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| 1 | Predictive factors for anastomotic leakage after laparoscopic colorectal surgery显示文摘Every colorectal surgeon during his or her career is faced with anastomotic leakage(AL); one of the most dreaded complications following any type of gastrointestinal anastomosis due to increased risk of morbidity, mortality, overall impact on functional and oncologic outcome and drainage on hospital resources. In order to understand and give an overview of the AL risk factors in laparoscopic colorectal surgery, we carried out a careful review of the existing literature on this topic and found several different definitions of AL which leads us to believe that the lack of a consensual, standard definition can partly explain the considerable variations in reported rates of AL in clinical studies. Colorectal leak rates have been found to vary depending on the anatomic location of the anastomosis with reported incidence rates ranging from 0 to 20%, while the laparoscopic approach to colorectal resections has not yet been associated with a significant reduction in AL incidence. As well, numerous risk factors, though identified, lack unanimous recognition amongst researchers. For example, the majority of papers describe the risk factors for left-sided anastomosis, the principal risk being male sex and lower anastomosis, while little data exists defining AL risk factors in a right colectomy. Also, gut microbioma is gaining an emerging role as potential risk factor for leakage. | Antonio Sciuto Giovanni Merola Giovanni D De Palma Maurizio Sodo Felice Pirozzi Umberto M Bracale Umberto Bracale | 2018 | World Journal of Gastroenterology2018，24，21： | 48 |
| 2 | Neoadjuvant-intensified treatment for rectal cancer:Time to change?显示文摘AIM:To investigate whether neoadjuvant-intensified radiochemotherapy improved overall and disease-free survival in patients with locally advanced rectal cancer.METHODS:Between January 2007 and December 2011,80 patients with histologically confirmed rectal adenocarcinoma were enrolled.Tumors were clinically classified as either T3 or T4 and by the N stage based on the presence or absence of positive regional lymph nodes.Patients received intensified combined modality treatment,consisting of neoadjuvant radiation therapy(50.4-54.0 Gy) and infusional chemotherapy(oxaliplatin 50 mg/m 2) on the first day of each week,plus five daily continuous infusions of fluorouracil(200 mg/m 2 per die) from the first day of radiation therapy until radiotherapy completion.Patients received five or six cycles of oxaliplatin based on performance status,clinical lymph node involvement,and potential risk of a non-sphincter-conserving surgical procedure.Surgery was planned 7 to 9 wk after the end of radiochemotherapy treatment;adjuvant chemotherapy treatment was left to the oncologist's discretion and was recommended in patients with positive lymph nodes.After treatment,all patients were monitored every three months for the first year and every six months for the subsequent years.RESULTS:Of the 80 patients enrolled,75 patients completed the programmed neoadjuvant radiochemotherapy treatment.All patients received the radiotherapy prescribed total dose;five patients suspended chemotherapy indefinitely because of chemotherapyrelated toxicity.At least five cycles of oxaliplatin were administered to 73 patients.Treatment was well tolerated with high compliance and a good level of toxicity.Most of the acute toxic effects observed were classified as grades 1-2.Proctitis grade 2 was the most common symptom(63.75%) and the earliest manifestation of acute toxicity.Acute toxicity grades 3-4 was reported in 30% of patients and grade 3 or 4 diarrhoea reported in just three patients(3.75%).Seventy-seven patients underwent surgery;low anterior resection was performed in 52 patients,Miles' surgery in 11 patients and total mesorectal excision in nine patients.Fifty patients showed tumor downsizing ≥ 50% pathological downstaging