|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endovascular treatment of blood blister-like aneurysms in the internal carotid artery using a Willis covered stent显示文摘Background Despite the current availability of flow diverter devices(FDD), problems remains regarding optimal endovascular treatment(EVT) for blood blister-like aneurysms(BBAs) of the internal carotid artery(ICA). Objective To evaluate the safety and efficacy of EVT of BBAs in the ICA with a Willis covered stent. Methods 20 consecutive patients(5 men and 15 women) with ruptured BBAs underwent EVT using a Willis covered stent in two institutions from March 2013 to March 2018. Clinical observations, angiographic characteristics, and procedural and follow-up outcomes were retrospectively evaluated. Results 20 consecutive patients(5 men and 15 women) with ruptured BBAs underwent EVT using a Willis covered stent in two institutions from March 2013 to March 2018. Clinical observations, angiographic characteristics, and procedural and follow-up outcomes were retrospectively evaluated. Conclusion Our initial results demonstrate that reconstructive EVT using a Willis covered stent provides a viable approach to treat ICA BBAs. However, an expanded clinical evaluation and larger cohort are needed to confirm the results. | Yi Gu Binxian Gu Yongdong Li Yueqi Zhu Haitao Lu Liming Wei Mo Chen Minhua Li Jieqing Wan Wu Wang | 2018 | Journal of Interventional Medicine2018，1，3： | 8 |
| 2 | Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global crisis,urgently necessitating the development of safe,efficacious,convenient-to-store,and low-cost vaccine options.A major challenge is that the receptor-binding domain(RBD)-only vaccine fails to trigger long-lasting protective immunity if used alone for vaccination. | Shiyu Sun Yueqi Cai Tian-Zhang Song Yang Pu Lin Cheng Hairong Xu Jing Sun Chaoyang Meng Yifan Lin Haibin Huang Fang Zhao Silin Zhang Yu Gao Jian-Bao Han Xiao-Li Feng Dan-Dan Yu Yalan Zhu Pu Gao Haidong Tang Jincun Zhao Zheng Zhang Jiaming Yang Zhenxiang Hu Yang-Xin Fu Yong-Tang Zheng Hua Peng | 2021 | Cell Research2021，31，9： | 7 |
| 3 | Polymorphisms of chemokine receptors and its ligand alleles influencing genetic suscepti-bity to HIV-1 infection in eight ethnic groups in Chinese mainland显示文摘Limited genetic information is available concerning the polymorphisms of HIV-1 resistant genes in indigenous Chinese populations. The aim of this study is to identify the allelic frequencies of the chemokine and chemokine receptor genes in the Chinese mainland. Genomic DNA samples extracted from whole blood of 2318 subjects were analyzed by using PCR or PCR/restriction fragment length polymorphism (RFLP) assays, and further confirmed by direct DNA sequencing. Higher frequencies of mutant CCR2-64I (19.15%-28.79%) and SDF1-3’A (19.10% -29.86%) alleles were found in subjects of 8 ethnic groups in the Chinese mainland. In contrast, the △32 mutation in CCRS gene occurs at a very low frequency (0.0016, n=1287) in Han population. A relatively high frequency of CCR5-wt/△32 heterozygotes was observed in Uygurian and Mongolian populations. No A32 mutation allele was detected in Tibetan and other 4 ethnic groups in Yunnan Province. There was no CCR5-m303 mutation in subjects of any ethnic group in the Chinese | WANG Fusheng JIN lei LIU Mingxu HONG Weiguo SHI Hong LEI Zhouyun WANG Jiming DU Qingyou HOU Jing ZHANG Bing JIANG Jiandong WANG Yue LI Yueqi XU Anlong HUANG Honglian LIU Fajun | 2001 | Chinese Science Bulletin2001，46，12： | 6 |
