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| 1 | Graphene oxide as a water transporter promoting germination of plants in soil显示文摘Graphene 氧化物(去) 是生纳入基础飞机并且到 graphene 格子的边的各种各样的包含氧的功能的组的 graphene 衍生物,因此,众多的恐水病的 sp 2 在聚类的唯一的结构在吸水的 sp 3 公司矩阵以内被孤立。在这研究,吸水的性质和搬运水的性质去被利用支持工厂的萌芽和生长。它被发现那低剂量变显著地在土壤支持了菠菜和细香葱的萌芽。包含氧的功能的组变镇定水,和搬运的恐水病的 sp 2 领域流水到种子加速植物的萌芽。在之间的强壮的相互作用去,稳定的土壤谷物的表面在土壤和阻止的驱散去去。另外,不去在表面上或在工厂的房间内被检测;这发现证实了那去不是 phytotoxic。因此,去可以用作有希望的无毒的添加剂增加工厂收益。 | Yijia He Ruirui Hu Yujia Zhong Xuanliang Zhao Qiao Chen Hongwei Zhu | 2018 | Nano Research2018，11，4： | 20 |
| 2 | Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO显示文摘胃的溃疡(GU ) 是在全世界影响许多人的普通病理。过多的白酒消费是 GU 的主要原因之一;然而,仍然有为 GU 的预防或治疗的有效的药的缺乏。在这研究,我们在老鼠把保护的效果和 kaempferol (KAE ) 的可能的机制与尖锐导致乙醇的损害作比较到胃的 mucosa。Fasted 老鼠口头上地被给车辆(0.9% 盐) , omeprazole (20 mg/kg ) ,或为在在由有绝对乙醇(10 ml/kg ) 的挑战的 GU 模型的建立以前的不同试验性的集合的 1 h 的 KAE (40, 80,或 160 mg/kg ) 。动物是 euthanized 在乙醇吸入以后的 1 h,和他们的血浆和胃纸巾服从于进一步的检查。宏观、显微镜的损害,和免疫学的和生物化学的参数被观察。发炎的效果用下列指示物被调查:肿瘤坏死因素 --(TNF-) , interleukin-1 (IL-1 ) , IL-6, myeloperoxidase (军邮局) ,和氮的氧化物(没有) 。结果证明 KAE 显著地减少了溃疡索引,增加了预防索引,完全保护了 mucosa 免受损害,和保存胃的 mucosal glycoprotein 的伤害。KAE 减少了军邮局活动和支持 inflammatory cytokine (TNF- ,和 IL-1 ) 铺平,并且没改进层次。KAE 的 gastroprotective 活动可能被归因于胃的有粘液的 glycoproteins 层次的保藏,这样由禁止嗜中性的累积和军邮局活动,调整支持 inflammatory cytokines 的层次,并且不改进生产。 | Qinchen Li Xinxin Hu Yanhan Xuan Jianghua Ying Yujia Fei Jielu Rong Yong Zhang Jian Zhang Chunyan Liu Zheng Liu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 18 |
| 3 | Enhancing both selectivity and coking-resistance of a single-atom Pd1/C3N4 catalyst for acetylene hydrogenation显示文摘选择加氢是在化学升级的一个重要工业催化过程,在因为他们的高加氢活动,基于 Pd 的催化剂广泛地被使用的地方。然而,因为重焦炭形成,差的选择和短催化剂一生是主要担心。在这个工作,原子地驱散 Pd 原子成功地在 graphitic 碳氮化物上被综合(g-C 3 用原子层免职的 N 4) 。没有 Pd nanoparticle (NP ) ,改正错误的高角度的环形的黑暗地的扫描传播电子显微镜学(HAADF 茎) 证实了孤立的 Pd 原子的主导的存在形成。在在过量乙烯的乙炔的选择加氢期间, g-C 3 N 4-supported Pd NP 催化剂比常规 Pd/Al 2 O 3 和 Pd/SiO 2 催化剂。在原处, X 光检查光致核裂变光谱学表明可观的费用从 Pd NP 转到 g-C 3 N 4 多半在催化表演改进起一个重要作用。更给人深刻印象地,单个原子的 Pd 1/C3 N 4 催化剂展出了两种更高的乙烯选择和更高的 coking 抵抗。我们的工作证明单个原子的 Pd 催化剂是在加氢反应改进选择和焦炭抵抗的一个有希望的候选人。 | Xiaohui Huang Yujia Xia Yuanjie Cao Xusheng Zheng Haibin Pan Junfa Zhu Chao Ma Hengwei Wang Junjie Li Rui You Shiqiang Wei Weixin Huang Junling Lu | 2017 | Nano Research2017，10，4： | 16 |
| 4 | Single crystalline CH_3NH_3PbI_3 self-grown on FTO/TiO_2 substrate for high efficiency perovskite solar cells显示文摘Since its first report in 2009,CH_3NH_3PbI_3-based perovskite solar cells(PSCs)have emerged as one of the most exciting developments in the next generation photovoltaic(PV)technologies[1],with its PV conversion efficiency(PCE)rising spectacularly from3.81% to 22.1% in just 7 years.Such rapid advance is | Jinjin Zhao Guoli Kong Shulin Chen Qian Li Boyuan Huang Zhenghao Liu Xingyuan San Yujia Wang Chen Wang Yunce Zhen Haidan Wen Peng Gao Jiangyu Li | 2017 | Science Bulletin2017，62，17： | 12 |
| 5 | NEW EQUATIONS OF SEDIMENT TRANSPORT RATE显示文摘NEWEQUATIONSOFSEDIMENTTRANSPORTRATEWANGShiqiang;ZHANGRenandHUIYujia(ProfDept.ofHydraulicEngrg.TsinghuaUniversity,Beijing,Chin... | WANG Shiqiang ZHANG Ren and HUI Yujia( Dept.of Hydraulic Engrg.Tsinghua University,Beijing,China)( Dept of Hydraulic Engrg..Tsinghua University, Beijing, China)( Dept.of Hydraulic Engrg.Tsinghua University, Beijing, China) | 1995 | International Journal of Sediment Research1995，10，3： | 10 |
| 6 | Metal-Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications显示文摘Investigation of metal–organic frameworks(MOFs)for biomedical applications has attracted much attention in recent years.MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure,ultrahigh surface area and porosity,tunable pore size,and easy chemical functionalization.In this review,the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first section.Then,state-ofthe-art strategies to functionalize MOFs with therapeutic agents were summarized,including surface adsorption,pore encapsulation,covalent binding,and functional molecules as building blocks.In the third section,the most recent biological applications of MOFs for intracellular delivery of drugs,proteins,and nucleic acids,especially aptamers,were presented.Finally,challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems. | Yujia Sun Liwei Zheng Yu Yang Xu Qian Ting Fu Xiaowei Li Zunyi Yang He Yan Cheng Cui Weihong Tan | 2020 | Nano-Micro Letters2020，12，8： | 10 |
