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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 3 | 1型糖尿病患者的血糖控制,心脏自身免疫和心血管病的长期风险显示文摘血糖控制不佳与1型糖尿病(type 1diabetes mellitus,T1DM)患者的心血管病风险增加有关;然而,对T1DM的特异性机制知之甚少。在T1DM中,心肌损伤可诱发持续的心脏自身免疫。慢性高血糖症引起心肌损伤,高血糖诱导的心脏自身免疫可能导致长期心血管病并发症的可能性。 | Sousa GR Pober D Galderisi A Lv H Yu L Pereira AC Doria A Kosiborod M Lipes MA 刘莉 叶鹏 | 2019 | 中华高血压杂志2019，27，1： | 8 |
| 4 | Tissue differential expression of lycopene β-cyclase gene in papaya显示文摘Carotene pigments in flowers and fruits are distinct features related to fitness advantages such as attracting insects forpollination and birds for seed dispersal.In papaya,the flesh color of the fruit is considered a quality trait that correlateswith nutritional value and is linked to shelf-life of the fruit.To elucidate the carotenoid biosynthesis pathway in papaya,we took a candidate gene approach to clone the lycopene β-cyclase gene,LCY-B.A papaya LCY-B ortholog,cpLCY-B,was successfully identified from both cDNA and bacterial artificial chromosome(BAC)libraries and complete genomicsequence was obtained from the positive BAC including the promoter region.This cpLCY-B shared 80% amino acididentity with citrus LCY-B.However,full genomic sequences from both yellow- and red-fleshed papaya were identical.Quantitative real-time PCR(qPCR)revealed similar levels of expression at six different maturing stages of fruits forboth yellow-and red-fleshed genotypes.Further expression analyses of cpLCY-B showed that its expression levels wereseven- and three-fold higher in leaves and,respectively,flowers than in fruits,suggesting that cpLCY-B is down-regulatedduring the fruit ripening process. | Rachel L Skelton Qingyi Yu Rajeswari Srinivasan Richard Manshardt Paul H Moore Ray Ming | 2006 | Cell Research2006，16，8： | 8 |
| 5 | 用矿化牛骨块onlay植骨水平重建前颌骨严重萎缩性牙槽嵴:一项为期6年的前瞻性研究显示文摘目的:评估应用矿化牛骨块重建前颌骨的牙槽嵴水平缺损的onlay(上置式)植骨的有效性和长期结果。材料与方法:14例需要修复无牙前颌骨的患者纳入本研究,他们接受onlay植骨。劈开从下颌支的外侧获取的皮质骨块,以获得约1mm厚的骨板。将皮质骨板和块状移植物压缩并固定到受区。6个月后,记录增加的宽度,植入种植体。 | Qiu L Yu H 赵泽亮 | 2018 | 中国口腔颌面外科杂志2018，16，4： | 6 |
| 6 | Anisotropic damage model under continuum slip crystal plasticity theory for single crystals显示文摘 | Feng L Zhang K S Zhang G Yu H D | 2002 | International Journal of Solids and Structures2002，39，： | 2 |
| 7 | Fine mapping of a C-terminal linear epitope highly conserved among the major envelope gly coprotein E2 (gpS1 to gp54) of different pestiviruses显示文摘 | Yu M Wang L F Shiell B J Morrissy C J Westbury H A | 1996 | Virology1996，222，： | 1 |
| 8 | In-situ weld-alloying/laser beam welding of/6061A1 MMC 显示文摘 | Wang H M Chen Y L and Yu L G | 2000 | Materials Science and Engineering2000，293，1： | 1 |
| 9 | Development of nanophase CeO2- Pt/C cathode catalyst for direct methanol fuel cell 显示文摘 | YU H B KIM J Y LEE H l | 2005 | J Power Sources2005，140，： | 1 |
| 10 | A novel demodulation scheme for fiber Bragg grating sensor system显示文摘 | YU Y L ZHAO H X | 2005 | IEEE Photonics Technology Letters2005，17，1： | 1 |
| 11 | Effects of thawing temperature on the physicochemical properties of pre-dgor frozen chicken breast and leg muscles显示文摘 | YU L H LEE E S JEONG J Y | 2005 | Meat Science2005，71，2： | 1 |
| 12 | Standard CMOS implementation of a novel, fully differential optoelectronic integrated receiver 显示文摘 | YU C L MAO L H XIAO X D | 2009 | J of Optoelectronics Laser2009，20，4： | 1 |
| 13 | Small molecular glasses based on muhiposition encapsulated phenyl benzimidazole iridium(III) complexes: Toward efficient solution-processable host-free electrophosphorescent diodes显示文摘 | Xu H Yu D H Liu L L | 2010 | Journal of Physical Chemistry B2010，114，1： | 1 |
| 14 | Synthesis and characterization of substitutional and interstitial nitrogen-doped titanium dioxides with visible light photocatalytic activity显示文摘 | Peng F Cai L Yu H | 2008 | J Solid State Chem2008，181，4： | 1 |
| 15 | An existence theorem for equilibrium points for multi-leaders-follower games显示文摘 | Yu J Wang H L | 2008 | Nonlinear Analysis TMA2008，69，56： | 1 |
| 16 | Liquid chromatography-tandem mass/mass spec- trometry method for the quantification of rabeprazole in human plasma and application to a pharmacokinetic study显示文摘 | Yu L Deng H Xiang B | 2010 | Armeimittelforschung2010，60，5： | 1 |
| 17 | Rare-earth oxide coating for sub-micro particulates reinforced aluminum matrix composites 显示文摘 | YU Z Q WU G H SUN D L | 2003 | Mater Sci Eng2003，357，： | 1 |
| 18 | Expression of cyclooxygenase-2 (Cox-2) in human esophageal cancer and in vitro inhibition by a specific Cox-2 inhibitor, NS-398 显示文摘 | Yu H P Shi L Y Lu W H | 2004 | J Gastroenterol Hepatol2004，19，6： | 1 |
| 19 | IgC, anti-melanocyte antibodies purified from patients with active vitiligo induce HLA-DR and intercellular adhesion molecule-1 expression and an increase in interleukin-8 release by melanocytes 显示文摘 | Li Y L Yu C L Yu H S | 2000 | J Invest Dermatol2000，115，6： | 1 |
| 20 | Dynamics analysis of a two-body gravitationally oriented satellite显示文摘 | Fletcher H J Rongved L Yu E Y | 1963 | Bell System Tech J1963，42，5： | 1 |
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