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| 1 | Summer atmospheric boundary layer structure in the hinterland of Taklimakan Desert, China显示文摘Understanding the characteristics of the structure of desert atmospheric boundary layer and its land surface process is of great importance to the simulations of regional weather and climate.To investigate the atmospheric boundary layer structure and its forming mechanism of Taklimakan Desert,and to improve the accuracy and precision of regional weather and climate simulations,we carried out a GPS radiosonde observation experiment in the hinterland of Taklimakan Desert from 25 June to 3 July,2015.Utilizing the densely observed sounding data,we analyzed the vertical structures of daytime convective boundary layer and nighttime stable boundary layer in summer over this region,and also discussed the impacts of sand-dust and precipitation events on the desert atmospheric boundary layer structure.In summer,the convective boundary layer in the hinterland of Taklimakan Desert developed profoundly and its maximum height could achieve 4,000 m;the stable boundary layer at nighttime was about 400–800-m thick and the residual mixing layer above it could achieve a thickness over 3,000 m.Sand-dust weather would damage the structures of nighttime stable boundary layer and daytime convective boundary layer,and the dust particle swarm can weak the solar radiation absorbed by the ground surface and further restrain the strong development of convective boundary layer in the daytime.Severe convective precipitation process can change the heat from the ground surface to the atmosphere in a very short time,and similarly can damage the structure of desert atmospheric boundary layer remarkably.Moreover,the height of atmospheric boundary layer was very low when raining.Our study verified the phenomenon that the atmospheric boundary layer with supernormal thickness exists over Taklimakan Desert in summer,which could provide a reference and scientific bases for the regional numerical models to better represent the desert atmospheric boundary layer structure. | WANG Minzhong WEI Wenshou HE Qing YANG Yuhui FAN Lei ZHANG Jiantao | 2016 | Journal of Arid Land2016，8，6： | 17 |
| 2 | Spectral analysis and self-adjusting mechanism for oscillation phenomenon in hydrogen-oxygen continuously rotating detonation engine显示文摘The continuously rotating detonation engine(CRDE)is a new concept of engines for aircraft and spacecraft.Quasi-stable continuously rotating detonation(CRD)can be observed in an annular combustion chamber,but the sustaining,stabilizing and adjusting mechanisms are not yet clear.To learn more deeply into the CRDE,experimental studies have been carried out to investigate hydrogen-oxygen CRDE.Pressure histories are obtained during each shot,which show that stable CRD waves are generated in the combustor,when feeding pressures are higher than 0.5 MPa for fuel and oxidizer,respectively.Each shot can keep running as long as fresh gas feeding maintains.Close-up of the pressure history shows the repeatability of pressure peaks and indicates the detonation velocity in hydrogen–oxygen CRD,which proves the success of forming a stable CRD in the annular chamber.Spectrum of the pressure history matches the close-up analysis and confirms the CRD.It also shows multi-wave phenomenon and affirms the fact that in this case a single detonation wave is rotating in the annulus.Moreover,oscillation phenomenon is found in pressure peaks and a self-adjusting mechanism is proposed to explain the phenomenon. | Liu Yusi Wang Yuhui Li Yongsheng Li Yang Wang Jianping | 2015 | Chinese Journal of Aeronautics2015，28，3： | 14 |
