|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intestinal microbiota in pathophysiology and management of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS) is a functional bowel disorder without any structural or metabolic abnormalities that sufficiently explain the symptoms, which include abdominal pain and discomfort, and bowel habit changes such as diarrhea and constipation. Its pathogenesis is multifactorial: visceral hypersensitivity, dysmotility, psychosocial factors, genetic or environmental factors, dysregulation of the brain-gut axis, and altered intestinal microbiota have all been proposed as possible causes. The human intestinal microbiota are composed of more than 1000 different bacterial species and 1014 cells, and are essential for the development, function, and homeostasis of the intestine, and for individual health. The putative mechanisms that explain the role of microbiota in the development of IBS include altered composition or metabolic activity of the microbiota, mucosal immune activation and inflammation, increased intestinal permeability and impaired mucosal barrier function, sensory-motor disturbances provoked by the microbiota, and a disturbed gut-microbiota-brain axis. Therefore, modulation of the intestinal microbiota through dietary changes, and use of antibiotics, probiotics, and anti-inflammatory agents has been suggested as strategies for managing IBS symptoms. This review summarizes and discusses the accumulating evidence that intestinal microbiota play a role in the pathophysiology and management of IBS. | Kang Nyeong Lee Oh Young Lee | 2014 | World Journal of Gastroenterology2014，20，27： | 35 |
| 2 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 3 | Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome显示文摘AIM:To investigate the correlations between selfreported symptoms of irritable bowel syndrome(IBS) and the gastrointestinal(GI) microbiota composition.METHODS:Fecal samples were collected from a total of 44 subjects diagnosed with IBS.Their symptoms were monitored with a validated inflammatory bowel disease questionnaire adjusted for IBS patients.Thirteen quantitative real-time polymerase chain reaction assays were applied to evaluate the GI microbiota composition.Eubacteria and GI bacterial genera(Bifidobacterium,Lactobacillus and Veillonella),groups(Clostridium coccoides/Eubacterium