| 4 | Expansive arterial remodeling of carotid arteries in symptomatic ischemic patients显示文摘Purpose: The present study aimed to assess the associations of expansive remodeling of carotid arteries with ischemic symptoms and the degree of stenosis. Materials and Methods: A total of 41 symptomatic patients with vulnerable plaques and 25 asymptomatic individuals with stable plaques were included. All patients underwent 3.0T high-resolution MRI of the carotid artery(CA) for measuring the expansive remodeling(ER) ratio and assessing plaque stability. The ER ratio was calculated by dividing the maximum distance between the lumen and the outer border of the plaque in the internal CA by the lumen diameter within 1 centimeter of the plaque at the distal ipsilateral internal CA. ER ratios were compared between the symptomatic and asymptomatic groups. The 41 symptomatic patients were further divided into 4 groups according to stenosis rate(CA stenosis <50%, 50%–74%, 75–89%, and > 90%), and the correlation between the ER ratio and the rate of stenosis was evaluated. Results: There was a significant difference in ER ratio between the symptomatic and asymptomatic groups(p<0.001). When symptomatic patients were divided into 4 subgroups based on degree of stenosis, ER ratios among groups showed statistically significant differences(p=0.014). Conclusion: There were significant associations of the ER ratio with ischemic symptoms. Furthermore, the ER ratio in symptomatic patients continued to increase with stenosis severity. These findings suggested that the ER ratio might be a practical marker of plaque vulnerability in the CA and further prospective studies for asymptomatic patients are warranted. | Zheyi Chen Mei Li Minghua Li Yuwu Zhao Yueqi Zhu | 2018 | Journal of Interventional Medicine2018，1，2： | 5 |
| 5 | A reactive oxygen species-responsive dendrimer with low cytotoxicity for efficient and targeted gene delivery显示文摘Nonviral vectors have been attracting more attention for several advantages in gene delivery and the development of nonviral gene ca rriers with high delivery efficiency and low cytotoxicity has long been a key project.Starburst polyamidoamine dendrimers are a class of synthetic polymers with unique structural and physical characteristics.However,when they are used as gene carrier,the gene transfection efficiency is not satisfactory.Herein,a novel thioketal-core polyamidoamine dendrimer(i.e.,ROS-PAMAM)was synthesized and characterized.Compared to ethylenediamine-core dendrimers or widely used cationic polymers of polyetherimide,ROS-PAMAM showed lower cytotoxicity.Moreover,ROS-PAMAM demonstrated reactive oxygen species responsive characteristics,which can facilitate the release of siRNA in the tumor microenvironment.In vitro gene transfection experiments based on A549 cells confirmed that siRNA/ROS-PAMAM exhibits high gene transfection efficiency.It is concluded that ROS-PAMAM shows great potential as a generalizable vehicle for gene therapy applications. | Yueqi Wang Changjian Li Libo Du Yang Liu | 2020 | Chinese Chemical Letters2020，31，1： | 5 |
| 6 | Lipid Oxidation and Fatty Acid Composition in Salt-Dried Yellow Croaker(Pseudosciaena polyactis) During Processing显示文摘Lipid oxidation in salt-dried yellow croaker(Pseudosciaena polyactis) was evaluated during processing with commonly used analytical indices, such as the peroxide value(POV), the thiobarbituric acid reactive substances(TBARS) value, and oxidative-relative lipoxygenase(LOX) activity. Additionally, fatty acids were analyzed using gas chromatography-mass spectrometry. Both POV and TBARS increased significantly(P < 0.05) at the rinsing stage. POV reached its peak value of 3.63 meq O_2 per kg sample at the drying stage, whereas TBARS constantly increased from 0.05 to 0.20 mg MDA per kg sample. Processing of salt-dried yellow croaker had an extremely significant(P < 0.01) effect on LOX activity. Twenty-six fatty acids were identified. Combined eicosapentaenoic acid(EPA; C20:5n3) and docosahexaenoic acid(DHA; C22:6n3) content varied between(19.20 ±0.37) mg g^(-1) and(23.45 ± 1.05) mg g^(-1). The polyunsaturated fatty acid/saturated fatty acid(PUFA/SFA) ratio in yellow croaker was 0.73–1.10, and the n-6/n-3 PUFA ratio was approximately 