| 3 | Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12显示文摘Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis(OA).However,how subchondral bone formation is activated and the mechanism by which increased subchondral bone turnover promotes cartilage degeneration during OA remains unclear.Here,we show that the mechanistic target of rapamycin complex 1(mTORC1)pathway is activated in subchondral bone preosteoblasts(Osterix+)from OA patients and mice.Constitutive activation of mTORC1 in preosteoblasts by deletion of the mTORC1 upstream inhibitor,tuberous sclerosis 1,induced aberrant subchondral bone formation,and sclerosis with little-to-no effects on articular cartilage integrity,but accelerated posttraumatic OA development in mice.In contrast,inhibition of mTORC1 in preosteoblasts by disruption of Raptor(mTORC1-specific component)reduced subchondral bone formation and cartilage degeneration,and attenuated post-traumatic OA in mice.Mechanistically,mTORC1 activation promoted preosteoblast expansion and Cxcl12 secretion,which induced subchondral bone remodeling and cartilage degeneration during OA.A Cxcl12-neutralizing antibody reduced cartilage degeneration and alleviated OA in mice.Altogether,these findings demonstrate that mTORC1 activation in subchondral preosteoblasts is not sufficient to induce OA,but can induce aberrant subchondral bone formation and secrete of Cxcl12 to accelerate disease progression following surgical destabilization of the joint.Pharmaceutical inhibition of the pathway presents a promising therapeutic approach for OA treatment. | Chuangxin Lin Liangliang Liu Chun Zeng Zhong-Kai Cui Yuhui Chen Pinling Lai Hong Wang Yan Shao Haiyan Zhang Rongkai Zhang Chang Zhao Hang Fang Daozhang Cai Xiaochun Bai | 2019 | Bone Research2019，7，1： | 12 |
| 4 | Global change and climate-vegetation classification显示文摘Three phrases of the quantitative study of climate-vegetation classification and their characteristics are presented based on the review of advance in climate-vegetation interaction, a key issue of 'global change and terrestrial ecosystems (GCTE)' which is the core project of International Geosphere-Biosphere Programme (IGBP): (i) characterized by the correlation between natural vegetation types and climate; (? characterized by climatic indices which have obviously been restricted to plant ecophysiology; (iii) characterized by coupling both structure and function of vegetation. Thus, the prospective of climate-vegetation classification for global change study in China was proposed, especially the study coupling climate-vegetation classification models with atmospheric general circulation models (GCMs) was emphasized. | Guangsheng Zhou Yuhui Wang | 2000 | Chinese Science Bulletin2000，45，7： | 12 |
| 5 | Distribution feature of terrestrial heat flow densities in the Bohai Basin,East China显示文摘Temperature logging curves at 8 boreholes and well-testing temperature data at 142 boreholes are used to determine geotemperature gradients in the Bohai Basin. The thermal conductivities of 86 rock samples are measured at laboratory and the effects of porosity and temperature are corrected to obtain conductivities in situ. Terrestrial heat flow densities at 76 wells are determined based on these data. The distribution of the heat flow indicates that the terrestrial heat flow in the Bohai Basin is relatively high with an average value of 65.8 mW/m2. This characteristic is caused by the tectonic evolution of the basin. During Cenozoic, the litho-sphere stretched intermittently and the crust thinned so that heat conducted from the mantle increased and formed thermal abnormity at depth beneath the basin. | WANG Liangshu LIU Shaowen XIAO Weiyong LI Cheng LI Hua GUO Suiping LIU Bo LUO Yuhui CAI Dongsheng | 2002 | Chinese Science Bulletin2002，47，10： | 10 |
