the aerodynamic performance of small axial flow fan, in this paper the design of a small axial flow fan with splitter blades is studied. The RNG k-ε turbulence model and SIMPLE algorithm were applied to the steady simulation calculation of the flow field, and its result was used as the initial field of the large eddy simulation to calculate the unsteady pressure field. The FW-H noise model was adopted to predict aerodynamic noise in the six monitoring points. Fast Fourier transform algorithm was applied to process the pressure signal. Experiment of noise testing was done to further investigate the aerodynamic noise of fans. And then the results obtained from the numerical simulation and experiment were described and analyzed. The results show that the static characteristics of small axial fan with splitter blades are similar with the prototype fan, and the static characteristics are improved within a certain range of flux. The power spectral density at the six monitoring points of small axial flow fan with splitter blades have decreased to some extent. The experimental results show sound pressure level of new fan has reduced in most frequency bands by comparing with prototype fan. The research results will provide a proof for parameter optimization and noise prediction of small axial flow fans with high performance. | Zhu Lifu Jin Yingzi Li Yi Jin Yuzhen Wang Yanping Zhang Li | 2013 | Journal of Thermal Science2013，22，4： | 4 |
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