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| 1 | Mesoproterozoic age for Xiamaling Formation in North China Plate indicated by zircon SHRIMP dating显示文摘Zircon grains of magmatic origin from tuffite layers in the Xiamaling Formation at Zhaojiashan Village, Xuanhua area, Hebei Province, were used for zircon dating with a Sensitive High-Resolution Ion Microprobe (SHRIMP II), which gives a weighted mean 207Pb/206Pb age of 1366±9 Ma. It shows a very similar age (1368±12 Ma) as the zircon dating from the Xiamaling Formation in Western Hill, Beijing. This age proposes that the Xiamaling Formation in the North China plate should be of Mesoproterozoic, instead of Neoproterozoic based on K-Ar, Ar-Ar dating. The new zircon age also indicates the devel- opment of macrofossils algae from the Mesoproterozoic age. | GAO LinZhi ZHANG ChuanHeng SHI XiaoYing SONG Biao WANG ZiQiang LIU YaoMing | 2008 | Chinese Science Bulletin2008，53，17： | 68 |
| 2 | A New SHRIMP Age of the Xiamaling Formation in the North China Plate and Its Geological Significance显示文摘建立 hypostratotype 近来前寒武纪是关于中央的研究的主要目的 -- 并且在诺思中国的 Neoproterozoic。chronostratigraphic 位置是在这研究的钥匙。然而,许多关键地平线没与高质量的同位素的年龄被校准。用有敏感高分辨率的离子 Microprobe (虾 II ) 的报导新 U-Pb 年龄,锆石 U-Pb 年龄在诺思中国板中在 Xiamaling 形成灰床被获得,产出 1368+-12 妈的加权的吝啬的 ^(206 )Pb/^(238 ) U 年龄。现在是从在北方中国板中的 Xiamaling 形成的第一虾 U-Pb 年龄,并且代表 Xiamaling 形成的中间的部分的扔的时间。锆石年龄起一个重要作用到在中央期间理解北方中国板的地质的进化 -- 并且 Neoproterozoic。 | GAO Linzhi ZHANG Chuanheng SHI Xiaoying ZHOU Hongrui WANG Ziqiang SONG-Biao | 2007 | Acta Geologica Sinica(English Edition)2007，81，6： | 35 |
| 3 | Coordinated regulation of apical hook development by gibberellins and ethylene in etiolated Arabidopsis seedlings显示文摘当在土壤发芽时,当通过土壤耸出时,黑暗成年的 Arabidopsis 幼苗开发一个顶端的钩,它保护子叶和顶端的 meristematic 纸巾。几荷尔蒙被报导清楚地调制这个过程。以前的研究证明了乙烯和赤霉素(气体) 并列地调整钩发展,尽管内在的分子的机制大部分是未知的。当 paclobutrazol 镇压了时,这里,我们显示出提高的那 GA 3 ethylene-overexpression 和 EIN3-overexpression (EIN3ox ) 导致了钩弯曲,并且 della 异种展出了夸大的钩弯曲,它要求了发信号的未经触动的乙烯小径。基因学习表明那提高 GA 的钩开发依赖于无钩 1 (HLS1 ) ,调停的一个中央管理者多重发信号小径的输入在顶端的钩开发期间。我们进一步发现那 GA 3 导致(并且 DELLA 蛋白质镇压了) 在乙烯感觉迟钝的 3/EIN3-LIKE 的 HLS1 表示 1 (EIN3/EIL1 ) 依赖举止, EIN3/EIL1 由此激活 HLS1 抄写由对它的倡导者直接有约束力。另外, DELLA 蛋白质被发现与 EIN3/EIL1 的 DNA 有约束力的领域交往并且镇压 EIN3/EIL1-regulated HLS1 表示。有 naphthylphthalamic 酸的处理,一个极的植物生长素运输禁止者,镇压 EIN3ox 线的组成地夸大的钩弯曲和 della 异种,支持那植物生长素在钩开发乙烯和 GA 小径下游地工作。一起拿,我们的结果作为联系 DELLA 的抄写因素的一个新类识别 EIN3/EIL1 并且证明 GA 由经由 EIN3/EIL1 函数的 derepression 导致 HLS1 的表达式部分与乙烯在合作支持顶端的钩形成。 | Fengying An Xing Zhang Ziqiang Zhu Yusi Ji Wenrong He Zhiqiang Jiang Mingzhe Li Hongwei Guo | 2012 | Cell Research2012，22，5： | 34 |
| 4 | Octoradiate Spiral Organisms in the Ediacaran of South China显示文摘摘要:华南的 Ediacaran Doushantuo 形成的页岩包含新扁圆形 macrofossil, Eoandromeda octobrachiata,用可能是在外部膜以内的 housed 的八只螺线手臂描绘了。尽管八放射的结构的存在必要相似到 cnidarian octocorals 以及到栉水母,与这些现存的组一起的直接相同是不大可能的。相反,我们从 Doushantuo 形成把注意带到最新报导的胚胎的 helicospiral 形态学,建议 Ediacaran 胚胎的 metazoans 的长寻求的成年人最后被发现了。 | TANG Feng YIN Chongyu Stefan BENGTSON LIU Pengju WANG Ziqiang GAO Linzhi | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 29 |
| 5 | A new discovery of macroscopic fossils from the Ediacaran Doushantuo Formation in the Yangtze Gorges area显示文摘Two new horizons with macroscopic fossils are reported in the Doushantuo Formation, Ediacaran System, from the Yangtze Gorges area. The fossils were discovered in the lower and middle black shales of the Doushantuo Formation in the new section at Sandouping Town, Zigui County, Hubei Province. The new macroscopic assemblages in- clude Chuaria and Tawuia, and occur below the well- known ”Miaohe Biota”. These fossils indicate that after the Nantuo ice age, macroscopic multicellular organisms gradually increased in abundance and diversity. Simple, discoidal carbonaceous compres- sions such as chuarids are present in the initial macrofossil assemblage of the Doushantuo Stage. This assemblage was eventually replaceded by the more diverse Miaohe macrofossils, including unam- biguously branching forms, in the uppermost Dou- shantuo Formation. The new discovery of carbona- ceous compression macrofossils from the Doushan- tuo Formation in the Yangtze Gorges area provides new evidence for the correlation of late Neoprotero- zoic successions in southern China. | TANG Feng YIN Chongyu Bengtson Stefan LIU Yongqing WANG Ziqiang LIU Pengju GAO Linzhi | 2006 | Chinese Science Bulletin2006，51，12： | 23 |