| 6 | Hollow TiO2-x porous microspheres composed of wellcrystalline nanocrystals for high-performance lithiumion batteries显示文摘 | Chun Wang Faxing Wang Yujuan Zhao Yuhui Li Qin Yue Yupu Liu Yong Liu Ahmed A. Elzatahry Abdullah Al-Enizi Yuping Wu Yonghui Deng Dongyuan Zhao | 2016 | Nano Research2016，9，1： | 8 |
| 7 | Structures of the Bohai Petroliferous Area,Bohai Bay Basin显示文摘This paper, for the first time, deals with a more systematic study of the structures in the Bohaipetroliferous area that covers nearly one third of the Bohai Bay basin. The study mainly involves the effects of preexisting basement faults on the basin formation, the characteristics of basin geometry and kinetics, the modelling of the tectonic-thermal history, the polycyclicity and heterogeneity in the structural evolution and the natural seismic tomographic images of the crust and upper mantle. The authors analyze the features of the dynamic evolution of the basin in the paper and point out that the basin in the Bohai petroliferous area is an extensional pull-apart basin. | CAI Dongsheng LUO Yuhui YAO Changhua HE Jiankun HU Shengbiao LU Huafu WANG Liangshu | 2000 | Acta Geologica Sinica(English Edition)2000，74，3： | 8 |
| 8 | Genetic Mapping of Laminaria japonica and L. Iongissima Using Amplified Fragment Length Polymorphism Markers in a "Two-Way Pseudo- Testcross" Strategy显示文摘 | Yuhui Li Yingxia Yang Jidong Liu Xiuliang Wang Tianxiang Gao Delin Duan | 2007 | Journal of Integrative Plant Biology2007，49，3： | 8 |
| 9 | MiR-29a/b/c regulate human circadian gene hPER1 expression by targeting its 3/UTR显示文摘在哺乳动物的几必要生物进步被生理节奏的节奏调整。不过分子的机制 ofoscillating 这些生理节奏的节奏被揭开了,生理节奏的基因的特定的功能不是很, clear.It 被报导了那由 microRNA 将生理节奏的基因击倒是有用策略探索 circadianrhythms 的功能。在这研究,通过屏蔽途径的前面的生物信息学,我们作为有势力 inhibitorsfor 识别了 miR-29a/b/c 人的生理节奏的基因 hPER1。我们进一步发现 miR-29a/b/c 能直接在人的 A549 房间在 mRNA 和蛋白质表示层次指向 hPER1 3untranslated 区域(UTR ) 和下面调整 hPER1。因此,我们的调查结果建议 hPER1 的表示被 miR-29a/b/c 调整,它可以也为 hPER1 的功能提供新线索。 | Xiyan Zhao Xueqiang Zhu Shuting Cheng Yizhou Xie Zhengrong Wang Yanyou Liu Zhou Jiang Jing Xiao Huiling Guo Yuhui Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 7 |
| 10 | Magnetic yolk-shell structured anatase-based microspheres loaded with Au nanoparticles for heterogeneous catalysis显示文摘磁性的蛋黄壳组织了基于锐钛矿的 microspheres 在磁铁矿粒子上通过连续、灵巧的大音阶的第五音胶化涂层被制作,由退火列在后面处理。在与金 nanoparticles 装载之上,获得的功能的磁性的 microspheres 在向苯乙烯氧化物与非凡的高变换(89.5%) 和选择(90.8%) 催化苯乙烯的 epoxidation 作为异构的催化剂显示出优异性能。这些迷人的材料的构造过程为创造另外的功能的 nanocomposites 展示许多含意,这被相信。 | Chun Wang Junchen Chen Xinran Zhou Wei Li Yong Liu Qin Yue Zhaoteng Xue Yuhui Li Ahmed A. Elzatahry Yonghui Deng Dongyuan Zhao | 2015 | Nano Research2015，8，1： | 7 |
| 11 | Perovskite light-emitting/detecting bifunctional fibres for wearable LiFi communication显示文摘Light fidelity(LiFi),which is emerging as a compelling technology paradigm shifting the common means of highcapacity wireless communication technologies,requires wearable and full-duplex compact design because of its great significance in smart wearables as well as the‘Internet of Things’.However,the construction of the key component of wearable full-duplex LiFi,light-emitting/detecting bifunctional fibres,is still challenging because of the conflicting process between carrier separation and recombination,as well as the highly dynamic film-forming process.Here,we demonstrate light-emitting/detecting bifunctional fibres enabled by perovskite QDs with hybrid components.The hybrid perovskite inks endow fibres with super-smooth QD films.This,combined with the small exciton binding energy and high carrier mobility of perovskite QDs,enables successful integration of electroluminescence and photodetection into monofilaments.The bifunctional fibres possess the narrowest electroluminescence full width at half maximum of ~19 nm and,more importantly,the capability for simultaneously transmitting and receiving information.The successful fabrication of narrow emission full-duplex LiFi fibres