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| 1 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 2 | Cylindrical GaAs quantum wires incorporated within chrysotile asbestos nanotubes : Fabrication and polarized optical absorption spectra显示文摘 | Poborchii V V Ivanova M S Salamatina I A | 1994 | Superlattices and Microstructures1994，16，2： | 1 |
| 3 | Vagus nerve stimulationattenuates the systemic inflammatory responses to endotoxin显示文摘 | Borovikova LV Ivanova S Zhang M | 2000 | Nature2000，405，6785： | 1 |
| 4 | Formation and Investigation of Sol-Gel TiO2-V2O5 System 显示文摘 | Ivanova T Harizanova A Surtchev M | 2002 | Materials Letters2002，55，5： | 1 |
| 5 | Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin 显示文摘 | Borovikova LV Ivanova S Zhang M | 2000 | Nature2000，405，6785： | 1 |
| 6 | Vagus nerve stimula- tion attenuates the systemic inflammatory response to endotoxin 显示文摘 | Borovikova LV Ivanova S Zhang M | 2000 | Nature2000，405，： | 1 |
| 7 | Transesterification of rapeseed oil under fiow conditions catalyzed by basic solids: M - AI(La) -O (M =Sr, Ba), M-Mg-O (M=Y, La) 显示文摘 | SHERSTYUK O V IVANOVA A S LEBEDEV M Y | 2012 | Appl Catal A- Gen2012，，： | 1 |
| 8 | 显示文摘 | Blagodatskikh I V Vasil'eva O V Ivanova E M | 2004 | Polymer2004，45，： | 1 |
| 9 | Minimally invasive surgery of patients with hypertensive intracerebral bleedings显示文摘 | Agmazov M K Bersnev V P Ivanova N E | 2009 | Vestn Khir Im Ⅱ Grek2009，168，2： | 1 |
| 10 | The efficacy of a sub- hypnotic dose of propofol in preventing laryngospasm fol- lowing tonsillectomy and adenoidectomy in children显示文摘 | Batra YK Ivanova M Ali SS | 2005 | Pe- diatr Anesth2005，15，12： | 1 |
| 11 | Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin显示文摘 | Borovikova LV Ivanova S Zhang M | 2000 | Nature2000，405，6785： | 1 |
| 12 | Ribosome rescue by tmRNA requires truncated mRNAs显示文摘 | Ivanova N Pavlov M Y Felden B | 2004 | J Mol Biol2004，338，1： | 1 |
| 13 | Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin显示文摘 | Borovikova L V Ivanova S Zhang M | 2000 | Nature2000，405，： | 1 |
| 14 | Fibroblast growth factor receptors in breast cancer: expression, downstream effects, and possible drug targets显示文摘 | Tenhagen M van Diest PJ Ivanova IA | 2012 | En docrine Relate Cancer2012，19，4： | 1 |
| 15 | Initialization of Neural Networks by Means of Decision Trees显示文摘 | I Ivanova M Kubat | 1995 | Knowledge-Based Systems1995，，： | 1 |
| 16 | Chromatographic Methods for the Isolation of,and Refolding of Proteins from Escherichia coli Inclusion Bodies显示文摘 | Gu Z Weidenhaupt M Ivanova N | 2002 | Protein Expr Purif2002，25，1： | 1 |
| 17 | On the structural phase transformations in GexSb40-x Se60 glasses显示文摘 | IVANOVA Z G PAMUKCHIEVA V VLCEK M | 2001 | J Non-Cryst Solids2001，，： | 1 |
| 18 | Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin显示文摘 | Borovikova LV Ivanova S Zhang M | 2000 | Nature2000，405，6785： | 1 |
| 19 | Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin显示文摘 | Borovikova LV Ivanova S Zhang M | 2000 | Nature2000，405，6785： | 1 |
| 20 | Application of the detrended fluctuation analysis (DFA) method for describing cloud breaking显示文摘 | IVANOVA K AUSLOOS M | 1999 | Physica A1999，274，12： | 1 |
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