rectale,Desulfovibrio desulfuricans) and distinct bacterial phylotypes [closest 16S rDNA sequence resemblance to species Bifidobacterium catenulatum,Clostridium cocleatum,Collinsella aerofaciens(C.aerofaciens),Coprococcus eutactus(C.eutactus),Ruminococcus torques and Streptococcus bovis ] with a suspected association with IBS were quantified.Correlations between quantities or presence/absence data of selected bacterial groups or phylotypes and various IBSrelated symptoms were investigated.RESULTS:Associations were observed between subjects' self-reported symptoms and the presence or quantities of certain GI bacteria.A Ruminococcus torques(R.torques)-like(94% similarity in 16S rRNA gene sequence) phylotype was associated with severity of bowel symptoms.Furthermore,among IBS subjects with R.torques 94% detected,the amounts of C.cocleatum 88%,C.aerofaciens-like and C.eutactus 97% phylotypes were significantly reduced.Interesting observations were also made concerning the effect of a subject's weight on GI microbiota with regard to C.aerofaciens like phylotype,Bifidobacterium spp.and Lactobacillus spp.CONCLUSION:Bacteria seemingly affecting the symptom scores are unlikely to be the underlying cause or cure of IBS,but they may serve as biomarkers of the condition. | Erja Malinen Lotta Krogius-Kurikka Janne Nikkil Airi Palva Anna Lyra Anne Jskelinen Teemu Rinttil Terttu Vilpponen-Salmela Atte Johannes von Wright | 2010 | World Journal of Gastroenterology2010，16，36： | 13 |
| 4 | 2型糖尿病肠道菌群研究进展显示文摘2型糖尿病是一种常见的慢性消耗性疾病,其发病机制十分复杂,流行病学研究表明,肥胖、高热量饮食、体力活动不足及年龄增大是2型糖尿病最主要的环境因素。它是一种以胰岛素抵抗和胰岛素分泌不足为特征的代谢性疾病。肠道菌群作为进入人体的一个重要环境因素,肠道微生物的菌群变化影响宿主能量物质的吸收,调节肠道的分泌功能和非特异性免疫功能,从营养、代谢、疾病等各方面与我们生命活动相关。肠道菌群已成为我们身体的一部分,影响宿主的免疫,在肥胖、糖尿病、代谢综合征等疾病中都具有非常重要的作用。 | 马巧灵 张发 刘朝芹 王廷江 | 2018 | 中国微生态学杂志2018，30，11： | 12 |
| 5 | 16SrRNA实时荧光定量PCR检测肠道菌群的研究显示文摘目的:应用细菌的16SrRNA序列设计双歧杆菌(Bifidobacterium)、乳酸杆菌(Lactobacillus)、大肠杆菌(E.coli)、肠球菌(Enterococcus)的引物并对肠道的这4种细菌菌属进行定量测定,绕过分离培养环节,以微生物rRNA/rDNA基因作为种属鉴别序列,确定肠道菌群的情况。方法:采用腹腔注射链脲菌素(STZ)的方法建立小鼠糖尿病模型,分别检测小鼠肠道主要的菌群。结果:造模成功小鼠血糖升高(>12.3mmol/L,P<0.05)时,肠道益生菌(双歧杆菌,乳酸杆菌)数量降低(P<0.05),而大肠杆菌、肠球菌数量增加(P<0.05)。结论:小鼠糖尿病模型可引起肠道菌群失调,荧光定量PCR是一种特异性高、敏感性强的定量方法,可正确定量肠道中的细菌菌群数量。 | 张小贤 钱香 楼正青 陈莹莹 沈岳良 | 2010 | 中国高等医学教育2010，，6： | 11 |
| 6 | 肠道微生态变化及临床应用显示文摘近年来,随着基因组学、蛋白组学、代谢组学及分子生物学技术的进展,人类对人体微生态系统的认识步入了新境界。据估计,肠道微生态大约有15 000-36 000个菌种^[1],几乎参与了所有与肠道有关的人体生理功能。Ley等^[2]证实,肠道微生态改变与肥胖密切相关;O’Hara等[3]认为,肠道微生态是一个代谢器官;Cani等^[4]进一步提出了肠道微 生态系统作为潜在药物治疗靶点的可能性。 | 秦环龙 梁勇 | 2011 | 中国普外基础与临床杂志2011，18，12： | 11 |