in 88.00% of tumors.Out of 75 patients surviving surgery,67 patients(89.33%) had some form of downstaging after preoperative treatment.A pathological complete response was achieved in 23.75% of patients and a nearly pathologic complete response(stage ypT1ypN0) in six patients.An involvement of the radial margin was never present.During surgery,intra-abdominal metastases were found in only one patient(1.25%).Initially,45 patients required an abdominoperineal resection due to a tumor distal margin ≤ 5 cm from the anal verge.Of these patients,only seven of them underwent Miles' surgery and sphincter preservation was guaranteed in 84.50% of patients in this subgroup.Fourteen patients received postoperative chemotherapy.In the full analysis of enrolled cohort,eight of the 80 patients died,with seven deaths related to rectal cancer and one to unrelated causes.Local recurrences were observed in seven patients(8.75%) and distant metastases in 17 cases(21.25%).The fiveyear rate of overall survival rate was 90.91%.Using a median follow-up time of 28.5 mo,the cumulative incidence of local recurrences was 8.75%,and the overall survival and disease-free survival rates were 90.00% and 70.00%,respectively.CONCLUSION:The results of this study suggest oxaliplatin chemotherapy has a beneficial effect on overall survival,likely due to an increase in local tumor control. | Daniela Musio Francesca De Felice Nadia Bulzonetti Roberta Guarnaccia Rossella Caiazzo Caterina Bangrazi Nicola Raffetto Vincenzo Tombolini | 2013 | World Journal of Gastroenterology2013，19，20： | 5 |
| 3 | Neoadjuvant chemoradiotherapy for locally advanced rectal cancer:The debate continues显示文摘Rectal carcinoma represents the 30% of all colorectal cancers, with about 40000 new cases/years. In the past two decades, the management of rectal cancer has made important progress, highlighting the main role of a multimodality strategy approach, combining surgery, radiation therapy and chemotherapy. Nowadays, surgery remains the primary treatment and neoadjuvant chemoradiotherapy, based on fluoropyrimidine(5-FU) continuous infusion, is considered the standard in locally advanced rectal carcinoma. The aim is to reduce the incidence of local recurrence and to perform a conservative surgery. To improve these purposes different drugs combination have been tested in the neo-adjuvant setting. At American Society of Clinical Oncology 2014 an important abstract was presented focusing on the role of adding oxaliplatin to concomitant treatment, in patients with locally advanced rectal carcinoma. Rodel et al reported on the CAO/ARO/AIO-04 randomized phase Ⅲ trial that compared standard treatment with 5-FU and radiation therapy, to oxaliplatin plus 5-FU inassociation with radiation therapy. The addition of oxaliplatin to the neo-adjuvant treatment has been shown to improve disease-free survival from 71.2% to 75.9%(P = 0.03). This editorial was planned to clarify the optimal treatment in patients with locally advanced rectal cancer, considering the results from CAO/ARO/AIO-04 study. | Francesca De Felice Daniela Musio Luciano Izzo Vincenzo Tombolini | 2014 | World Journal of Gastrointestinal Oncology2014，6，12： | 5 |
| 4 | An unusual case of fatty liver in a patient with desmoid tumor显示文摘A desmoid tumor,also known as aggressive fibromatosis,is a rare benign neoplasm that arises from fascial or musculoaponeurotic tissues.It can occur in any anatomical location,most commonly the abdominal wall,shoulder girdle and retroperitoneum.The typical clinical presentation is a painless mass with a slow and progressive invasion of contiguous structures.It is associated with a high local recurrence rate after resection.Many issues regarding the optimal treatment of desmoid tumors remain controversial.Aggressive surgical resection with a wide margin(2-3 cm) remains the gold standard treatment with regard to preserving quality of life.Radiotherapy alone has been shown to be effective for the control of unresectable or