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| 1 | Effect of curcumin on expressions of NF-κBp65,TNF-αand IL-8 in placental tissue of premature birth of infected mice显示文摘Objective:To observe the effect of curcumin on expressions of nuclear transcription factorkappa Bp65(NF-κBp65),TNF--α and IL-8 in placental tissue of premature birth of infected mice induced by lipopolysaccharide(LPS).Methods:A total of 60 C57BL/6 mice pregnant with 15 d were collected and randomly divided into control group,model group,treatment group and preventative group.LPS was repeatedly injected in abdominal cavity to construct infected premature birth model,while mice of control group were given with 100 mg/kg of vitamin C through abdominal cavity injection and mice of treatment group and preventative group were given curcumin of 100 mg/kg through abdominal cavity injection after modeling operation and before 1 d of modeling operation,respectively.A total of 5 mice of four groups respectively were executed by cervical dislocation after 6 h,12 h and 24 h after constructing model.Placental tissues were collected and the immunohistochemical mothod SABC of immunologic tissue was used to detect the expression of NF-d mice after 24 h was collected tκBp65,TNF-o detect the co-and IL-8 and peripheral blood of executencentrations of IL-8,malondialdehyde(MDA) and superoxide dismutase(SOD),meanwhile live birth rate of four groups was contrasted.Results:Staining intensity of NF-tissue of treatment group and preventative group was κBp65,TNF-significantly-αand IL-8 in placental higher than control group but lower than model group(P<0.05).Level of serum IL-8 and MDA of control group was significantly lower than the other three groups(P<0.05) and level of blood of SOD in model group was significantly lower than control group(P<0.05).Levels of serum IL-8 and MDA of treatment group and preventative group were significantly lower than model group(P<0.05) while level of SOD was significantly higher than model group(P<0.05).Live birth rate of treatment group and preventative group was significantly higher than model group(P<0.05).Conclusions:Curcumin can effectively prevent the active pathway of NF-t tissue of premature birth of infected mice,reduce the expression of TNF-κB in pregnanieve the damage of lipid peroxide of oxidative stress of LPS on mother-fetus-α and IL-8 and rel and further to achieve the objective of preventing and curing premature birth induced with infection. | Yan-Zi Guo Ping He Ai-Min Feng | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，2： | 14 |
