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| 1 | Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications显示文摘Atherosclerosis manifests itself clinically at advanced stages when plaques undergo hemorrhage and/or rupture with superimposed thrombosis, thus abruptly stopping blood supply. Identification of markers of plaque destabilization at a pre-clinical stage is, therefore, a major goal of cardiovascular research. Promising results along this line were provided by studies investigating the lipoprotein-associated phospholipase A2(Lp-PLA2), a member of phospholipase A2 proteins family that plays a key role in the metabolism of pro-inflammatory phospholipids, as oxidized low-density lipoproteins, and in the generation of pro-atherogenic metabolites, including lysophosphatidylcholine and oxidized free fatty acids. We herein review the experimental and clinical studies supporting use of Lp-PLA2 activity for predicting cardiovascular events. To his end we considered not only Lp-PLA2 activity and mass, but also Lp-PLA2 gene variations and their association with incident coronary artery disease, stroke, and cardiovascular mortality. Based on these evidences the major scientific societies have included in their guidelines the measurement of Lp-PLA2 activity among the biomarkers that are useful in risk stratification of adult asymptomatic patients at intermediate cardiovascular risk. The results of two recently published major clinical trials with the LpPLA2 inhibitor darapladib, which seem to challenge the pathogenic role of Lp-PLA2, will also be discussed. | Giuseppe Maiolino Valeria Bisogni Giacomo Rossitto Gian Paolo Rossi | 2015 | World Journal of Cardiology2015，7，10： | 66 |
| 2 | 急性心肌梗死患者脂蛋白相关磷脂酶A2水平与冠脉病变的相关性分析显示文摘目的分析急性心肌梗死(AMI)患者脂蛋白相关磷脂酶A2(Lp-PLA2)水平与冠脉病变程度的相关性。方法选取2014年1月-2015年1月该院收治的AMI且行冠脉造影患者74例为AMI组,同期行冠脉造影或冠脉CTA除外冠心病的患者61例为对照组,使用酶联免疫吸附法(ELISA)检测患者Lp-PLA2水平。根据冠脉损害严重程度用Gensini评分方法进行评分,再以冠脉病变支数、Gensini积分将AMI患者分成不同的亚组,用统计学方法比较各组Lp-PLA2水平的不同。结果 AMI组患者血浆Lp-PLA2水平较对照组高,但差异无统计学意义(P>0.05)。Lp-PLA2水平与冠脉病变支数有明显相关性(P<0.05),且与冠脉Gensini积分呈正相关(r=0.713,P<0.01)。结论AMI患者Lp-PLA2水平与冠脉病变弥漫程度无明显关系,但可在一定程度上反映冠脉管腔狭窄程度。 | 李琳 李琦 赵培勇 | 2016 | 临床合理用药杂志2016，9，4： | 5 |
| 3 | 脂蛋白相关磷脂酶A_2与缺血性脑卒中的研究进展显示文摘动脉粥样硬化是缺血性脑卒中的主要病因,脂蛋白相关磷脂酶A2(Lp-PLA2)作为新型炎症标志物参与动脉粥样硬化形成,并与斑块易损性相关。目前研究认为Lp-PLA2在评估动脉粥样硬化性缺血性脑卒中的危险分层及复发风险中有重要作用,将成为动脉粥样硬化性缺血性脑卒中的独立预测因子。本文从Lp-PLA2的生物学特征、在AS中的双重作用及其与颈动脉粥样硬化、缺血性脑卒中的相关性等方面进行综述。 | 徐邦娴 邓远飞 | 2015 | 中国现代医生2015，53，14： | 3 |
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