| 6 | Position and complications of pedicle screw insertion with or without image-navigation techniques in the thoracolumbar spine:a meta-analysis of comparative studies显示文摘Computer-navigated pedicle screw insertion is applied to the thoracic and lumbar spine to attain high insertion accuracy and a low rate of screw-related complications.However,some in vivo and in vitro studies have shown that no advantages are gained with the use of navigation techniques compared to conventional techniques.Additionally,inconsistent conclusions have been drawn in various studies due to different population characteristics and methods used to assess the accuracy of screw placement.Moreover,it is not clear whether pedicle screw insertion with navigation techniques decreases the incidence of screw-related complications.Therefore,this study was sought to perform a meta-analysis of all available prospective evidence regarding pedicle screw insertion with or without navigation techniques in human thoracic and lumbar spine.We considered in vivo comparative studies that assessed the results of pedicle screw placement with or without navigation techniques.PubMed,Ovid MEDLINE and EMBASE databases were searched.Three published randomized controlled trials(RCTs) and nine retrospective comparative studies met the inclusion criteria.These studies included a total of 732 patients in whom 4,953 screws were inserted.In conclusion,accuracy of the position of grade I,II,III and IV screws and complication rate related to pedicle screw placement were significantly increased when navigation techniques were used in comparison to conventional techniques.Future research in this area should include RCTs with well-planned methodology to limit bias and report on validated,patient-based outcome measures. | Jinshan Tang Ziqiang Zhu Tao Sui Dechao Kong Xiaojian Cao | 2014 | The Journal of Biomedical Research2014，28，3： | 15 |
| 7 | Effect of dilution holes on the performance of a triple swirler combustor显示文摘A triple swirler combustor is considered to be a promising solution for future high temperature rise combustors. The present paper aims to study dilution holes including primary dilution holes and secondary dilution holes on the performance of a triple swirler combustor. Experimental investigations are conducted at different inlet airflow velocities(40–70 m/s) and combustor overall fuel–air ratio with fixed inlet airflow temperature(473 K) and atmospheric pressure. The experimental results show that the ignition is very difficult with specific performance of high ignition fuel–air ratio when the primary dilution holes are located 0.6H(where H is the liner dome height)downstream the dome, while the other four cases have almost the same ignition performance. The position of primary dilution holes has an effect on lean blowout stability and has a large influence on combustion efficiency. The combustion efficiency is the highest when the primary dilution holes are placed 0.9H downstream the dome among the five different locations.For the secondary dilution holes, the pattern factor of Design A is better than that of Design B. | Ding Guoyu He Xiaomin Zhao Ziqiang An Bokun Song Yaoyu Zhu Yixiao | 2014 | Chinese Journal of Aeronautics2014，27，6： | 13 |