paves the way for the fabrication and integration of low crosstalk interoperable smart wearables. | Qingsong Shan Changting Wei Yan Jiang Jizhong Song Yousheng Zou Leimeng Xu Tao Fang Tiantian Wang Yuhui Dong Jiaxin Liu Boning Han Fengjuan Zhang Jiawei Chen Yongjin Wang Haibo Zeng | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 12 | Micro RNA profiles and potential regulatory pattern during the early stage of spermatogenesis in mice显示文摘Spermatogenesis is a complicated and poorly understood process that relies on the precise regulation of the self-renewal and differentiation of spermatogonia. In many organisms, micro RNAs(mi RNAs) are involved in multiple developmental processes as critical regulators of transcriptional and post-transcriptional gene silencing. This study investigated the expression pattern of mi RNAs in type B spermatogonia cells(BSc) and primary spermatocytes(PSc) of mice, using a high-throughput small RNA sequencing system. The results revealed that the expression levels of Let-7 family mi RNAs were remarkably high in both cell types. Furthermore, the expression levels of mi R-21, mi R-140-3p, mi R-103, mi R-30 a, mi R-101 b and mi R-99 b were decreased during the transformation from BSc to PSc. These mi RNAs target vital genes that participate in apoptosis, cell proliferation and differentiation, junction assembly and cell cycle regulation. These results highlight the indispensable role of mi RNAs in spermatogenesis. | LUO MengMeng HAO LiLi HU Fen DONG YaNan GOU LiXia ZHANG WenDian WANG Xin ZHAO YuHui JIA MengChun HU SongNian ZHANG XiuJun | 2015 | Science China(Life Sciences)2015，58，5： | 6 |
| 13 | Molecular Cytogenetic Characterization of a Wheat-Leymus mollis 3D(3Ns) Substitution Line with Resistance to Leaf Rust显示文摘Leymus mollis(Trin.)Pilger(NsNsXmXm,2n?28),a wild relative of common wheat,possesses many potentially valuable traits that could be transferred to common wheat during breeding programs.In this study,the karyotypic constitution of a wheat e L.mollis 3D(3Ns#1)disomic substitution line isolated from the F5progeny of octoploid Tritileymus M842-16 Triticum durum cv.D4286,which was designated as 10DM57,was determined using genomic in situ hybridization(GISH),fluorescent in situ hybridization(FISH),SSR markers,and ESTSTS markers.Screening of mitosis and meiosis showed that 10DM57 had a chromosome karyotype of 2n?42?21II.GISH indicated that10DM57 was a line with 40 chromosomes from wheat and two of the Ns chromosomes from L.mollis,which formed a ring bivalent in pollen mother cells at metaphase I.FISH analysis showed that the chromosome 3D may be replaced by 3Ns#1 in 10DM57.DNA markers,including SSR and EST-STS primers,showed that the pair of wheat chromosome 3D in 10DM57 was substituted by the pair of chromosome 3Ns#1from L.mollis.Evaluation of the agronomic traits showed that,compared with its common wheat relative 7182,10DM57 was resistant to leaf rust while the spike length and number of spikes per plant were improved significantly,which correlated with a higher wheat yield.The new germplasm,10DM57,could be exploited as an intermediate material in wheat genetic and breeding programs. | Yuhui Pang Xinhong Chen Jixin Zhao Wanli Du Xueni Cheng Jun Wu Yanli Li Liangming Wang Jing Wang Qunhui Yang | 2014 | Journal of Genetics and Genomics2014，41，4： | 6 |