| 7 | Removal of Pb(Ⅱ) from aqueous solution by hydrous manganese dioxide:Adsorption behavior and mechanism显示文摘Hydrous manganese dioxide (HMO) synthesized by redox of potassium permanganate and hydrogen peroxide was used as an adsorbent for Pb(Ⅱ) removal.The specific surface area,pore volume and BJH pore diameter of the HMO were 79.31m2/g,0.07cm3/g and 3.38 nm,respectively.The adsorption equilibrium at 298K could be well described by the Langmuir isotherm equation with q max value of 352.55mg/g.The negative values of G and the positive values of H and S indicated the adsorption process was spontaneous and endothermic.The pseudo second-order equation could best fit the adsorption data.The value of the calculated activation energy for Pb(Ⅱ) adsorption onto the HMO was 38.23 kJ/mol.The uptake of Pb(Ⅱ) by HMO was correlated with increasing surface hydroxyl group content and the main adsorbed speciation was PbOH+.The final chemical state of Pb(Ⅱ) on the surface of HMO was similar to PbO.HMO was a promising candidate for Pb(Ⅱ) removal from aqueous solution. | Meng Xu Hongjie Wang Di Lei Dan Qu Yujia Zhai Yili Wang | 2013 | Journal of Environmental Sciences2013，25，3： | 9 |
| 8 | Fura-2/AM法测定突触体内游离Ca^(2+)浓度的方法显示文摘采用新型Ca2+荧光指示剂Fura-2,测定冷冻伤性脑水肿时突触体内游离钙的离子浓度。 | Chen Liuhua Yan Yujia He Zhengwen, et al(Neurological and Neurosurgical Institute of Ncurosurgery, Xiangya Hospital, Hunan Medical University, Changsha 410008) | 1998 | 湖南医科大学学报1998，23，4： | 9 |
| 9 | Characterization and fine mapping of an early senescence mutant (es-t) in Oryza sativa L.显示文摘An es-t (early senescence-temporary) mutant, produced by ethylene methylsulfonate treatment of strain Nipponbare, was identified in rice. The leaves of es-t appeared yellow at the seedling stage, and had decreased chlorophyll content. Rust spots were found during growth in es-t, especially at the leaf margin and tip. The plants showed a typical early-senescence phenotype at the milky stage. The leaf surface of es-t appeared smoother than wild-type leaves under a scanning electron microscope, because the leaves lack siliceous protuberances around the stoma. Chloroplasts grow abnormally and are filled with many starch grains in es-t. Paraffin section analysis showed that the development of the sclerenchyma cells and vascular bundles were also abnormal in es-t. Genetic analysis indicated that es-t was controlled by a recessive gene, which was finely mapped to a 42-kb interval on chromosome 5. These results will facilitate the positional cloning and functional studies of the gene. | YANG YaoLong RAO YuChun LIU HuiJuan FANG YunXia DONG GuoJun HUANG LiChao LENG YuJia GUO LonBiao ZHANG GuangHeng HU Jiang GAO ZhenYu QIAN Qian ZENG DaLi | 2011 | Chinese Science Bulletin2011，56，23： | 8 |
| 10 | A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells显示文摘 | Yujia Mao Shanshan Yin Jianmin Zhang Yu Hu Bo Huang Lianxian Cui Ning Kang Wei He | 2016 | Cellular & Molecular Immunology2016，13，2： | 8 |
| 11 | Human monoclonal antibodies as candidate therapeutics against emerging viruses显示文摘 | Yujia Jin Cheng Lei Dan Hu Dimiter S. Dimitrov Tianlei Ying | 2017 | Frontiers of Medicine2017，11，4： | 8 |
| 12 | Molecular feature and therapeutic perspectives of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome显示文摘Regulatory T(Treg) cells, a subtype of immunosuppressive CD4^+T cells, are vital for maintaining immune homeostasis in healthy people. Forkhead box protein P3(FOXP3), a member of the forkhead-wingedhelix family, is the pivotal transcriptional factor of Treg cells. The expression, post-translational modifications, and protein complex of FOXP3 present a great impact on the functional stability and immune plasticity of Treg cells in vivo. In particular, the mutation of FOXP3 can result in immune dysregulation,polyendocrinopathy, enteropathy, X-linked(IPEX) syndrome, which is a rare genetic