| 8 | Biodegradable mineralized collagen plug for the reconstruction of craniotomy burr‐holes:A report of three cases显示文摘Objectives: In this case report, we describe the design, fabrication and clinical outcomes of a novel bioresorbable, mineralized collagen burr‐hole plug for the reconstruction of craniotomy burr‐holes. Methods: Mineralized collagen burr‐hole plugs were fabricated via a biomimetic mineralization process. The biomimetic mineralized collagen has a similar chemical composition and microstructure to natural bone tissue, thereby possessing good biocompatibility and osteoconductivity. The mineralized collagen burr‐hole plugs were implanted into three patients, and clinical outcomes were evaluated at one‐year follow‐ups. Results: All bone defects healed very well using the mineralized collagen burr‐hole plugs, and there were no adverse reactions at the surgical sites. Conclusions: The clinical outcomes indicated that the mineralized collagen was effective for reconstructing burr‐holes in the skull after craniotomy. | Zhiye Qiu Yuqi Zhang Ziqiang Zhang Tianxi Song Fuzhai Cui | 2015 | Translational Neuroscience and Clinics2015，1，1： | 13 |
| 9 | An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men显示文摘Objective To investigate the associations of hormone circulation with phthalate exposure in adult men. Methods Semen and serum samples were collected from 118 men who were suspected of infertility. Phthalate diesters including dibutyl phthalate (DBP) and diethylhexyl phthalate (DEHP) in both semen and serum samples were measured, along with serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), estradiol (E 2 ) and prolactin (PRL). Results Serum PRL was positively associated with serum DBP and DEHP and semen DEHP in all models of Spearman correlation, linear regression and binary logistic regression. In linear regression models adjusted for potential confounders and excluding subjects with undetectable phthalates, a 10‐fold increase in semen DEHP was associated with a 23% increase in serum PRL, as well as a 26% increase in serum DBP and a 20% increase in serum DEHP. In logistic regression models all subjects demonstrated a dose‐response relationship between above reference value PRL and semen DEHP (odds ratio per tertile adjusted for potential confounders = 1.0, 1.70, 3.50; P for trend = 0.01), and serum DBP (1.0, 1.10, 2.62; P for trend = 0.04), and serum DEHP (1.0, 1.46, 4.69; P for trend < 0.01). A positive correlation between serum estradiol and semen DEHP (linear regression), and an inverse correlation between semen DBP and serum testosterone and T:E 2 ratio (Spearman correlation) were also established. Conclusions Serum PRL is suggested to be positively associated with both DBP and DEHP exposure in adult men. | LI ShuGuang DAI JiCan ZHANG LiQian ZHANG Jing ZHANG ZiQiang CHEN Bo | 2011 | Biomedical and Environmental Sciences2011，24，1： | 12 |
| 10 | Structure Design of Lower Limb Exoskeletons for Gait Training显示文摘Due to the close physical interaction between human and machine in process of gait training, lower limb exoskeletons should be safe, comfortable and able to smoothly transfer desired driving force/moments to the patients. Correlatively, in kinematics the exoskeletons are required to be compatible with human lower limbs and thereby to avoid the uncontrollable interactional loads at the human-machine interfaces. Such requirement makes the structure design of exoskeletons very difficult because the human-machine closed chains are complicated. In addition, both the axis misalignments and the kinematic character difference between the exoskeleton and human joints should be taken into account. By analyzing the DOF(degree of freedom) of the whole human-machine closed chain, the human-machine kinematic incompatibility of lower limb exoskeletons is studied. An effective method for the structure design of lower limb exoskeletons, which are kinematically compatible with human lower limb, is proposed. Applying this method, the structure synthesis of the lower limb exoskeletons containing only one-DOF revolute and prismatic