| 14 | PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus显示文摘地岬在许多细胞的活动起一个枢轴的作用,并且它的 subcellular 区分提供空间、时间的选择。这里,我们报导由二高度相应的蛋白质 PAQR10 和孕激素和 AdipoQ 受体家庭的 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个模式。PAQR10 和 PAQR11 在 Golgi 仪器是只局部性的。PAQR10/PAQR11 的 Overexpression 刺激基础、导致 EGF 的英皇家空军之阶级最低之兵 phosphorylation 并且以一种剂量依赖者方式增加英皇家空军之阶级最低之兵目标基因的表示。PAQR10/PAQR11 的 Overexpression 显著地提高 HRas, NRas 和 KRas4A 的 Golgi 本地化,然而并非 KRas4B。PAQR10 和 PAQR11 罐头也与 HRas, NRas 和 KRas4A 交往,然而并非 KRas4B。在由 PAQR10/PAQR11 的 overexpression 的 Golgi 仪器的增加的地岬蛋白质处于一个活跃状态。一致地, PAQR10 和 PAQR11 还原剂击倒在 Golgi 仪器的刺激 EGF 的英皇家空军之阶级最低之兵 phosphorylation 和地岬激活。有趣地, PAQR10 和 PAQR11 能与 RasGRP1,地岬的 guanine 核苷酸交换蛋白质,和 RasGRP1 的增加 Golgi 本地化交往。RasGRP1 的 C1 领域为和 PAQR10/PAQR11 的 RasGRP1 的相互作用必要、足够。由 overexpressed PAQR10/PAQR11 的英皇家空军之阶级最低之兵 phosphorylation 的模拟被 RasGRP1 的 downregulation 废除。而且, PC12 房间的区别被 PAQR10/PAQR11 的 overexpression 显著地提高。一起,这研究揭开由 PAQR10 和 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个新范例。 | Ting Jin Qiurong Ding Heng Huang Daqian Xu Yuhui Jiang Ben Zhou Zhenghu Li Xiaomeng Jiang Jing He Weizhong Liu Yixuan Zhang Yi Pan Zhenzhen Wang Walter G Thomas Yan Chen | 2012 | Cell Research2012，22，4： | 6 |
| 15 | Impacts of Climatic Change on River Runoff in Northern Xinjiang of China over Last Fifty Years显示文摘The characteristics of climatic change and river runoff, as well as the response of river runoff to climatic change in the northern Xinjiang are analyzed on the basis of the hydrological and meteorological data over the last 50 years by the methods of Mann-Kendall nonparametric test and the nonlinear regression model. The results show that: 1) The temperature and the precipitation increased significantly in the whole northern Xinjiang, but the precipitation displayed no obvious change, or even a decreasing trend in the northern mountainous area of the northern Xinjiang. 2) River runoff varied in different regions in the northern Xinjiang. It significantly increased in the northern slope of the Tianshan Mountains and the north of the northern Xinjiang (p = 0.05), while slightly increased in the west of the northern Xinjiang. 3) North Atlantic Oscillation (NAO) affects river runoff by influencing temperature and precipitation. The NAO and precipitation had apparent significant correlations with the river runoff, but the temperature did not in the northern Xinjiang. Since the mid-1990s river runoff increase was mainly caused by the increasing temperature in the northern slope of the Tianshan Mountains and the north of the northern Xinjiang. Increased precipitation resulted in increased river runoff in the west of the northern Xinjiang. | YANG Yuhui CHEN Yaning LI Weihong WANG Minzhong SUN Guili | 2010 | Chinese Geographical Science2010，20，3： | 6 |
| 16 | Composition optimized trimetallic PtNiRu dendritic nanostructures as I versatile and active electrocatalysts for alcohol oxidation显示文摘Platinum-based nano crystals are the most effective electrocatalysts for accelerati ng the chemical tran sformatio ns on the anode in direct alcohol fuel cells. To facilitate practical applications and overcome the drawbacks of diverse alcohols, it is significant to develop electrocatalysts with high activities and a wide fuel flexibility. Here, we demonstrate a practicable solution method for fabricating composition tun able trimetallic PtNiRu den dritic nano structures (DNSs) which can serve as versatile and active catalysts for electrooxidatio n of a variety of liquid alcohols. A series of trimetallic DNSs with tun able Pt/Ni/Ru atomic ratios were successfully syn thesized by simply adjusti ng the feeding of precursors. Detailed electrochemical test indicates that, among other compositions, the Pt66Ni27Ru7 DNSs present much superior electroactivity in catalyzing electrooxidation of liquid alcohols in acidic mediums. Specifically, the mass activity and specific activity on the Pt66Ni27Ru7 DNSs, for electrooxidation of methanol, ethanol, and ethylene glycol, are 4.57 and 4.34 times, 3.55 and 3.42 times, and 2.37 and 2.28 times that of the commercial Pt black, respectively. X-ray photoelectron spectroscopy and CO stripping studies reveal the adsorption of CO on these PtNiRu DNSs is much weaker than on pure Pt. Meanwhile, the surface Ru sites can provide neighbouring -OH groups to facilitate the oxidati on and removal of the adsorbed in termediates (-CO) on the surface Pt sites, effectively improvi ng the CO tolera nee of the catalysts. The PtNiRu DNSs also show effectively boosted capacity for breaking the C-C bond in C2-alcohols, showing great potential for fuel-flexible fuel cell applications. | Yan Lu Wei Wang Xiaowei Chen Yuhui Zhang Yanchen Han Yong Cheng Xue-Jiao Chen Kai Liu Yuanyuan Wang Qiaobao Zhang Shuifen Xie | 2019 | Nano Research2019，12，3： | 6 |
