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| 1 | Veno occlusive disease: Update on clinical management显示文摘Hepatic veno-occlusive disease is a clinical syndrome characterized by hepatomegaly, ascites, weight gain and jaundice, due to sinusoidal congestion which can be caused by alkaloid ingestion, but the most frequent cause is haematopoietic stem cell transplantation (STC) and is also seen after solid organ transplantation. The incidence of veno occlusive disease (VOD) after STC ranges from 0 to 70%, but is decreasing. Survival is good when VOD is a mild form, but when it is severe and associated with an increase of hepatic venous pressure gradient > 20 mmHg, and mortality is about 90%. Prevention remains the best therapeutic strategy, by using non-myeloablative conditioning regimens before STC. Prophylactic administration of ursodeoxycholic acid, being an antioxidant and antiapoptotic agent, can have some benefit in reducing overall mortality. Defibrotide, which has pro-fibrinolytic and antithrombotic properties, is the most effective therapy; decompression of the sinusoids by a transjugular intrahepatic portosystemic shunt (TIPS) can be tried, especially to treat VOD after liver transplantation and when multiorgan failure (MOF) is not present. Liver transplantation can be the last option, but can not be considered a standard rescue therapy, because usually the concomitant presence of multiorgan failure contraindicates this procedure. | M Senzolo G Germani E Cholongitas P Burra AK Burroughs | 2007 | World Journal of Gastroenterology2007，13，29： | 19 |
| 2 | New insights into the coagulopathy of liver disease and liver transplantation显示文摘The liver is an essential player in the pathway of coagulation in both primary and secondary haemostasis. Only von Willebrand factor is not synthetised by the liver, thus liver failure is associated with impairment of coagulation. However, recently it has been shown that the delicate balance between pro and antithrombotic factors synthetised by the liver might be reset to a lower level in patients with chronic liver disease. Therefore, these patients might not be really anticoagulated in stable condition and bleeding may be caused only when additional factors, such as infections, supervene. Portal hypertension plays an important role in coagulopathy in liver disease, reducing the number of circulating platelets, but platelet function and secretion of thrombopoietin have been also shown to be impaired in patients with liver disease. Vitamin K deficiency may coexist, so that abnormal clotting factors are produced due to lack of gamma carboxylation. Moreover during liver failure, there is a reduced capacity to clear activated haemostatic proteins and protein inhibitor complexes from the circulation. Usually therapy for coagulation disorders in liver disease is needed only during bleeding or before invasive procedures. When end stage liver disease occurs, liver transplantation is the only treatment available, which can restore normal haemostasis, and correct genetic clotting defects, such as haemophilia or factor V Leiden mutation. During liver transplantation haemorrage may occur due to the pre-existing hypocoagulable state, the collateral circulation caused by portal hypertension and increased fibrinolysis which occurs during this surgery. | M Senzolo P Burra E Cholongitas AK Burroughs | 2006 | World Journal of Gastroenterology2006，12，48： | 12 |
| 3 | Child-Pugh-Turcott versus Meld score for predicting survival in a retrospective cohort of black African cirrhotic patients显示文摘AIM: To compare the performance of the Child-Pugh-Turcott (CPT) score to that of the model for end-stage liver disease (MELD) score in predicting survival of a retrospective cohort of 172 Black African patients with cirrhosis on a short and mid-term basis.METHODS: Univariate and multivariate (Cox model) analyses were used to identify factors related to mortality. Relationship between the two scores was appreciated by calculating the correlation coefficient. The Kaplan Meier method and the log rank test were used to elaborate and compare survival respectively. The Areas Under the Curves were used to compare the performance between scores at 3, 6 and 12 mo.RESULTS: The study population comprised 172 patients, of which 68.9% were male. The mean age of the patient was 47.5 ± 13 years. Hepatitis B virus infection was the cause