| 7 | 肠道微生态与肠息肉发生的相关性探讨显示文摘肠道微生态作为机体最重要的微生态系统,与糖尿病、肥胖症、肿瘤、肠易激综合征等疾病密切相关,但肠息肉的发生与肠道微生态的相关性研究较少。我们通过对年龄、饮食、肥胖等因素的分析,揭示肠道微生态与肠息肉发生的相关性,冀望有助于提高肠息肉的早期诊断率,降低肠癌的发生率。 | 李旭颖 孙涛 | 2015 | 生物技术通讯2015，26，2： | 11 |
| 8 | Methodological issues in the study of intestinal microbiota in irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS) is an intestinal functional disorder with the highest prevalence in the industrialized world. The intestinal microbiota(IM) plays a role in the pathogenesis of IBS and is not merely a consequence of this disorder. Previous research efforts have not revealed unequivocal microbiological signatures of IBS, and the experimental results are contradictory. The experimental methodologies adopted to investigate the complex intestinal ecosystem drastically impact the quality and significance of the results. Therefore, to consider the methodological aspects of the research on IM in IBS, we reviewed 29 relevant original research articles identified through a PubMed search using three combinations of keywords: 'irritable bowel syndrome + microflora', 'irritable bowel syndrome + microbiota' and 'irritable bowel syndrome + microbiome'. For each study, we reviewed the quality and significance of the scientific evidence obtained with respect to the experimental method adopted. The data obtained from each study were compared with all considered publications to identify potential inconsistencies and explain contradictory results. The analytical revision of the studies referenced in the present review has contributed to the identification of microbial groups whose relative abundance significantly alters IBS, suggesting that these microbial groups could be IM signatures for this syndrome. The identification of microbial biomarkers in the IM can be advantageous for the development of new diagnostic tools and novel therapeutic strategies for the treatment of different subtypes of IBS. | Valentina Taverniti Simone Guglielmetti | 2014 | World Journal of Gastroenterology2014，20，27： | 10 |