| 17 | Effects of Elevated CO_2 and Drought on Plant Physiology, Soil Carbon and Soil Enzyme Activities显示文摘Global climate models have indicated high probability of drought occurrences in the coming future decades due to the impacts of climate change caused by a mass release of CO_2. Thus, climate change regarding elevated ambient CO_2 and drought may consequently affect the growth of crops. In this study, plant physiology, soil carbon, and soil enzyme activities were measured to investigate the impacts of elevated CO_2 and drought stress on a Stagnic Anthrosol planted with soybean(Glycine max). Treatments of two CO_2 levels, three soil moisture levels, and two soil cover types were established. The results indicated that elevated CO_2 and drought stress significantly affected plant physiology. The inhibition of plant physiology by drought stress was mediated via prompted photosynthesis and water use efficiency under elevated CO_2 conditions. Elevated CO_2 resulted in a longer retention time of dissolved organic carbon(DOC) in soil, probably by improving the soil water effectiveness for organic decomposition and mineralization. Drought stress significantly decreased C:N ratio and microbial biomass carbon(MBC), but the interactive effects of drought stress and CO_2 on them were not significant. Elevated CO_2 induced an increase in invertase and catalase activities through stimulated plant root exudation.These results suggested that drought stress had significant negative impacts on plant physiology, soil carbon, and soil enzyme activities,whereas elevated CO_2 and plant physiological feedbacks indirectly ameliorated these impacts. | WANG Yuhui YAN Denghua WANG Junfeng DING Yi SONG Xinshan | 2017 | Pedosphere2017，27，5： | 5 |
| 18 | Research on Mobile Internet Mobile Agent System Dynamic Trust Model for Cloud Computing显示文摘This paper analyzes the reasons for the formation of security problems in mobile agent systems, and analyzes and compares the security mechanisms and security technologies of existing mobile agent systems from the perspective of blocking attacks. On this basis, the host protection mobile agent protection technology is selected, and a method to enhance the security protection of mobile agents (referred to as IEOP method) is proposed. The method first encrypts the mobile agent code using the encryption function, and then encapsulates the encrypted mobile agent with the improved EOP protocol IEOP, and then traces the suspicious execution result. Experiments show that using this method can block most malicious attacks on mobile agents, and can protect the integrity and confidentiality of mobile agents, but the increment of mobile agent tour time is not large. | Weijin Jiang Yang Wang Yirong Jiang Jiahui Chen Yuhui Xu Lina Tan | 2019 | China Communications2019，16，7： | 5 |