0.13–0.20. The contents of most fatty acids varied significantly(P <0.05) during the different processing stages, and these differences were caused by lipid oxidation. C18:0, C16:1n7, C19:0, and C22:6n3 showed clear changes in principle component one of a principle components analysis. These fatty acids are potential markers for evaluating lipid oxidation in fish muscle because there was a significant correlation between these markers and TBARS and LOX activity(P < 0.05) with Pearson's coefficients > 0.931. | CAI Qiuxing WU Yanyan LI Laihao WANG Yueqi YANG Xianqing ZHAO Yongqiang | 2017 | Journal of Ocean University of China2017，16，5： | 5 |
| 7 | Fault-Tolerant Control of a CPG-Governed Robotic Fish显示文摘Fault tolerance is essential for the maneuverability of self-propelled biomimetic robotic fish in real-world aquatic applications.This paper explores the fault-tolerance control problem of a free-swimming robotic fish with multiple moving joints and a stuck tail joint.The created control system is composed of two main components:a feedback controller and a feedforward compensator.Specifically,the bio-inspired central pattern generator-based feedback controller is designed to make the robotic fish robust to external disturbances,while the feedforward compensator speeds up the convergence of the overall control system.Simulations are performed for control system analysis and performance validation of the faulty robotic fish.The experimental results demonstrate that the proposed fault-tolerant control method is able to effectively regulate the faulty robotic fish,allowing it to complete the desired motion in the presence of damage and thereby improving both the stability and the lifetime of the real robotic system. | Yueqi Yang Jian Wang Zhengxing Wu Junzhi Yu | 2018 | Engineering2018，4，6： | 5 |
| 8 | Atypical features and treatment choices in bipolar disorders:a result of the National Bipolar Mania Pathway Survey in China显示文摘In this study,we examined the point prevalence rate of atypical features in bipolar disorder,and estimated the potential impact of these features on treatment practices in China. Using the atypical features criteria of the Diagnostic and Statistical Manual of the American Psychiatric Association(DSM-IV),we documented the atypical symptoms in 3 906 consecutive participants with bipolar disorder enrolled at 26 psychiatric services across China. We further assessed the association between atypical features and the treatment approaches,including the prescription of antidepressants. The overall point prevalence rate of atypical features was 9.1% among patients with various bipolar disorder subtypes. When the definition was broadened to include atypical features B,the overall rate increased to 11.8%. Interestingly,among patients with the mixed state and remission subtypes,there was a significant difference in the rates of antidepressant medication usage between patients who met and those who did not meet the criteria for atypical features B. These fi ndings indicate a trend of using antidepressants for these two types of patients with atypical features. Further,for both mixed state and remission patients,treatment approaches were related to atypicalfeatures B. Our findings provide evidence to assist clinicians to readily recognize atypical features in bipolar subtypes and can propose treatments based on these diagnoses. | Daihui Peng Ting Shen Linda Byrne Chen Zhang Yueqi Huang Xin Yu Jingping Zhao Marita McCabe David Mellor Yiru Fang | 2015 | Neuroscience Bulletin2015，31，1： | 4 |