disease mostly diagnosed in early childhood and can soon be fatal. IPEX syndrome is related to several manifestations,including dermatitis, enteropathy, type 1 diabetes, thyroiditis, and so on. Here, we summarize some recent findings on FOXP3 regulation and Treg cell function. We also review the current knowledge about the underlying mechanism of FOXP3 mutant-induced IPEX syndrome and some latest clinical prospects.At last, this review offers a novel insight into the role played by the FOXP3 complex in potential therapeutic applications in IPEX syndrome. | Qianru Huang Xu Liu Yujia Zhang Jingyao Huang Dan Li Bin Li | 2020 | Journal of Genetics and Genomics2020，47，1： | 8 |
| 13 | Genetic evidence for asymmetric blocking of higher-order chromatin structure by CTCF/cohesin显示文摘Dear Editor,Similar to higher-order folding of polypeptide chains into functional proteins,linear DNA molecules are spatially folded in a hierarchical and dynamic manner into three-dimensional(3D)functional chromatin structures in eukaryotic nuclei(Huang and Wu,2016;Rowley and Corces,2018).This dynamic folding is closely related to many nuclear processes such as DNA replication and repair,chromosomal translocation,recombination,and segregation,as well as RNA transcription,splicing,and transport.In particular,dynamic long-distance chromatin looping interactions,which result in close spatial contacts between distal enhancers and target promoters,are thought to play a role in controlling precise spatiotemporal as well as cell-type specific gene expression during animal development(Rowley and Corces,2018).Mammalian genomes contain numerous noncoding regulatory elements that regulate these dynamic long-distance chromatin looping interactions. | Yujia Lu Jia Shou Zhilian Jia Yonghu Wu Jinhuan Li Ya Guo Qiang Wu | 2019 | Protein & Cell2019，10，12： | 7 |
| 14 | Gap junction-mediated cell-to-cell communication in oral development and oral diseases: a concise review of research progress显示文摘Homoeostasis depends on the close connection and intimate molecular exchange between extracellular, intracellular and intercellular networks. Intercellular communication is largely mediated by gap junctions(GJs), a type of specialized membrane contact composed of variable number of channels that enable direct communication between cells by allowing small molecules to pass directly into the cytoplasm of neighbouring cells. Although considerable evidence indicates that gap junctions contribute to the functions of many organs, such as the bone, intestine, kidney, heart, brain and nerve, less is known about their role in oral development and disease. In this review, the current progress in understanding the background of connexins and the functions of gap junctions in oral development and diseases is discussed. The homoeostasis of tooth and periodontal tissues, normal tooth and maxillofacial development, saliva secretion and the integrity of the oral mucosa depend on the proper function of gap junctions.Knowledge of this pattern of cell–cell communication is required for a better understanding of oral diseases. With the everincreasing understanding of connexins in oral diseases, therapeutic strategies could be developed to target these membrane channels in various oral diseases and maxillofacial dysplasia. | Wenjing Liu Yujia Cui Jieya Wei Jianxun Sun Liwei Zheng Jing Xie | 2020 | International Journal of Oral Science2020，12，2： | 7 |
| 15 | Recent advances in organic-based materials for resistive memory applications显示文摘With the rapid development of data-driven human interaction,advanced datastorage technologies with lower power consumption,larger storage capacity,faster switching speed,and higher integration density have become the goals of future memory electronics.Nevertheless,the physical limitations of conventional Si-based binary storage systems lag far behind the ultrahigh-density requirements of post-Moore information storage.In this regard,the pursuit of alternatives and/or supplements to the existing storage technology has come to the forefront.Recently,organic-based resistive memory materials have emerged as