recurrent lesions.Desmoid tumors tend to be locally infiltrative,therefore,the fields must be generous to prevent marginal recurrence.The radiation dose appropriate for treating desmoid tumors remains controversial.We present a 25-year-old Caucasian man with local recurrence of a desmoid tumor after repeated surgical resection,treated with radiotherapy.The patient achieved complete tumor regression at 4 mo after radiotherapy,and he is clinically free of disease at 12 mo after the end of treatment,with an acceptable quality of life.The patient developed short bowel syndrome as a complication of second surgical resection.Consequently,radiotherapy might have worsened an already present malabsorption and so led to steatohepatitis. | Francesca De Felice Daniela Musio Rossella Caiazzo Bartolomeo Dipalma Lavinia Grapulin Camilla Proietti Semproni Vincenzo Tombolini | 2012 | World Journal of Gastroenterology2012，18，24： | 2 |
| 5 | Prevalence and natural history of hepatitis B and C infections in a large population of IBD patients treated with anti-tumor necrosis factor-α agents显示文摘 | Alfredo Papa Carla Felice Manuela Marzo Gianluca Andrisani Alessandro Armuzzi Marcello Covino Giammarco Mocci Daniela Pugliese Italo De Vitis Antonio Gasbarrini Gian Lodovico Rapaccini Luisa Guidi | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 6 | Newborn hearing screening by transient evoked otoacoustic emissions: analysis of response as a function of risk factors 显示文摘 | DE CAPUA B DE FELICE C COSTANTINI D | 2003 | Acta Otorhinolaryngol Ital2003，23，： | 1 |
| 7 | Persistent pulmonary hypertension of the newborn: therapeutical approach 显示文摘 | Latini G Del Vecchio A De Felice C | 2008 | Mini Rev Med Chem2008，8，14： | 1 |
| 8 | In utero exposure to di2 (22ethylhexyl) phthalate and duration of human pregnancy显示文摘 | Latini G De Felice C Presta G | 2003 | Environ Health Perspect2003，111，： | 1 |
| 9 | Abeta oligo- mers induce neuronal oxidative stress through an N-methyl-D-aspar- tate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine 显示文摘 | DE FELICE F G VELASCO P T LAMBERT M P | 2007 | J Biol Chem2007，282，11： | 1 |
| 10 | Minimal and bronchopul-monary dysplasia in extremely low bithweight infants显示文摘 | Latini G De Felice C Presta G | 2003 | Eur J Paediatr2003，162，4： | 1 |
| 11 | Clinical outcome of patients with chronic total occlusion treated with drug-eluting stents显示文摘 | De Felice F Fiorilli R Parma A | 2009 | Int J Cardiol2009，132，3： | 1 |
| 12 | In utero exposure to di-(2-ethylhexyl) phthalate and uration of human preg- nancy 显示文摘 | Latini G De Felice C Presta G | 2003 | Environ Heahh Perspect2003，111，14： | 1 |
| 13 | In utero exposure to di-(2-ethylhexyl) phthalate and duration of human pregnancy 显示文摘 | LATINI G DE FELICE C PRESTA G | 2003 | Environ Health Perspect2003，111，： | 1 |
| 14 | The pulse oximeterperfu-sion index as a predictor for high illness severityinneonates 显示文摘 | De Felice C Latini G Vacca P | 2002 | Eur J Pediatric Med2002，161，6： | 1 |
| 15 | Alzheimer's disease- type neuronal tau hyperphosphorylation induced by A beta oli- gomers 显示文摘 | De Felice F G Wu D l ambert M P | 2008 | Neurobiol Aging2008，29，9： | 1 |
| 16 | The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain显示文摘 | Lazzaro D Price M de Felice M | 1991 | Development1991，113，： | 1 |
| 17 | Plasticizer infant nutrition and reproductive health 显示文摘 | Giuseppe Latini Claudio De Felice Alberto Verrotti | 2004 | Reproductive Toxicology2004，19，1： | 1 |
| 18 | Thyroid development and its disorders:genetics and molecular mechanisms显示文摘 | DE FELICE M DI LAURO R | 2004 | Endocr Rev2004，25，： | 1 |
| 19 | Engagement ofdescending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain显示文摘 | De Felice M Sanoja R Wang R.Z Vera-Portocarrero L Oyarzo J King T | | 0，，： | 1 |
| 20 | Triptan-induced latent sensitization: A possible basis for medication overuse headache显示文摘 | De Felice M Ossipov MH Wang R | 2010 | Ann Nenrol2010，67，3： | 1 |
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