| 9 | Bone-targeted pH-responsive cerium nanoparticles for anabolic therapy in osteoporosis显示文摘Antiresorptive drugs are widely used for treatment of osteoporosis and cancer bone metastasis,which function mainly through an overall inhibition of osteoclast.However,not all osteoclasts are“bone eaters”;preosteoclasts(pOCs)play anabolic roles in bone formation and angiogenesis through coupling with osteoblasts and secreting platelet derived growth factor-BB(PDGF-BB).In this study,a bone-targeted pH-responsive nanomaterial was designed for selectively eliminating mature osteoclasts(mOCs)without affecting pOCs.Biocompatible cerium nano-system(CNS)was guided to the acidic extracellular microenvironment created by mOCs and gained oxidative enzymatic activity.Oxidative CNS decreased the viability of mOCs through accumulating intracellular reactive oxygen species and enhancing calcium oscillation.Non-acid secreting anabolic pOCs were thus preserved and kept producing PDGF-BB,which lead to mesenchymal stem cell osteogenesis and endothelial progenitor cell angiogenesis via PI3K-Akt activated focal adhesion kinase.In treating osteoporotic ovariectomized mice,CNS showed better protective effects compare with the current first line antiresorptive drug due to the better anabolic effects marked by higher level of bone formation and vascularization.We provided a novel anabolic therapeutic strategy in treating bone disorders with excessive bone resorption. | Ce Dou Jianmei Li Jian He Fei Luo Tao Yu Qijie Dai Yueqi Chen Jianzhong Xu Xiaochao Yang Shiwu Dong | 2021 | Bioactive Materials2021，6，12： | 3 |
| 10 | Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway显示文摘The aberrant changes of fussion/fission-related proteins can trigger mitochondrial dynamics imbalance,which cause mitochondrial dysfunctions and result insulin resistance(IR).However,the relationship between the inner mitochondrial membrane fusion protein optic atrophy 1(Opa1)and hepatic IR as well as the specific molecular mechanisms of signal transduction has not been fully elucidated.In this study,we explore whether abnormalities in the Opa1 cause hepatic IR and whether berberine(BBR)can prevent hepatic IR through the SIRT1/Opa1 signalling pathway.High-fat diet(HFD)-fed mice and db/db mice are used as animal models to study hepatic IR in vivo.IR,morphological changes,and mitochondrial injury of the liver are examined to explore the effects of BBR.SIRT1/Opa1 protein expression is determined to confirm whether the signalling pathway is damaged in the model animals and is involved in BBR treatment-mediated mitigation of hepatic IR.A palmitate(PA)-induced hepatocyte IR model is established in HepG2 cells in vitro.Opa1 silencing and SIRT1 overexpression are induced to verify whether Opa1 deficiency causes hepatocyte IR and whether SIRT1 improves this dysfunction.BBR treatment and SIRT1 silencing are employed to confirm that BBR can prevent hepatic IR by activating the SIRT1/Opa1 signalling pathway.Western blot analysis and JC-1 fluorescent staining results show that Opa1 deficiency causes an imbalance in mitochondrial fusion/fission and impairs insulin signalling in HepG2 cells.SIRT1 and BBR overexpression ameliorates PA-induced IR,increases Opa1,and improves mitochondrial function.SIRT1 silencing partly reverses the effects of BBR on HepG2 cells.SIRT1 and Opa1 expressions are downregulated in the animal models.BBR attenuates hepatic IR and enhances SIRT1/Opa1 signalling in db/db mice.In summary,Opa1 silencing-mediated mitochondrial fusion/fission imbalance could lead to hepatocyte IR.BBR may improve hepatic IR by regulating the SIRT1/Opa1 signalling pathway,and thus,it may be used to treat type-2 diabetes. | Jia Xu Yining Zhang Zhiyi Yu Yueqi Guan Yuqian Lv Meishuang Zhang Ming Zhang Li Chen Xiaoyan Lv Fengying Guan | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 3 |