| 9 | 氟哌噻吨美利曲辛联合布拉酵母菌治疗腹泻型肠易激综合征患者焦虑抑郁症状疗效的研究显示文摘目的观察对肠易激综合征(irritable bowel syndrome,IBS)并伴有焦虑抑郁状态的患者用氟哌噻吨美利曲辛联合布拉酵母菌进行治疗的疗效。方法选择于2013年1月至2015年1月在湖北医学院附属东风公司总医院住院治疗的伴有焦虑抑郁症状的腹泻型IBS患者120例为研究对象,本次研究采取多中心、随机、前瞻性的研究方法,将这120例患者分为联合治疗组(60例)和对照组(60例),联合治疗组用氟哌噻吨美利曲辛加口服布拉酵母菌,对照组仅口服布拉酵母菌,疗程为4周。分别在治疗前、治疗1周后、治疗4周后对胃肠道症状和情绪障碍进行评估,同时观察2组患者的不良症状。统计学分析采用卡方检验。结果治疗1周后,对照组和联合治疗组患者的胃肠道症状改善有效率分别为23.3%(14/60)和31.7%(19/60),差异无统计学意义(P>0.05),汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分改善的有效率分别为11.8%(6/51)和33.3%(19/57),汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分中症状改善的有效率分别为16.1%(9/56)和35.6%(21/59),差异均具有统计学意义(P<0.05)。治疗4周后,联合治疗组和对照组的胃肠道症状改善有效率分别为93.0%(53/57)和74.1%(43/58),HAMD评分改善的有效率分别为64.8%(35/54)和34.7%(17/49);HAMA评分中症状改善的有效率分别为80.4%(45/56)和35.2%(19/54),差异均具有统计学意义(χ~2=5.679,P=0.017;χ~2=23.056,P<0.01)。治疗1周后,联合治疗组和对照组患者的不良症状发生率都为5.0%(3/60),治疗4周后,联合治疗组和对照组患者的不良症状发生率分别为3.5%(2/57)和3.4%(2/58)。2组不良症状发生率差异均不具有统计学意义(均P>0.05)。结论氟哌噻吨美利曲辛与布拉酵母菌联合治疗不仅可有效改善腹泻型IBS患者的焦虑抑郁症状,同时能够有效改善患者的消化道症状,其治疗效果明显优于单用布拉酵母菌进行治疗。 | 王丹 张丽莉 | 2018 | 海军医学杂志2018，39，1： | 9 |
| 10 | Upper gastrointestinal microbiota and digestive diseases显示文摘Metagenomics which combines the power of genomics,bioinformatics,and systems biology,provide new access to the microbial world.Metagenomics permit the genetic analysis of complex microbial populations without requiring prior cultivation.Through the conceptual innovations in metagenomics and the improvements in DNA high-throughput sequencing and bioinformatics analysis technology,gastrointestinal microbiology has entered the metagenomics era and become a hot topic worldwide.Human microbiome research is underway,however,most studies in this area have focused on the composition and function of the intestinal microbiota and the relationship between intestinal microbiota and metabolic diseases(obesity,diabetes,metabolic syndrome,etc.) and intestinal disorders [inflammatory bowel disease,colorectal cancer,irritable bowel syndrome(IBS),etc.].Few investigations on microbiota have been conducted within the upper gastrointestinal tract(esophagus,stomach and duodenum).The upper gastrointestinal microbiota is essential for several gastrointestinal illnesses,including esophagitis,Barrett's esophagus,and esophageal carcinoma,gastritis and gastric cancer,small intestinal bacterial overgrowth,IBS and celiac disease.However,the constitution and diversity of the microbiota in different sections of the upper gastrointestinal tract under health and various disease states,as well as the function of microbiota in the pathogenesis of various digestive diseases are still undefined.The current article provides an overview of the recent findings regarding the relationship between upper gastrointestinal microbiota and gastrointestinal diseases;and discusses the study limitations and future directions of upper gastrointestinal microbiota research. | Zi-Kai Wang Yun-Sheng Yang | 2013 | World Journal of Gastroenterology2013，19，10： | 9 |