| 19 | In Situ Synthesis of Fluorescent Mesoporous Silica–Carbon Dot Nanohybrids Featuring Folate Receptor-Overexpressing Cancer Cell Targeting and Drug Delivery显示文摘Multifunctional nanocarrier-based theranostics is supposed to overcome some key problems in cancer treatment.In this work,a novel method for the preparation of a fluorescent mesoporous silica–carbon dot nanohybrid was developed.Carbon dots(CDs),from folic acid as the raw material,were prepared in situ and anchored on the surface of amino-modified mesoporous silica nanoparticles(MSNs–NH2) via a microwave-assisted solvothermal reaction.The as-prepared nanohybrid(designated MSNs–CDs) not only exhibited strong and stable yellow emission but also preserved the unique features of MSNs(e.g.,mesoporous structure,large specific surface area,and good biocompatibility),demonstrating a potential capability for fluorescence imagingguided drug delivery.More interestingly,the MSNs–CDs nanohybrid was able to selectively target folate receptor-overexpressing cancer cells(e.g.,HeLa),indicating that folic acid still retained its function even after undergoing the solvothermal reaction.Benefited by these excellent properties,the fluorescent MSNs–CDs nanohybrid can be employed as a fluorescence-guided nanocarrier for the targeted deliveryof anticancer drugs(e.g.,doxorubicin),thereby enhancing chemotherapeutic efficacy and reducing side effects.Our studies may provide a facile strategy for the fabrication of multifunctional MSN-based theranostic platforms,which is beneficial in the diagnosis and therapy of cancers in future. | Shuai Zhao Shan Sun Kai Jiang Yuhui Wang Yu Liu Song Wu Zhongjun Li Qinghai Shu Hengwei Lin | 2019 | Nano-Micro Letters2019，11，2： | 5 |
| 20 | The association between early-onset cardiac events caused by neoadjuvant or adjuvant chemotherapy in triple-negative breast cancer patients and some novel autophagy-related polymorphisms in their genomic DNA: a real-world study显示文摘Background:An increasing number of cancer patients die of cardiovascular diseases.The cardiotoxicity of chemo-therapy is particularly important in triple-negative breast cancer(TNBC)with limited therapeutic options.Cardiac autophagy is an important mechanism of cardiotoxicity.This research was aimed to investigate the cardiotoxicity of chemotherapy in TNBC,screen the susceptible population,and determine the relationship between cardiotoxicity and autophagy-related polymorphisms.Methods:From a total of 2450 stage I-III TNBC patients,147 met the inclusion criteria and finally recruited.Electro-cardiography(ECG)was performed before most chemotherapy cycles,and echocardiography(UCG)was performed according to clinical needs.All ECG and UCG records were re-interpreted by cardiologists at the National Center for Cardiovascular Disease,Fuwai Hospital.According to the National Center for Biotechnology Information and the Catalog of Somatic Mutations in Cancer database,we selected 25 single nucleotide polymorphisms(SNPs)related to autophagy and genotyped the 147 TNBC patients.Paired-sample T tests,Chi squared tests,and logistic regression models were employed for the analysis.Results:Only 46(31.3%)patients had normal ECG records after every chemotherapy cycle.Among the 16 patients who underwent UCG,2(12.5%)had a reversible decrease of left ventricular ejection fraction.The use of anthracyclines and excessive alcohol consumption were risk factors of ECG abnormalities.With the continuation of chemotherapy,heart rate gradually increased.Anthracyclines were associated with QRS duration abnormalities(P=0.043).After genotyping for 25 autophagy-related SNPs,we found that the G allele of autophagy-related 13(ATG13)rs10838611 was significantly associated with ECG abnormalities(odds ratio=2.258,95%confidence interval=1.318-3.869;P=0.003).Conclusion:ECG abnormalities caused by chemotherapy are common in the real world.Autophagy-related SNPs are associated with chemotherapy-induced cardiotoxicity,thereby providing new evidence for autophagy as a cause of chemotherapy-induced cardiac damage. | Binliang Liu Tao An Meiying Li Zongbi Yi Chunxiao Li Xiaoying Sun Xiuwen Guan Lixi Li Yanfeng Wang Yuhui Zhang Binghe Xu Fei Ma Yixin Zeng | 2018 | Cancer Communications2018，38，1： | 5 |
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