|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Isolation and Structure Elucidation of Autolytimycin, A New Compound Produced by Streptomyces Autolyticus JX-47显示文摘Autolytimycin 1 was isolated from the culture filtrate of Streptomyces autolyticus JX-47, together with two known compounds, lebstatin 2 and 17-O-demethyl-geldanamycin 3. These compounds showed the activities of anti-HSV-I. The structure of 1 was determined by spectral analysis. | Li, MG Wu, SH Zhao, LX Zhang, Q Li, WJ Cui, XL Xu, LH Wu, DG Jiang, CL | 2001 | Chinese Chemical Letters2001，12，10： | 10 |
| 2 | Establishment of an orthotopic transplantation tumor model of hepatocellular carcinoma in mice显示文摘AIM:To improve the outcome of orthotopic transplantation in a mouse model,we used an absorbable gelatin sponge(AGS) in nude mice to establish an orthotopic implantation tumor model.METHODS:MHCC-97L hepatocellular carcinoma(HCC)cells stably expressing the luciferase gene were injected into the subcutaneous region of nude mice.One week later,the ectopic tumors were harvested and transplanted into the left liver lobe of nude mice.The AGS was used to establish the nude mouse orthotopic implantation tumor model.The tumor suppressor gene,paired box gene 5(PAX5),which is a tumor suppressor in HCC,was transfected into HCC cells to validate the model.Tumor growth was measured by bioluminescence imaging technology.Semi-quantitative reverse transcription polymerase chain reaction(RT-PCR) and histopathology were used to confirm the tumorigenicity of the implanted tumor from the MHCC-97L cell line.RESULTS:We successfully developed an orthotopic transplantation tumor model in nude mice with the use of an AGS.The success rate of tumor transplantation was improved from 60% in the control group to 100% in the experimental group using AGS.The detection of fluorescent signals showed that tumors grew in all live nude mice.The mice were divided into 3 groups:AGS-,AGS+/PAX5-and AGS+/PAX5 +.Tumor size was significantly smaller in PAX5 transfected nude mice compared to control mice(P < 0.0001).These fluorescent signal results were consistent with observations made during surgery.Pathologic examination further confirmed that the tissues from the ectopic tumor were HCC.Results from RT-PCR proved that the HCC originated from MHCC-97L cells.CONCLUSION:Using an AGS is a convenient and efficient way of establishing an indirect orthotopic liver transplantation tumor model with a high success rate. | Gui-Jun Zhao Li-Xia Xu Eagle SH Chu Ning Zhang Jia-Yun Shen Alatangaole Damirin Xiao-Xing Li | 2012 | World Journal of Gastroenterology2012，18，47： | 4 |
| 3 | Intraspinal transplantation of CD34+ human umbilical cord blood cells after spinal cord hemisection injury improves functional recovery in adult rats显示文摘 | Zhao,ZM Li,HJ Liu,HY Lu,SH Yang,RC Zhang,QJ Han,ZC | 2005 | 中国生物学文摘2005，19，3： | 2 |
| 4 | Microbial communities in the larval midgut of laboratory and field populations of cotton bollworm (Helicoverpa armigera)显示文摘 | Hui XA Wei GF Jia SH Huang JH Miao XX Zhou Z Zhao LP Huang YP | 2007 | 中国生物学文摘2007，21，6： | 2 |
| 5 | Synthesis, crystal structure, and insecticidal activities of highly congested hexahydroimidazo pyridine Derivatives: Effect of Conformation on Activities显示文摘 | Shao X Sh Xu Z P Zhao X F | 2010 | J Agric Food Chem2010，58，： | 1 |
| 6 | Entrepreneurial Orien- tation, Organizational Learning, and Performance: Evi- dence From China显示文摘 | Zhao YB Li Y Lee SH Chen LB | 2011 | Entrepreneurship Theory and Prac- tice2011，35，2： | 1 |
| 7 | Application of ultrasound to selectively localize nanodroplets for targeted imaging and therapy 显示文摘 | DAYTON PA ZHAO S BLOCH SH | 2006 | Molecular Imaging2006，5，3： | 1 |
| 8 | Specific immunotherapy suppresses Th2 responses via modulating TIM1/ TIM4 interaction on dendritic cells显示文摘 | Zhao CQ Li TL He SH Chen X An YF Wu WK | 2010 | Allergy2010，65，8： | 1 |
| 9 | FoxM1 expression is significantly associated with cisplatin-based chemotherapy resistance and poor prognosis in advanced non-small cell lung cancer patients显示文摘 | Wang Y Wen L Zhao SH | 2013 | Lung Cancer2013，79，2： | 1 |
| 10 | Effect of radiation on cytotoxicity,apoptosis and cell cycle arrest of human osteosarcoma MG-63 induced by a ruthenium(Ⅱ)complex显示文摘 | Liu SH Zhao JH Deng KK | 2015 | Spectrochim Acta A Mol Biomol Spectrosc2015，140，： | 1 |
| 11 | Management of primary angle-closure glaucoma by phacoemul-sification with foldable posterior chamber intraocular lens implantation显示文摘 | Wu JH Liu L Zhao SH Zhong M | 2008 | Zhejiang Da xue xue Bao Yi xue Ban2008，37，4： | 1 |
| 12 | Optimization of Cr^4+ - doped saturable-absorber Q-switched lasers 显示文摘 | ZHANG X Y ZHAO Sh Zh WANG Q P | 1997 | IEEE J Q E1997，33，12： | 1 |
| 13 | Effects of daintain/AIF-1 on beta cell dysfunction in 1NS-1 cells 显示文摘 | Huang XY Zhao YY Jia SH | 2011 | Biosci Biotechnol Biochem2011，75，9： | 1 |
| 14 | Specific immunotherapy suppresses Th2 responses via modulating TIM1/TIM4 interaction on dendritic cells显示文摘 | Zhao CQ Li TL He SH | 2010 | Allergy2010，65，8： | 1 |
| 15 | New measurement principle of in-line fast speed inspection for vehicle gear 显示文摘 | SHI ZH Y ZHAO SH ZH TANG J | 2005 | Modern Components2005，，10： | 1 |
| 16 | Effects of different kinds of salt in comutagenicity and growth of cancer cells显示文摘 | ZHAO X KIM SH QI YC | | 0，，01： | 1 |
| 17 | NAULP inflmmasome functional polynlorphisms and gout susceptibility显示文摘 | Miao ZM Zhao SH Yan SL | | 0，，： | 1 |
| 18 | Quantifying the impacts of socio-economic factors on air quality in Chinese cities from 2000 to 2009显示文摘 | Zhao J J Chen Sh B Wang H | 2012 | Environmental Pollution2012，167，： | 1 |
| 19 | A differentiable shepp-logan phantom and its applications in exact cone-beam CT显示文摘 | YU H Y ZHAO SH Y WANG G | 2005 | Physics in Medicine and Biology2005，50，11： | 1 |
| 20 | Identification and preliminary function study of Xenopus laevis DRR1 gene显示文摘 | Zhao XY Liang SF Yao SH | 2007 | Biochem Biophys Res Commun2007，361，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员