joints is investigated; the feasible basic structures of exoskeletons are developed and classified into three different categories. With the consideration of quasi-anthropopathic feature, structural simplicity and wearable comfort of lower limb exoskeletons, a joint replacement and structure comparison based approach to select the ideal structures of lower limb exoskeletons is proposed, by which three optimal exoskeleton structures are obtained. This paper indicates that the human-machine closed chain formed by the exoskeleton and human lower limb should be an even-constrained kinematic system in order to avoid the uncontrollable human-machine interactional loads. The presented method for the structure design of lower limb exoskeletons is universal and simple, and hence can be applied to other kinds of wearable exoskeletons. | LI Jianfeng ZHANG Ziqiang TAO Chunjing JI Run | 2015 | Chinese Journal of Mechanical Engineering2015，28，5： | 11 |
| 11 | Solution-processed copper nanowire flexible transparent electrodes with PEDOT:PSS as binder, protector and oxide-layer scavenger for polymer solar cells显示文摘nanowire (NW ) 拍摄的 Cu 的容易的氧化和表面粗糙是为他们在透明传导性的电极(TCE ) 的用法的主要瓶颈。此处,我们开发了一条灵巧、可伸缩起来的答案线路准备 Cu 由把 Cu NW 嵌进的基于 NW 的 TCE pre 涂 poly 变光滑(3,4-ethylenedioxythiophene ): poly (styrenesulfonate )(PEDOT : PSS ) 电影在上 poly (乙烯 terephthalate )( 宠物) 底层。那么获得的 Cu NW-PEDOT : PSS/PET 电影有低表面粗糙(在高度的 70 nm ) ,向氧化的高稳定性和好灵活性。最佳的 TCE 显示出 15 猯'T? 的一个典型的表电阻 ?? | Jianyu Chen Weixin Zhou Jun Chen Yong Fan Ziqiang Zhang Zhendong Huang Xiaomiao Feng Baoxiu Mi Yaowen Ma Wei Huang | 2015 | Nano Research2015，8，3： | 10 |
| 12 | Trust Access Authentication in Vehicular Network Based on Blockchain显示文摘Data sharing and privacy securing present extensive opportunities and challenges in vehicular network.This paper introducestrust access authentication scheme’as a mechanism to achieve real-time monitoring and promote collaborative sharing for vehicles.Blockchain,which can provide secure authentication and protected privacy,is a crucial technology.However,traditional cloud computing performs poorly in supplying low-latency and fast-response services for moving vehicles.In this situation,edge computing enabled Blockchain network appeals to be a promising method,where moving vehicles can access storage or computing resource and get authenticated from Blockchain edge nodes directly.In this paper,a hierarchical architecture is proposed consist of vehicular network layer,Blockchain edge layer and Blockchain network layer.Through a authentication mechanism adopting digital signature algorithm,it achieves trusted authentication and ensures valid verification.Moreover,a caching scheme based on many-to-many matching is proposed to minimize average delivery delay of vehicles.Simulation results prove that the proposed caching scheme has a better performance than existing schemes based on central-ized model or edge caching strategy in terms of hit ratio and average delay. | Shaoyong Guo Xing Hu Ziqiang Zhou Xinyan Wang Feng Qi Lifang Gao | 2019 | China Communications2019，16，6： | 10 |
| 13 | Genetic Basis of Ethylene Perception and Signal Transduction in Arabidopsis显示文摘Ethylene is a simple gaseous hormone in plants. It plays important roles in plant development and stress tolerance. In the presence of ethylene treatment, all ethylene receptors are in an activated form, which can physically interact with CTR1 and consequently recruit CTR1 protein to endoplasmic reticulum membrane to activate it. Activated CTR1 suppresses the downstream signal transduction by an unknown mechanism. Upon binding to its receptors, ethylene will inactivate the receptor/CTR1 module and in turn alleviate their inhibitory effect on two positive regulators acting downstream of CTR1: EIN2 and EIN3. Genetic study reveals that EIN2 is an essential component in the ethylene signaling pathway but its biochemical function remains a