| 11 | Analysis of the microbiota of sputum samples from patients with lower respiratory tract infections显示文摘唾沫是从患更低的呼吸的道感染的病人收集的最普通的样品,它为这些感染的细菌的鉴定是关键的。在这研究,我们与更低的呼吸的道感染从 101 个病人注册了 101 件唾沫样品。开始,在唾沫包含的细菌的 16S rDNA V3 hypervariable 区域的 pyrosequencing 为 microbiota 分析作为一条文化无关的途径被利用。为比较,用一个文化依赖者的临床的实验室测试为样品也被做的唾沫的一样的队自动化了细菌的鉴定系统。由 pyrosequencing, > 70,000 DNA 碎片在被 Ribosomal 数据库工程(RDP ) 过程分析以后被发现并且分类进 129 个细菌的类。大多数序列属于几个占优势的类,例如链球菌和葡萄球菌,显示这些类起在更低的呼吸的道感染的一个重要作用。另外,属于潜在的原因的代理人的一些序列例如霉浆菌, Haemophilus,和 Moraxella,也被发现,但是这些序列没被临床的实验室测试发现。为两个方法检测的九个类,方法的敏感被比较,结果证明 pyrosequencing 是更敏感的,除了 Klebsiella 和 Mycobacterium。显著地,这个方法揭示了更复杂的细菌的社区,它为细菌的察觉显示出一个有希望的能力。 | Yuhua Zhou Ping Lin Qingtian Li Lizhong Han Huajun Zheng Yanxia Wei Zelin Cui Yuxing Ni Xiaokui Guo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，10： | 8 |
| 12 | 氟哌噻吨美利曲辛联合布拉酵母菌治疗伴焦虑抑郁症状的腹泻型肠易激综合征患者的效果观察显示文摘目的观察氟哌噻吨美利曲辛联合布拉酵母菌治疗伴有焦虑抑郁症状的腹泻型肠易激综合征(irritable bowel syndrome,IBS)患者的临床效果观察。方法选择2013年1月至2015年1月住院治疗的伴有焦虑抑郁症状的腹泻型IBS患者病例共120例,分为联合治疗组和对照组,每组60例。联合治疗组用氟哌噻吨美利曲辛加口服布拉酵母菌,对照组仅口服布拉酵母菌,疗程4周。治疗前、治疗1周后、治疗4周后比较评估2组患者胃肠道症状和情绪障碍,同时观察2组患者不良症状。结果治疗1周后,对照组和联合治疗组患者的胃肠道症状改善有效率分别为23.3%(14/60)和31.7%(19/60),差异无统计学意义(P>0.05),汉密尔顿抑郁量表(Hamilton’s depression scale,HAMD)评分改善的有效率分别为11.8%(6/51)和33.3%(19/57),汉密尔顿焦虑量表(Hamilton’s anxiety scale,HAMA)评分中症状改善的有效率分别为16.1%(9/56)和35.6%(21/59),差异有统计学意义。治疗4周后,联合治疗组和对照组胃肠道症状改善有效率分别为93.0%(53/57)和74.1%(43/58),HAMD评分改善有效率分别为64.8%(35/54)和34.7%(17/49);HAMA评分中症状改善有效率分别为80.4%(45/56)和35.2%(19/54),差异均有统计学意义(χ2=5.679,P=0.017;χ2=23.056,P<0.01)。治疗1周后,联合治疗组和对照组患者不良症状发生率为5.0%(3/60),治疗4周后,联合治疗组和对照组患者不良症状发生率分别为3.5%(2/57)和3.4%(2/58)。2组不良症状发生率差异无统计学意义(P>0.05)。结论氟哌噻吨美利曲辛与布拉酵母菌联合治疗不仅可有效改善腹泻型IBS患者的焦虑抑郁症状,同时能够有效改善患者的消化道症状,其治疗效果明显优于单用布拉酵母菌进行治疗。 | 王丹 张丽莉 | 2018 | 河北医药2018，40，4： | 7 |
| 13 | 山楂酸对腹泻型肠易激综合征的作用研究显示文摘本文探究了山楂酸是否对腹泻型肠易激综合征有治疗作用,实验分空白组,模型组,阳性对照组和山楂酸高、低剂量共5组,运用乙酸-束缚联合刺激法建立了大鼠腹泻型肠易激综合征模型,检测分析了粪便含水量、腹腔回缩反射、离体肠肌动力、结肠组织病理染色、5-羟色胺免疫组化等多项体内体外指标。实验结果显示在体实验中,山楂酸高剂量组可明显改善大鼠稀便状况,且可使腹腔回缩反射恢复至正常范围,作用效果与阳性药相当,低剂量的山楂酸也表现出一定作用,但效果较弱;离体实验中,五组均无病理变化;高剂量山楂酸可恢复结肠对乙酰胆碱、5-羟色胺的正常敏感度,且使5-羟色胺免疫组化反应阳性的肠嗜铬细胞减少。本研究得出,山楂酸对腹泻型肠易激综合征有一定的治疗效果,且高剂量优于低剂量。 | 王淇漫 李晓斐 陶莉 谢剑梅 李建 丁虹 王诗 | 2015 | 现代食品科技2015，31，1： | 6 |