| 11 | Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering显示文摘A close relationship has been reported to exist between cadherin-mediated cell-cell adhesion and integrin-mediated cell mobility,and protein tyrosine phosphatase 1B(PTP1B)may be involved in maintaining this homeostasis.The stable residence of mesenchymal stem cells(MSCs)and endothelial cells(ECs)in their niches is closely related to the regulation of PTP1B.However,the exact role of the departure of MSCs and ECs from their niches during bone regeneration is largely unknown.Here,we show that the phosphorylation state of PTP1B tyrosine-152(Y152)plays a central role in initiating the departure of these cells from their niches and their subsequent recruitment to bone defects.Based on our previous design of a PTP1B Y152 region-mimicking peptide(152RM)that significantly inhibits the phosphorylation of PTP1B Y152,further investigations revealed that 152RM enhanced cell migration partly via integrinαvβ3 and promoted MSCs osteogenic differentiation partly by inhibiting ATF3.Moreover,152RM induced type H vessels formation by activating Notch signaling.Demineralized bone matrix(DBM)scaffolds were fabricated with mesoporous silica nanoparticles(MSNs),and 152RM was then loaded onto them by electrostatic adsorption.The DBM-MSN/152RM scaffolds were demonstrated to induce bone formation and type H vessels expansion in vivo.In conclusion,our data reveal that 152RM contributes to bone formation by coupling osteogenesis with angiogenesis,which may offer a potential therapeutic strategy for bone defects. | Yong Tang Keyu Luo Yin Chen Yueqi Chen Rui Zhou Can Chen Jiulin Tan Moyuan Deng Qijie Dai Xueke Yu Jian Liu Chengmin Zhang Wenjie Wu Jianzhong Xu Shiwu Dong Fei Luo | 2021 | Bioactive Materials2021，6，7： | 3 |
| 12 | Synergetic PM_(2.5) and O_(3) control strategy for the Yangtze River Delta,China显示文摘PM_(2.5)concentrations have dramatically reduced in key regions of China during the period 2013-2017,while O_(3)has increased.Hence there is an urgent demand to develop a synergetic regional PM_(2.5)and O_(3)control strategy.This study develops an emission-to-concentration response surface model and proposes a synergetic pathway for PM_(2.5)and O_(3)control in the Yangtze River Delta(YRD)based on the framework of the Air Benefit and Cost and Attainment Assessment System(ABaCAS).Results suggest that the regional emissions of NOx,SO_(2),NH3,VOCs(volatile organic compounds)and primary PM_(2.5)should be reduced by 18%,23%,14%,17%and 33%compared with 2017 to achieve 25%and 5% decreases of PM_(2.5)and O_(3)in 2025,and that the emission reduction ratios will need to be 50%,26%,28%,28% and 55%to attain the National Ambient Air Quality Standard.To effectively reduce the O_(3) pollution in the central and eastern YRD,VOCs controls need to be strengthened to reduce O_(3)by 5%,and then NOx reduction should be accelerated for air quality attainment.Meanwhile,control of primary PM_(2.5)emissions shall be prioritized to address the severe PM_(2.5)pollution in the northern YRD.For most cities in the YRD,the VOCs emission reduction ratio should be higher than that for NOx in Spring and Autumn.NOx control should be increased in summer rather than winter when a strong VOC-limited regime occurs.Besides,regarding the emission control of industrial processes,on-road vehicle and residential sources shall be prioritized and the joint control area should be enlarged to include Shandong,Jiangxi and Hubei Province for effective O_(3)control. | Zhaoxin Dong Jia Xing Fenfen Zhang Shuxiao Wang Dian Ding Hongli Wang Cheng Huang Haotian Zheng Yueqi Jiang Jiming Hao | 2023 | Journal of Environmental Sciences2023，，1： | 3 |