mystery. EIN3 is a plant-specific transcription factor and its protein abundance in the nucleus is rapidly induced upon ethylene treatment. In the absence of ethylene signal, EIN3 protein is degraded by an SCF complex containing one of the two F-box proteins EBF1/EBF2 in a 26S proteasome-dependent manner. EIN3 can bind to the promoter sequences of a number of downstream components, such as ERFs, which in turn bind to a GCC box, a cis-element found in many ethylene-regulated defense genes. Ethylene has been shown to also regulate many other hormones' signaling pathways including auxin, abscisic acid and jasmonic acid, implying the existence of complicated signaling networks in the growth, development and defense responses of various plants. | Ziqiang Zhu Hongwei Guo | 2008 | Journal of Integrative Plant Biology2008，50，7： | 9 |
| 14 | A Passive Anti-icing Strategy Based on a Superhydrophobic Mesh with Extremely Low Ice Adhesion Strength显示文摘Although superhydrophobic materials have attracted much research interest in anti-icing,some controversy still exists.In this research,we report a cost-effective method used to verify the contribution of area fraction to ice adhesion strength.We tried to partially-embed siliea nanopnarticles into microscale fabrics of a commercial polyamide mesh.Then,the area fraction could be determined by altering the mesh size.Generally,the ice adhesion strength decreases as the area fraction decreases.An ice adhesion strength of~1.9 kPa and a delayed freezing time of~1048 s can be obtained.We attribute the low ice adhesion strength to the combination of superhydro-phobicity and stress concentration.The superhydrophobicity prohibits the water from penetrating into the voids of the meshes,and the small actual contact area leads to stress concentration which promotes interfacial crack propagation.Moreover,our superhydrophobic mesh simultaneously exhibis a micro-nano hierarchical structure and a partally-cmbedded structure.Therefore,the as-prepared superhydrophobic mesh retained the ieephobicity after 20 icingldeicing cycles,and maintained its superhydrophobicity even afier 60 sandpaper-abrasion cycles and a 220'C thermal treatment. | Peng Wang Ziqiang Li Qing Xie wei Duan Xinchun Zhang Huilong Han | 2021 | Journal of Bionic Engineering2021，18，1： | 9 |
| 15 | Effect of treatment course of comprehensive intervention with Traditional Chinese Medicine on mortality of acquired immunodeficiency syndrome patients treated with combined antiretroviral therapy显示文摘OBJECTIVE:To investigate the effect of a treatment course of comprehensive intervention with Traditional Chinese Medicine(TCM) on the mortality of patients with acquired immunodeficiency syndrome(AIDS) treated with combined antiretroviral therapy(c ART).METHODS:AIDS patients who had taken c ART in a national TCM human immunodeficiency virus treatment trial program(NTCMTP) before 2009 were enrolled in this study and followed for 36 months from November 2009.Patients enrolled in the NTCMTP in 2004 were taken as the first group,those enrolled in 2006 as the second group,and those enrolled in 2009 as the third group.Cumulative survival rates were calculated by the life table method.Survival curves for subgroups were compared by the log-rank test.Hazard ratios were calculated with a Cox proportional hazards model.RESULTS:A total of 1443 AIDS patients were followed for 3 years(4198 person-years).During this period,91(6.3%) patients died and 13(0.9%) were lost to follow-up.The total mortality rate was 2.17/100 person-years.The mortality rate of patients enrolled in the NTCMTP in 2004 was 1.49/100 person-years,which was lower than that of patients enrolled in 2006(2.23/100 person-years) and 2009(3.48/100 person-years).After adjusting for other factors,a shorter time of treatment with TCM,male sex,older age,lower CD4 + T-cell counts,and long-term treatment with c ART were risk factors of mortality.CONCLUSION:Long-term treatment with TCM decreased the mortality risk of AIDS patients.Factors such as being male,older age,CD4+ T-cell counts,and time of treatment with TCM and c ART were correlated with mortality. | Guo Huijun Wang Jian Li Zhengwei Jiang Ziqiang Xu Qianlei Xu Liran | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 9 |