of cirrhosis in 70% of the cases. The overall mortality was 31.4% over 11 years of follow up. Independent factors significantly associated with mortality were: CPT score (HR = 3.3, 95% CI [1.7-6.2]) (P < 0.001) (stage C vs stage A-B); Serum creatine (HR = 2.5, 95% CI [1.4-4.3]) (P = 0.001) (Serum creatine > 1.5 mg/dL versus serum creatine < 1.5 mg/dL); MELD score (HR = 2.9, 95% CI [1.63-5.21]) (P < 0.001) (MELD > 21 vs MELD < 21). The area under the curves (AUC) that predict survival was 0.72 and 0.75 at 3 mo (P = 0.68), 0.64 and 0.62 at 6 mo (P = 0.67), 0.69 and 0.64 at 12 mo (P = 0.38) respectively for the CPT score and the MELD score.CONCLUSION: The CPT score displays the sameprognostic significance as does the MELD score in black African patients with cirrhosis. Moreover, its handling appears less cumbersome in clinical practice as compared to the latter. | KA Attia KC Ackoundou-N'guessan AT N’dri-yoman AK Mahassadi E Messou YF Bathaix YH Kissi | 2008 | World Journal of Gastroenterology2008，14，2： | 5 |
| 4 | 妊娠并发症及妊娠特点与未来血压升高风险的关系显示文摘妊娠特点与心血管病风险相关,但其与高血压或血压水平的独立关联仍不明确。该研究将瑞典医学出生登记与Vsterbotten(瑞典北部)干预研究数据相联系。纳入妊娠前无高血压的40岁经产女性15 896人,用线性回归和Logistic回归分析以前妊娠因素与血压水平及高血压的关系。妊娠因素包括胎次、首次分娩年龄、子痫前期、妊娠期糖尿病、胎盘早剥、小于胎龄儿(出生体质量〈相同胎龄儿第3百分位)或死胎。 | Parikh NI Norberg M Ingelsson E Cnattingius S Vasan RS Domellf M Jansson JH Edstedt Bonamy AK 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，2： | 3 |
| 5 | 高度近视伴色觉缺失的家系分析(英文)显示文摘目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础。 | Nimet nay Gündogan Ay■e Gül Koak Altinta■ Nezih Durmazlar Koray Gümüs Zerrin Yilmaz Kemal Ksemehmetoglu | 2007 | 国际眼科杂志2007，7，3： | 2 |
| 6 | Primary culture of human retinal glia显示文摘 | Aotaki-keen AE Harvey AK de Juan E | 1991 | Invest Ophthalmol Vis Sic1991，32，6： | 2 |
| 7 | Gastrin-histamine sequence in the regulation of gastric acid secretion显示文摘 | Waldum HI Sandvik AK Brenna E | 1991 | Gut1991，32，6： | 1 |
| 8 | Androgen influence on lacrimal gland apoptosis, necrosis, and lymphocytic infiltration 显示文摘 | AzzaroLo AM Wood RL Mircheff AK Richters A Olsen E | 1999 | Invest Ophthalmol Vis Sci1999，40，3： | 1 |
| 9 | Complications in post-mastectomy breast reconstruction: two year results of the Michigan breast reconstruction outcome study 显示文摘 | Alderman AK Wilkins E Kim M | 2002 | Plast Reconstr Surg2002，109，7： | 1 |
| 10 | A new technique for abdominal heart transplantation in rats显示文摘 | Demirsoy E Arbatli H Korkut AK | 2003 | J Cardiovasc Surg2003，44，6： | 1 |
| 11 | Vascular endothelial growth factor inhibitors: investigational therapies for the treatment ofpsoriasis显示文摘 | Weidemann AK Crawshaw AA Byrne E | 2013 | Clin Cosmet Investig Dermatol2013，6，： | 1 |
| 12 | CYP2E1 polymorphism,cigarette smoking,p53 expression,and survival in non-small cell lung cancer: a long term follow-up study显示文摘 | Haque AK Au W Ca j a s -Sa l a z a r N e t al | 2004 | Appl Immunohistochem Mol Morphol2004，12，4： | 1 |
| 13 | Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families 显示文摘 | Villano MJ Huber AK Greenberg DA Golden BK Concepcion E Tomer Y | 2009 | J Clin Endocrinol Metab2009，94，4： | 1 |
| 14 | Quality improvements in the preanalyticalphase:focus on urine specimen workflow显示文摘 | Stankovic AK DeLauro E | 2008 | Clin Lab Med2008，28，2： | 1 |
| 15 | Colitis in transgenic and knockout animals as models of human inflammatory bowel disease显示文摘 | Bhan AK Mizoguchi E Smith RN | 1999 | Immunol Rev1999，169，： | 1 |
| 16 | Incased anxiety level and high salivary and serum stomatitis 显示文摘 | Albanidou-Farmaki E Poulopoulos AK Epivatianos A | 2008 | Tohoku Scully C Hodgson likeulcers in periodic Pathol Oral Radiol in patients with recurrent aphthous J Exp Med2008，214，4： | 1 |
| 17 | Impact of breast cancer surgery on the self-esteem and sexual life of female patients 显示文摘 | Markopoulos C Tsaroucha AK Kouskos E | 2009 | J Int Med Res2009，37，1： | 1 |
| 18 | Non-invasive tests for liver fibrosis:encouraging or discouraging results显示文摘 | Burroughs AK Cholongitas E | 2007 | J Hepatol2007，46，5： | 1 |
| 19 | Colitis in transgenic and knockout animal as model of human inflammatory bowel disease显示文摘 | Bhan AK Mizoguchi E Smith RN | 1999 | Immunol Rev1999，169，： | 1 |
| 20 | Role of tumor necrosis factor-alpha in acute pancreatitis:from biological basis to clinical evidence显示文摘 | Malleo G Mazzon E Siriwardena AK | 2007 | Shock2007，28，2： | 1 |
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