promising candidates for next-generation information storage applications,which provide new possibilities of realizing high-performance organic electronics.Herein,the memory device structure,switching types,mechanisms,and recent advances in organic resistive memory materials are reviewed.In particular,their potential of fulfilling multilevel storage is summarized.Besides,the present challenges and future prospects confronted by organic resistive memory materials and devices are discussed. | Yang Li Qingyun Qian Xiaolin Zhu Yujia Li Mayue Zhang Jingni Li Chunlan Ma Hua Li Jianmei Lu Qichun Zhang | 2020 | InfoMat2020，2，6： | 7 |
| 16 | Lipid metabolism in cartilage and its diseases:a concise review of the research progress显示文摘The homeostasis of the vertebrate body depends on anabolic and catabolic activities that are closely linked the inside and outside of the cell.Lipid metabolism plays an essential role in these metabolic activities.Although a large amount of evidence shows that normal lipid metabolism guarantees the conventional physiological activities of organs in the vertebrate body and that abnormal lipid metabolism plays an important role in the occurrence and deterioration of cardiovascular-related diseases,such as obesity,atherosclerosis,and type II diabetes,little is known about the role of lipid metabolism in cartilage and its diseases.This review aims to summarize the latest advances about the function of lipid metabolism in cartilage and its diseases including osteoarthritis,rheumatoid arthritis,and cartilage tumors.With the gradual in-depth understanding of lipid metabolism in cartilage,treatment methods could be explored to focus on this metabolic process in various cartilage diseases. | Yueyi Yang Jieya Wei Jiachi Li Yujia Cui Xuedong Zhou Jing Xie | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 7 |
| 17 | Cage slip characteristics of a cylindrical roller bearing with a trilobe-raceway显示文摘Based on dynamic analysis of rolling bearings, the nonlinear dynamic differential equations of a cylindrical roller bearing with a trilobe-raceway were established and solved by the GSTIFF(gear stiff) integer algorithm with a variable step. The influences of structural parameters and the tolerance of the trilobe-raceway, working conditions of the bearing, and the outer ring installation method on cage slip characteristics were investigated. The results show that:(i) The cage slip ratio and bearing rating life of a cylindrical roller bearing with a trilobe-raceway would reduce when the low-radius(radius of the outer raceway contour at the lowest point) and D-value(difference value between the high and low points of the outer raceway contour) decrease, and the former(low-radius) contributes more significantly.(ii) The cage slip ratio of a cylindrical roller bearing with a trilobe-raceway rises with the increase of the bearing speed, and decreases with the increase of the radial force; the variation range increases with the increase of the low-radius.(iii) When the installation angle of the outer ring increases in a period, the cage slip ratio remains unchanged while the bearing rating life rises up a little. Therefore, when installing a cylindrical roller bearing with a trilobe-raceway, the location of the maximum radius shall be under that of the radial force to improve the bearing rating life.(iv) With the increase of the roundness of the base circle where the radius of the lowest points of the trilobe-raceway contour locates, the cage slip ratio rises gradually and the bearing rating life decreases. | Sier DENG Yujia LU Wenhu ZHANG Xue SUN Zhenwei LU | 2018 | Chinese Journal of Aeronautics2018，31，2： | 7 |
| 18 | Growth of ZnO self-converted 2D nanosheet zeolitic imidazolate framework membranes by an ammoniaassisted strategy显示文摘塑造象金属那样的水晶的多孔的材料器官的框架(MOF ) 和沸石进二维(2D ) nanosheet 形成为开发高效的分子的 sieving 膜是高度合乎需要的。然而,常规脱落免职为 nanosheet MOF 管状的膜的大规模制造复杂、挑战性。第一次,这里,我们由 ZnO 自我变换和氨帮助报导一种直接生长技术制作 zeolitic imidazolate 框架(ZIF ) 膜在多孔的空纤维底层上由 2D nanosheets 组成;膜对大规模工业煤气的分离过程合适。为 ZIF nanosheet 膜的建议制造过程在作为一个调节的人包含铵氢氧化物的一个 ligand 答案基于 ZnO 的预先扔的薄层的局部性的自我变换。产生 ZIF 2D nanosheet 管状的膜是高度面向的并且仅仅在厚度的 50 nm。它展出优秀分子的 sieving 性能,与为 H 2/CO2 分离的高 H 2 渗入和选择。这种技术为大规模分子的 sieving 应用在 MOF nanosheet 膜制造显示出大诺言。 | Yujia Li Lu Lin Min Tu Pei Nian Ashlee J. Howarth Omar K. Farha Jieshan Qiu Xiongfu Zhang | 2018 | Nano Research2018，11，4： | 6 |