| 16 | In-situ fabricated anisotropic halide perovskite nanocrystals in polyvinylalcohol nanofibers: Shape tuning and polarized emission显示文摘We report an in-situ fabrication of halide perovskite (CH3NH3PbX3,CH3NH3 =methylammonium,MA,X =Cl,Br,I) nanocrystals in polyvinylalcohol (PVA) nanofibers (MAPbX3@PVA nanofibers) through electrospinning a perovskite precursor solution.With the content of the precursors increased,the resulting MAPbBr3 nanocrystals in PVA matrix changed the shape from ellipsoidal to pearl-like,and finely into rods-like.Optimized MAPbBr3@PVA nanofibers show strong polarized emission with the photoluminescence quantum yield of up to 72%.We reveal correlations between the shape of in-situ fabricated perovskite nanocrystals and the polarization degree of their emission by comparing experimental data from the single nanofiber measurements with theoretical calculations.Polarized emission of MAPbBr3@PVA nanofibers can be attributed to the dielectric confinement and quantum confinement effects.Moreover,nanofibers can be efficiently aligned by using parallel positioned conductor strips with an air gap as collector.A polarization ratio of 0.42 was achieved for the films of well-aligned MAPbBr3@PVA nanofibers with a macroscale size of 0.5 cm × 2 cm,which allows potential applications in displays,lasers,waveguides,etc. | Linghai Meng Changgang Yang Jingjia Meng Yongzhi Wang Yong Ge Ziqiang Shao Guofeng Zhang Andrey L.Rogach Haizheng Zhong | 2019 | Nano Research2019，12，6： | 9 |
| 17 | Design and application of a small electrode experimental installation for resistivity measurement of mineral and solid insulating material显示文摘There has not been an effective method to measure the resistivity of small-size sample of mineral and solid insulating material until now.According to the Chinese National Standard(GB/T1410-2006) and features of digital high resistance meter,a small electrode experimental installation was developed;it can work with current high resistance meter;the sample decreases to 18 mm from standard size 100 mm in diameter and reduces by 30.86 times in area.A three-electrode system is supported and precisely positioned by two insulating bases whose diameter is 60 mm and height is 20 mm,which ensures accuracy of device structure and reliability of measuring results.The key technological parameters are as follows:diameter of high voltage electrode is 18mm;diameter of measuring electrode is 14.6 mm;internal diameter and external diameter of guard electrode are 16 and 18 mm,respectively;the gap between guard electrode and measuring electrode is set at 0.6 mm.These parameters are adequate for the measurement of flat specimen of mineral and solid insulating material whose diameter is 18 mm.According to the confirmatory experiment on the volume resistivity and surface resistivity,the measuring results are almost the same,using a small electrode experimental installation and a standard electrode. | WANG Ling LUO Ke LI ZiQiang GUAN SongYun GE Wei ZHANG JunYuan | 2011 | Science China(Technological Sciences)2011，54，4： | 8 |