| 14 | 肉桂精油对小鼠肝肠组织抗氧化能力以及肠道菌群结构的调节作用显示文摘目的:探究肉桂精油对小鼠肝脏代谢相关酶活性,肝、十二指肠、结肠组织抗氧化能力及肠道菌群的影响,评价肉桂精油的摄入对机体健康的潜在影响。方法:将8周龄C57雄性小鼠随机分为3组:对照组和肉桂精油低、高剂量(100、300 mg/(kg·d))组;饲养4周后测定小鼠体质量、肝脏代谢相关酶活性以及肝、十二指肠、结肠组织抗氧化能力,运用Illumina高通量测序技术测定小鼠肠道菌群的变化情况,利用气相色谱-质谱联用仪检测小鼠粪便中短链脂肪酸含量变化情况。结果:肉桂精油的摄入能够显著降低小鼠腹脂指数,使肝脏丙氨酸氨基转移酶活力、肠道抗氧化能力显著提高(P<0.05);摄入肉桂精油后,在门水平上小鼠粪便中软壁菌门(Tenericutes)相对丰度显著降低(P<0.05),在属水平上布劳特氏菌属(Blautia)、真杆菌属([Eubacterium]_fissicatena_group)等条件致病菌相对丰度显著降低(P<0.05),罗氏菌属(Roseburia)、粪芽孢菌属(Coprobacillus)等有益菌相对丰度显著上升(P<0.05);肉桂精油高剂量组小鼠粪便中乙酸、丙酸、总酸的含量显著降低(P<0.05)。结论:肉桂精油的摄入能够调节肠道氧化还原状态平衡和肠道菌群结构,抑制致病菌群生长,促进有益菌群增殖,具有潜在促进机体健康的作用。 | 肖瀛 许豪杰 杨昌铭 宋晓秋 周小理 | 2021 | 食品科学2021，42，7： | 6 |
| 15 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 16 | 运用454焦磷酸测序技术对病原菌16S-rDNA的分析显示文摘目的探讨运用测序技术鉴定临床感染标本中病原菌的应用价值。方法运用聚合酶链反应(PCR)扩增及454焦磷酸测序技术,对标本中病原菌16S-rDNA V3区进行多样性分析;并与细菌培养结果相比较。结果测序能检测出临床不宜培养的菌属,如支原体属、嗜血杆菌属、莫拉菌属等;9种菌属为2种方法共同检测所得,7种菌属的P值均<0.05。结论 2种方法的检测敏感性差异有统计学意义;与细菌培养相结合是临床实践中的一种新的偿试。 | 林萍 周与华 李擎天 郭晓奎 | 2011 | 检验医学2011，26，6： | 5 |
| 17 | 肠道菌群检测方法学评价及其在肠易激综合征中的应用显示文摘正常情况下,肠道菌群组成的微生态系统对肠道功能和免疫防御等有着极其重要的作用,但肠道感染或抗生素的使用可能打破菌群平衡,从而表现出胃肠道症状,如肠易激综合征(IBS)。大量的IBS研究业已表明肠道菌群分析在肠道疾病的诊断和治疗中的重要价值。随着生物技术的发展,菌群分析的方法学也取得了较大进展。了解各种菌群分析的方法学特点并合理运用,对于保证肠道菌群检测的准确性及其临床应用具有重要意义。 | 朱义芳 赵聪 孙晓滨 郭元彪 | 2011 | 国际消化病杂志2011，31，2： | 5 |
| 18 | 健脾清化法联合微生态制剂治疗腹泻型肠易激综合征48例临床观察显示文摘[目的]观察健脾清化法联合微生态制剂治疗腹泻型肠易激综合征(D-IBS)的临床疗效。[方法]选取江苏省中医院2014年1月-2014年6月消化内科门诊收治的48例D-IBS患者作为分析研究对象,随机分为观察组和对照组,每组24例。2组患者均予以口服枯草杆菌二联活菌胶囊,500 mg/次,3次/d(或双歧杆菌三联活菌胶囊,3粒/次,2次/d),观察组加用孙志广教授健脾清化经验方口服。疗程4周,观察2组总体治疗效果。[结果]2组治疗前后腹痛、腹泻、腹胀积分比较,差异均有统计学意义(P〈0.05);2组腹痛、腹泻、腹胀疗效比较,差异无统计学意义(P〉0.05);2组中医证候疗效比较,差异有统计学意义(P〈0.05)。[结论]健脾清化法联合微生态制剂治疗D-IBS(中医辨证为脾虚湿热型)疗效肯定,未见明显不良反应,可明显改善生活质量,是临床中治疗该类患者值得推广使用的办法。 | 郭晨希 孙志广 肖君 | 2016 | 中国中西医结合消化杂志2016，24，6： | 4 |
| 19 | NEC发病机制及诊断方法的研究进展显示文摘新生儿坏死性小肠结肠炎(NEC)是新生儿尤其是早产儿常见的消化道严重的疾病之一,其严重影响新生儿生命及生存质量。由于NEC发病因素具有多源性,目前NEC机制尚未完全阐明。如能及早预防和诊断NEC病变并给予合适的早期干预措施,对降低其发病率和提高NEC治愈率非常关键。因此,有关NEC的损伤机制、保护机制及诊断方法的研究,对预防和治疗NEC具有重要临床意义。 | 蔺小培 顾志成 | 2013 | 中国妇幼健康研究2013，24，4： | 4 |
| 20 | 芽孢杆菌对肠道菌群结构影响的研究进展显示文摘芽孢杆菌是肠道中正常菌群的重要组成成分,其主要为纳豆芽孢杆菌、地衣芽孢杆菌、枯草芽孢杆菌、苏云金芽孢杆菌等。芽孢杆菌通过对肠道的黏附和对致病菌的拮抗,维持肠道菌群平衡,保护肠道健康。从芽孢杆菌调节肠道菌群的方式和肠道菌群研究方法来系统地阐述芽孢杆菌对肠道菌群结构的影响。 | 吴高峰 黄占旺 | 2014 | 生物灾害科学2014，37，3： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员