| 13 | The role of dendritic cells derived osteoclasts in bone destruction diseases显示文摘The bone is previously considered as a dominant organ involved in the processes of locomotion.However,in the past two decades,a large number of studies have suggested that the skeletal system closely coordinated with the immune system so as to result in the emerging area of'osteoimmunology'.In the evolution of many kinds of bone destruction-related dis-eases,osteoclasts could differentiate from dendritic cells,which contributed to increased expression of osteoclast-related membrane receptors and relatively higher activity of bone destruction,inducing sewere bone destruction under inflammatory conditions.Numerous fac-tors could influence the interaction between osteoclasts and dendritic cells,contributing to the pathogenesis of several bone diseases in the context of inflammation,including both im-munocytes and a large number of cytokines.In addition,the products of osteoclasts released from bone destruction area serve as important signals for the differentiation and activation of immature dendritic cells.Therefore,the border between the dendritic cell-rela ted immune response and osteoclast-related bone destruction has gradually unravelled.Dendritic cells and osteoclasts cooperate with each other to mediate bone destruction and bone remodelling under inflammatory conditions.In this review,we will pay attention to the interactions be-tween dendritic cells and osteoclasts in physiological and pathological conditions to further understand the skeletal system and identifty potential new therapeutic targets for the future by summarizing their significant roles and molecular mechanisms in bone destruction. | Bo Wang Yutong Dong Zhansong Tian Yueqi Chen Shiwu Dong | 2021 | Genes & Diseases2021，8，4： | 2 |
| 14 | Sodium hydroxide-induced esophageal stricture via an endoscopic injection needle: a novel rabbit model of corrosive injury显示文摘Purpose: Benign strictures of the esophagus are commonly encountered in clinical practice and are difficult to manage conservatively. This study aimed to establish a novel animal model of benign esophageal stricture by using corrosive-induced injury in rabbits with an injection of sodium hydroxide(NaOH) via a self-made endoscopic injection needle. Materials and Methods: Corrosive injury of the esophagus was induced in 10 rabbits by administration of 1 mL of 1.5% NaOH using a laryngoscope with a self-made endoscopic injection needle. The self-made injection needle was fabricated by modification of the core of an endoscopic injection needle. The laryngoscope examination was performed at 2 weeks and 4 weeks after induction of corrosive injury; esophagography was also performed at 4 weeks to assesse sophageals tricture.A lla nimalsw eree uthanizedat th een dof the fourth week; the esophagus was removed, and stained sectionsw eree xaminedm icroscopically. Results: Laryngoscope examination at 2 weeks showed ulceration. At the end of fo urth we e k,laryngosco py,r a diolo gical, and gross exa m inations showed successful in ductionof e s ophagea l stric turein a llanimal s,without any c omp licatio n.The m eanst r ic t ure inde x at the en dof fourth week wa s49.54±3. 61%; the mean le ngth of stricture w as18.0± 2.5mm.Micros copicexa mina tionrevea ledf ocalulceratio nand subm ucosalth i cke ning secondary to fibrosis. Conclusion:Rab bit esop hageal stri ctu re induced us ing lary ngosc opy with endosco pic injec tion of a sm all am ount of lowcon centration s odium hyd roxid e is a t echn ica lly simp le,safe,and re produ cible meth od for cre atio n of an animal m odel of esophageal stricture.This model can be useful for developing new treatment methods for esop hageal s tricture. | Kai Yang Xiaofeng Li Bi Zhou Yueqi Zhu Jun cao Bin chen Yingsheng Cheng | 2018 | Journal of Interventional Medicine2018，1，1： | 2 |