| 18 | Survival of people living with HIV after treatment with Traditional Chinese Medicine in Henan province of China: a retrospective cohortstudy显示文摘OBJECTIVE: To provide survival estimates of people living with human immunodeficiency virus(PLHIV) after treatment with Traditional Chinese Medicine(TCM) in rural China, to identify the prognostic factors at enrollment, and to explore the effectiveness of TCM intreating PLHIV.METHODS: PLHIV who enrolled in national TCM HIV treatment trial program in October 2004 were analyzed in this study and followed up to October 2010. Survival time was estimated by the Kaplan-Meier curve and hazard ratios, and identifying prognostic factors were computed through Cox proportional hazard models.RESULTS:A total of 1666 PLHIV were included with 102 591 person-months of follow-up. Overall, 312(18.7%) patients died. The total mortality rate over the study period was 3.6 per 100 person-years,which was lower than the worldwide rate. The cumulative survival rate was 95.9% at 1 year[95% confidence interval(CI)(94.8-96.8)] and 80.4% at 6years [95% CI(78.4-82.3)]. Elevated death risks emerged among males, older individuals, and thosewithlowerCD4+T-cellcounts.CONCLUSION: TCM could increase survival and lengthen the life span of PLHIV in Henan province of China, as shown by our retrospective cohort study. Factors such as sex, age, education, and CD4+ T-cell counts correlated to survival. However,retrospective cohorts bias the data, so more prospective studies should be performed to confirm our primary results. | Yantao Jin Zhibin Liu Xiumin Chen Xin Wang Dan Wang Ziqiang Jiang Ying Liu Jian Wang Wen Zou Huijun Guo Liran Xu | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 8 |
| 19 | Bottom water temperature measurements in the South China Sea,eastern Indian Ocean and western Pacific Ocean显示文摘文章报道了一批新的海底底水温度(BWT)数据,其中南海(SCS)158个站位、东印度洋(EIO)30个站位及西太平洋(WPO)37个站位。基于这批新的BWT数据,获得南海和西太平洋海域底水温度与水深经验关系,可为地球物理和物理海洋提供准确、可靠的海底温度边界。这将有助于海底油气资源调查与评估。同时,这批实测数据表明:1)水深超过3500m的海域,其底水温度在南海约为2.47℃,比东印度洋(~1.34℃)和西太平洋(~1.60℃)稍微偏高。这与大洋传送带模式所预测的情况比较吻合。该模式认为:低温高盐的海水,从北大西洋格陵兰岛和冰岛附近海域下沉到深层,然后向南流动,再与南极洲周围海域的低温高盐海水一同向北进入印度洋和太平洋。而南海是一个相对比较封闭的热带边缘海,其内部海水与印度洋和菲律宾海交换有限,导致海水温度整体高于印度洋和太平洋。2)台西南盆地水深在2700~3000m的部分站位,其底水温高达约3.00℃,明显高于其周边同水深海域底水温度(平均值约为2.33℃)。这可能是台西南盆地海底水热活动导致的结果。3)在东印度洋和西太平洋水深超过4800m海域,底水温度随着水压增大稍有升高,其升高率分别为10.6mK·MPa^(-1)和12.0mK·MPa^(-1)。这与理论估算的深层底水绝热压力温度梯度范围较为吻合。这也意味着东印度洋和西太平洋深层底水,主要由绝热自压作用导致其温度随着深度的增大而升高。 | YANG Xiaoqiu SHI Xiaobin ZHAO Junfeng YU Chuanhai GAO Hongfang CHEN Aihua LU Yuanzheng CEN Xianrong LIN Weiren ZENG Xin XU Hehua REN Ziqiang ZHOU Shengqi XU Ziying SUN Jinlong KAMIYA Nana LIN Jian | 2018 | 热带海洋学报2018，37，5： | 8 |
| 20 | Presenilin 2 deficiency facilitates Aβ-induced neuroinflammation and injury by upregulating P2X7 expression显示文摘Accumulating evidence suggests that β-amyloid (Aβ)-induced neuroinflammation plays a prominent and early role in Alzheimer’s disease (AD). In this study, we demonstrated that Presenilin 2 (PS2) deficiency facilitates Aβ-induced neuroinflammation and injury by upregulating P2X7 expression both in vitro and in vivo. PS2 knockout mice demonstrated increased cognitive impairments and cerebral injury. PS2 deficiency increased the expression of P2X7 both in neurons and microglial cells.Furthermore, extracellular ATP also increased in both Aβ-treated and untreated PS2 knockout microglial cells. Notably, Aβ-induced classical proinflammatory cytokines such as IL-1β, IL-1α and TNF-α were increased in PS2 knockout microglial cells, suggesting a potential role for PS2 in the regulation of neuroinflammation. The expression of P2X7 clearly increased in PS2 knockdown BV2 cells. Consistent with in vivo data, Aβ-induced IL-1β production was also clearly enhanced in PS2 knockdown BV2 cells. Additionally, expression of the transcription factor Sp1 was increased in PS2 knockdown cells. When we treated PS2 knockdown cells with the specific Sp1 inhibitor MIT, we observed that enhanced P2X7 expression was significantly rescued. Taken together, these data suggests that PS2 plays a protective role during Aβ-induced neuroinflammation and injury through down-regulation of P2X7 expression. | Juliang Qin Xiaoyu Zhang Ziqiang Wang Jinju Li Zhen Zhang Liangcai Gao Hua Ren Min Qian Bing Du | 2017 | Science China(Life Sciences)2017，60，2： | 7 |
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