| 19 | Motility-based label-free detection of parasites in bodily fluids using holographic speckle analysis and deep learning显示文摘Parasitic infections constitute a major global public health issue.Existing screening methods that are based on manual microscopic examination often struggle to provide sufficient volumetric throughput and sensitivity to facilitate early diagnosis.Here,we demonstrate a motility-based label-free computational imaging platform to rapidly detect motile parasites in optically dense bodily fluids by utilizing the locomotion of the parasites as a specific biomarker and endogenous contrast mechanism.Based on this principle,a cost-effective and mobile instrument,which rapidly screens~3.2 mL of fluid sample in three dimensions,was built to automatically detect and count motile microorganisms using their holographic time-lapse speckle patterns.We demonstrate the capabilities of our platform by detecting trypanosomes,which are motile protozoan parasites,with various species that cause deadly diseases affecting millions of people worldwide.Using a holographic speckle analysis algorithm combined with deep learningbased classification,we demonstrate sensitive and label-free detection of trypanosomes within spiked whole blood and artificial cerebrospinal fluid(CSF)samples,achieving a limit of detection of ten trypanosomes per mL of whole blood(~five-fold better than the current state-of-the-art parasitological method)and three trypanosomes per mL of CSF.We further demonstrate that this platform can be applied to detect other motile parasites by imaging Trichomonas vaginalis,the causative agent of trichomoniasis,which affects 275 million people worldwide.With its costeffective,portable design and rapid screening time,this unique platform has the potential to be applied for sensitive and timely diagnosis of neglected tropical diseases caused by motile parasites and other parasitic infections in resource-limited regions. | Yibo Zhang Hatice Ceylan Koydemir Michelle M.Shimogawa Sener Yalcin Alexander Guziak Tairan Liu Ilker Oguz Yujia Huang Bijie Bai Yilin Luo Yi Luo Zhensong Wei Hongda Wang Vittorio Bianco Bohan Zhang Rohan Nadkarni Kent Hill Aydogan Ozcan | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 20 | Significance and expression of Bax, Survivin and p53 in gastric carcinoma and precancerous lesions using tissue microarray显示文摘Objective: To explore the relationship between expressions of apoptosis-related protein Bax, Survivin and p53 and the molecular mechanisms of carcinogenesis and progression of gastric carcinoma. Methods: Tissue microarray and immunohistochemistry were used in this study. Results: The positive rate of Bax protein in gastric cancer (17.7%,17/96) was significantly lower than those in adjacent normal mucosa (51%), intestinal metaplasia (69.2%) and dysplasia (75%), P < 0.01. The positive rate of Survivin expression in gastric cancer (80.6%, 89/98) was significantly higher than that in adjacent normal mucosa (3.9%), P < 0.01. The positive rates of Survivin expression in tumors with different organ metastases (in lymph node metastasis 86.2%, liver 100% and ovarian 100%) were statistically higher than in tumors without metastasis (64.3%), P < 0.05. Bax expression was correlated with Survivin but not with mp53 that was closely related to Survivin expression (P < 0.05) in gastric cancer. Conclusion: The abnormal expressions of Bax, Survivin and mp53 were correlated with the tumorigenesis and progression of gastric carcinoma. P53 and Survivin genes may share the similar mechanism in regulating cell apoptosis, and because of the mutation, p53 gene may lower its down-regulation to Survivin expression. | Yuping Xiao Zhi Lin Lili Mao Dongying Wu Yujia Gao Hongwei Sun Yan Xin | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，4： | 5 |
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