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| 1 | Global secretome analysis identifies novel mediators of bone metastasis显示文摘骨头是稳固的肿瘤的远转移的一个最普通的地点。分泌蛋白质被知道影响在变形癌症房间和骨头基质之间的病理学的相互作用。为了包括地介绍,分泌了与骨头转移联系的蛋白质,我们使用了量、非量的集体 spectrometry 全球性分析改变从多重种类和癌症的变形能力打的骨头的九根细胞线的 secretomes。由比较父母房间和他们的骨头的 secretomes 变形衍生物,我们识别了特别地在这些房间线与骨头转移被联系的分泌蛋白质。我们然后合并了大临床的转移数据集的生物信息的分析获得强烈与临床、试验性的骨头转移被联系的几个功能的班的候选人小说骨头转移蛋白质的一张表。选择蛋白质的功能的确认显示在 vivo,骨头转移能被高表示支持(1 ) 唾液的 cystatins CST1, CST2,和 CST4;(2 ) plasminogen 使活跃之物小块地和 PLAU;或(3 ) 骨胶原功能蛋白质 PLOD2 和 COL6A1。总的来说,我们的学习揭开了骨头转移并且因此的几个新分泌调停人证明 secretome 分析是为新奇 biomarkers 和候选人的鉴定的一个强大的方法治疗学的目标。 | Maria Andres Blanco Gary LeRoy Zia Khan Ma a Ale kovi Barry M Zee Benjamin A Garcia Yibin Kang | 2012 | Cell Research2012，22，9： | 12 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Polypharmacy and falls in older peo- ple: Balancing evidence-based medi- cine against falls risk 显示文摘 | Zia A Kamaruzzaman SB Tan MP | 2015 | Postgrad Med2015，127，3： | 1 |
| 4 | Copper uptake and regulation in a copper-tolerant decapod Cambarusbartoni(Fabricius)(Decapoda,Crustacea)显示文摘 | Zia S Alikhan M A | 1989 | Bulletin of Environmental Contamination and Toxicology1989，42，1： | 1 |
| 5 | Acute respiratory and systemic toxicity of pulmo nary exposure to rutile Fe-doped TiO2 nanorods显示文摘 | Nemmar A Melghit K AI-Salam S Zia S Dhanasekaran S At toub S et aI | 2011 | Toxicolo gy2011，279，13： | 1 |
| 6 | Ventilator-associated tracheobronchitis:the'impact of targeted antibiotic therapy on patientoutcomes 显示文摘 | Craven DE Chmneou A Zias NV | 2009 | Chest2009，135，： | 1 |
| 7 | Modification of cellulosic fabric using polyvinyl alcohol,Part?Ⅱ:colorfastness properties显示文摘 | ZUBER M ZIA KM BHATTI I A | 2012 | Carbohyd Polym2012，87，4： | 1 |
| 8 | XRD studies of polyurethane elastomers based on chitin/1,4-butane diol blends 显示文摘 | Zia K M Bhatti I A | 2009 | Carbohydrate Polymers2009，76，： | 1 |
| 9 | Percutaneous locking plates for fractures of the distal tibia: our experience and a review of the litera- ture显示文摘 | Ahmad M A Sivaraman A Zia A | 2012 | J Trauma Acute Care Surg2012，72，2： | 1 |
| 10 | Control theoretic approach to tracking radar: first step towards cognition显示文摘 | Haykin S Zia A Xue Y | 2011 | Digital Signal Processing2011，21，6： | 1 |
| 11 | Effect of passive ultrasonic irrigation and manual dynamic irrigation on smear layer removal from root canals in a closed apex in vitro model 显示文摘 | Andrabi MUN Kumar A Zia A | 2014 | Journal of Investigative & Clinical Dentistry2014，5，3： | 1 |
| 12 | Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells显示文摘 | Ndoye A Nguyen VT | 1997 | Res Commun Mol Pathol Pharmacol1997，97，： | 1 |
| 13 | MHC class Ⅰ negative phenotype of disseminated tumor cells in bone narrow is associated with poor survival in ROMO breast cancer patients显示文摘 | Zia A Schidberg FW Funke I | 2001 | Int Cancer2001，93，4： | 1 |
| 14 | Accountability in Governance Networks:An Assessment of Public,Private,and Nonprofit Emergency Management Practices Following Hurricane Katrina显示文摘 | KOLIBA · C · J MILLS · R · M ZIA · A | | 0，，02： | 1 |
| 15 | Application of LabVIEW and CRIOfor high precision positioning of mars rover using DC motors 显示文摘 | Zia M T Curley A Duran 0 | 2011 | Space Technology2011，，9： | 1 |
| 16 | Compliance with hepatitis B virus vaccination and risk of occupational exposure to blood and other body fluids in intensive care department personnel in Brazil显示文摘 | Vania F.C Manso Kézia F Castro Sirley M Matos Ana Luiza N Junqueira Sandra B Souza Márcia M Sousa Regina M.B Martins Sheila A Teles | 2003 | AJIC: American Journal of Infection Control2003，，7： | 1 |
| 17 | Ventilator-associated tra- cheo-bronchitisThe impact of targeted antibiotic therapy on patient out-comes显示文摘 | Craven DE Chroneou A Zias N | 2009 | Chest2009，135，2： | 1 |
| 18 | Effect of passive ultrasonic irriga- tion and manual dynamic irrigation on smear layer removal from root canals in a closed apex in vitro model显示文摘 | Andrabi SM Kumar A Zia A | 2013 | J Investig Clin Dent2013，，： | 1 |
| 19 | Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role ofNAD(P)H oxidase显示文摘 | Zia MT Csiszar A Labinskyy N | 2009 | Stroke2009，40，： | 1 |
| 20 | An EM algorithm for nonlinear state estimation with model uncertainties显示文摘 | Zia A Kirubarajan T Reilly J P | 2008 | IEEE Transactions on Signal Processing2008，56，3： | 1 |
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