| 15 | Inhaled amifostine for the prevention of radiation-induced lung injury显示文摘Objective:To alleviate radiation-induced lung injury and prevent the related pneumonitis and pulmonary fibrosis by inhaled amifostine(AMI).Methods:15 Gy 60Coγ-ray irradiation was performed on the thoracic area of rats once to establish the radiation injury model.AMI was intraperitoneally(i.p.)injected or intratracheally(i.t.)administered to the rats 30 min preirradiation.The protective effects of the two AMI administration manners were compared in the aspects of hematopoietic system,lung edema,and histopathological examination,and the mechanisms were explored.Results:Compared to i.p.AMI,i.t.AMI remarkably alleviated radiation-induced lung injury and prevented consequent pneumonitis or pulmonary fibrosis.Specifically,i.t.AMI notably protected white blood cells and platelets,reduced the lung wet/dry weight ratio,and decreased collagen volume fractions compared to the model group(P<0.05),while i.p.AMI showed no significant difference with the model group(P>0.05).The high therapeutic efficiency of i.t.AMI was related to its high antioxidation and anti-inflammation effects with downregulation of pro-inflammatory cytokines,the enhanced superoxide dismutase activity,the low levels of malondialdehyde and total proteins.Conclusion:Inhaled AMI is a promising medicine for preventing radiation-induced lung injury,including pneumonitis and pulmonary fibrosis. | Ting Chen Bo Zhuang Yueqi Huang Wanmei Wang Yiguang Jin | 2022 | Radiation Medicine and Protection2022，3，2： | 2 |
| 16 | Altered serous levels of monoamine neurotransmitter metabolites in patients with refractory and non-refractory depression显示文摘The study examined plasma metabolite changes of monoamine neurotransmitters in patients with treatment-resistant depression (TRD) and non-TRD before and after therapy. All 30 TRD and 30 non-TRD patients met the diagnostic criteria for a depressive episode in accordance with the International Classification of Diseases, Tenth Revision. Before treatment, and at 4, 6, and 8 weeks after treatment, the plasma metabolite products of monoamine neurotransmitters in TRD group, including 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenyl ethylene glycol and homovanillic acid, were significantly lower than those in the non-TRD group. After two types of anti-depressive therapy with 5-serotonin and norepinephrine reuptake inhibitor, combined with psychotherapy, the Hamilton Depression Rating Scale scores were significantly reduced in both groups of patients, and the serous levels of 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenyl ethylene glycol were significantly increased. In contrast, the homovanillic acid level exhibited no significant change. The levels of plasma metabolite products of peripheral monoamine neurotransmitters in depressive patients may predict the degree of depression and the therapeutic effects of treatment. | Guiqing Zhang Yanxia Zhang Jianxia Yang Min Hu Yueqi Zhang Xia Liang | 2012 | Neural Regeneration Research2012，7，14： | 2 |
| 17 | Atypical features and bipolar disorder显示文摘双相障碍(Bipolar Disorder,BD)临床症状多样,容易被误诊为抑郁症(Major depressive disorder,MDD)。非典型症状(Atypical Features,ATFs)是一个有用的指标,可以从抑郁状态中识别出双相障碍,有助于双相障碍与抑郁症的鉴别诊断。本文就非典型症状与双相障碍的相关性问题进行讨论。 | Daihui PENG Yueqi HUANG Kaida JIANG | 2016 | 上海精神医学2016，28，3： | 2 |
| 18 | Tumor-conditional IL-15 pro-cytokine reactivates anti-tumor immunity with limited toxicity显示文摘IL-15 is a promising cytokine to expand NK and CD8'T cells for cancer immunotherapy,but its application is limited by dose-limiting,on-target off-tumor toxicity.Here,we have developed a next-generation IL 15 that is activated inside the tumor microenvironment(TME).This pro-IL-15 has the extracellular domain of IL-15RP fused to the N-terminus of slL-15-Fc through a tumor-enriched Matrix Metalloproteinase(MMP)cleavable peptide linker to block its activity.Unlike slL-15-Fc,pro-IL-15 does not activate the peripheral expansion of NK cells and T cells,thus reducing systemic toxicity,but it still preserves efficient anti-tumor abilities.In various mouse tumors,the anti-tumor effect of pro-IL-15 depends on intratumoral CD8'T cells and IFN-y-Pro-IL-15 increases the stem-like TCF1^(+)Tim-3 CD8^(+)T cells within tumor tissue and helps overcome immune checkpoint blockade(ICB)resistance.Moreover,pro-IL-15 synergizes with current tyrosine kinase inhibitor(TKI)targeted-therapy in a poorly inflamed TUBO tumor model,suggesting that pro-IL-15 helps overcome targeted-therapy resistance.Our results demonstrate a next-generation IL-15 cytokine that can stimulate potent anti-tumor activity without severe toxicity. | Jingya Guo Yong Liang Diyuan Xue Jiao Shen Yueqi Cai Jiankun Zhu Yang-Xin Fu Hua Peng | 2021 | Cell Research2021，31，11： | 2 |
| 19 | Active ammonia-oxidizing bacteria and archaea in wastewater treatment systems显示文摘Ammonia-oxidizing bacteria(AOB)and archaea(AOA)are two microbial groups mediating nitrification,yet little is presently known about their abundances and community structures at the transcriptional level in wastewater treatment systems(WWTSs).This is a significant issue,as the numerical abundance of AOA or AOB at the gene level may not necessarily represent their functional role in ammonia oxidation.Using amo A genes as molecular markers,this study investigated the transcriptional abundance and community structure of active AOA and AOB in 14 WWTSs.Quantitative PCR results indicated that the transcriptional abundances of AOB amo A(averaged:1.6×10^(8)copies g^(-1)dry sludge)were higher than those of AOA(averaged:3.4×10^(7)copies g^(-1)dry sludge)in all WWTSs despite several higher abundances of AOA amo A at the gene level.Moreover,phylogenetic analysis demonstrated that Nitrosomonas europaea and unknown clusters accounted for 37.66%and 49.96%of the total AOB amo A transcripts,respectively,suggesting their dominant role in driving ammonia oxidation.Meanwhile,AOA amo A transcripts were only successfully retrieved from 3 samples,and the Nitrosospaera sister cluster dominated,accounting for 83.46%.Finally,the substrate utilization kinetics of different AOA and AOB species might play a fundamental role in shaping their niche differentiation,community composition,and functional activity.This study provides a basis for evaluating the relative contributions of ammonia-oxidizing microorganisms(AOMs)to nitrogen conversions in WWTSs. | Maosheng Zheng Shishi He Yueqi Feng Mingyuan Wang Yong-Xin Liu Chenyuan Dang Jiawen Wang | 2021 | Journal of Environmental Sciences2021，33，4： | 2 |
| 20 | Ultra-small nanodots coated with oligopeptides providing highly negative charges to enhance osteogenic differentiation of hBMSCs better than osteogenic induction medium显示文摘For bone regenerative engineering,it is a promising method to form skeletal tissues differentiating from human bone morrow mesenchyme stem cells(hBMSCs).However,it is still a critical challenge to efficiently control ostogenesis and clearly reveal the influence factor.To this end,the fluorescent gold nanodots(Au NDs) with highly negative charges as osteogenic induction reagent are successfully synthesized,which display better than commercial osteogenic induction medium through the investigations of ALP activity(2.5 folds) and cytoskeleton staining(1.5 folds).Two kinds of oligopeptides with different bio-structures(cysteine,Cys and glutathione,GSH) are selected for providing surficial charges on Au NDs.It is revealed that Au-Cys with more negative charges(-51 mV) play better role than Au-GSH(-19 mV) in osteogenic differentiation,when both of them have same size(~2 nm),sphere shape and show similar cell uptake amount.To explore deeply,osteogenesis related signaling pathways are monitored,revealing that the enhancement of osteogenic differentiation was through autophagy signaling pathway triggered by Au-Cys.And the promotion of highly negative charges in osteogenic diffe rentiation was further proved via sliver nanodots(Ag NDs,Ag-Cys and Ag-GSH) and carbon nanodots(CDs,Cys-CDs and GSH-CDs).This work indicates part of insights during hBMSCs differentiation and provides a novel strategy in osteogenic differentiation process. | Yueqi Zhao Lin Meng Kai Zhang Yuanqing Sun Yue Zhao Zhe Yang Yangliu Lin Xinrui Liu Hongchen Sun Bai Yang Quan Lin | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员