| 2 | 新生儿早发型败血症预后不良的预测因素显示文摘目的探讨新生儿早发型败血症(EOS)预后不良的预测因素。方法收集371例EOS新生儿的临床资料,根据预后分为预后良好组(264例)和预后不良组(107例)。比较两组患儿的围生期特点、临床表现、实验室指标、合并症、治疗过程等,采用多因素logistic回归模型分析EOS预后不良的预测因素。结果预后不良组患儿的出生体重、胎龄均低于预后良好组(P<0.05);预后不良组的早产、低出生体重、极低出生体重及双胎比例高于预后良好组(P<0.05);预后不良组母亲产前使用激素、产前使用抗生素比例高于预后良好组(P<0.05);预后不良组反应差和呼吸功能低下的发生率高于预后良好组,皮肤黄染发生率低于预后良好组(P<0.05);预后不良组WBC<5×10^9/L、血小板<100×10^9/L、贫血、凝血功能障碍、肾功能损害、肝功能损害、低蛋白血症及低血糖的发生率高于预后良好组(P<0.05);预后不良组新生儿呼吸窘迫综合征、肺出血、坏死性小肠结肠炎、脑出血、脑损伤、肺动脉高压及休克的发生率高于预后良好组(P<0.05);预后不良组住院时间和抗生素疗程长于预后良好组(P<0.05);预后不良组使用机械通气和血管活性药的比例高于预后良好组(P<0.05)。多因素logistic回归分析显示,极低出生体重(OR=41.734)、坏死性小肠结肠炎(OR=12.669)、脑损伤(OR=8.372)、休克(OR=5.889)、机械通气(OR=5.456)及肝功能损害(OR=4.075)是新生儿EOS预后不良的独立预测因素(P<0.05)。结论极低出生体重、机械通气及合并坏死性小肠结肠炎、脑损伤、休克或肝功能损害对新生儿EOS预后不良有预测价值。 | 陈洁 余加林 | 2020 | 中国当代儿科杂志2020，22，2： | 12 |
| 3 | 早产儿早发型败血症的临床特点和危险因素调查显示文摘目的探讨早产儿早发型败血症(EOS)的临床特点及其危险因素。方法选取2018年1月-2020年1月该院收治的119例EOS早产儿为EOS组,随机选取357例未发生败血症的早产儿为对照组,进行回顾性病例对照研究。采用χ^(2)检验进行组间单因素比较,采用Logistic回归法进行早产儿发生EOS的相关危险因素筛查。结果两组间的母亲年龄、GDM、HDCP、胎盘早剥、胎膜早破、生殖道感染、胎儿窘迫、羊水污染、产时发热、剖宫产、极低出生体质量、机械通气、新生儿黄疸、新生儿窒息及新生儿肺部感染等因素比较,差异均有统计学意义(均P<0.05)。多因素结果显示,胎膜早破(OR=3.294)、生殖道感染(OR=5.129)、胎儿窘迫(OR=3.702)、羊水污染(OR=5.675)、产时发热(OR=6.626)、极低出生体质量(OR=2.881)、新生儿窒息(OR=2.989)及新生儿肺部感染(OR=3.411)等为影响早产儿发生EOS的危险因素。结论早产儿发生EOS的独立危险因素包括胎膜早破、生殖道感染、新生儿窒息、产时发热、极低出生体质量及新生儿肺部感染等,应根据这些高危因素,早预防、早诊断、早治疗EOS,改善EOS早产儿的预后。 | 郏晓君 胡玲芝 | 2021 | 中国妇幼保健2021，36，17： | 5 |
| 4 | 新生儿早发败血症病原分析与抗菌药物治疗显示文摘新生儿败血症是新生儿期细菌进入血液循环并生长繁殖产生毒素,引起的全身性感染。新生儿早发败血症(early-onset neonatal sepsis,EOS)是指发病时间在生后7 d或72 h以内的新生儿败血症。不同中心对发病时间限定不同,疾病预防控制中心(CDC)定义早发败血症为生后7 d,美国儿科学会胎儿和新生儿委员会(AAPCOFN)把收入NICU的极低体质量儿的早发败血症时限规定为生后72 h。 | 葛丽园 韦红 | 2018 | 儿科药学杂志2018，24，11： | 4 |
| 5 | 低分子肝素治疗新生儿败血症的效果显示文摘目的探讨低分子肝素治疗新生儿败血症的有效性。方法收集2015年3月~2016年7月我院58例新生儿败血症患儿,按照入院顺序分成观察组与对照组,每组29例,对照组患儿实施传统抗生素类药物治疗,观察组患儿在对照组的基础上予以低分子肝素治疗,对比两组患儿临床治疗效果及治疗前后降钙素原(PCT)、C反应蛋白(CRP)水平变化。结果观察组患儿总有效率为96.55%,高于对照组的86.21%,差异有统计学意义(P<0.05)。观察组治疗后PCT和CRP为(0.29±0.17)ng/L和(5.52±2.37)mg/L,明显低于治疗前的(5.65±2.18)ng/L和(22.70±5.29)mg/L(P<0.05);观察组治疗后PCT、CRP明显低于对照组,差异有统计学意义(P<0.05)。结论低分子肝素联合抗生素治疗新生儿败血症具有明显的临床效果,可明显改善PCT、CRP,临床应用价值较高。 | 杜佩珍 潘文中 廖沛娜 | 2017 | 中国当代医药2017，24，3： | 3 |
| 6 | 早产儿颅内出血的围生期危险因素分析显示文摘目的分析早产儿颅内出血的围生期危险因素。方法选取2014年3月至2019年3月中山市博爱医院收治的170例早产儿颅内出血患儿为研究组,选取同期住院治疗的170例无颅内出血早产儿为对照组,分析筛选可能的围生期危险因素。结果两组患者出生体质量、孕周、出生周患儿抽搐、宫内窘迫等围生因素比较,差异有统计学意义(P<0.05),为早产儿颅内出血的危险因素。结论出生体质量、孕周、出生周患儿抽搐、宫内窘迫等围生期因素对早产儿颅内出血发生具有一定影响,需尽早进行预防。 | 杨春晖 杨冰岩 王霞 彭嘉恒 冯明华 赖春华 罗师 | 2020 | 临床医学2020，40，4： | 0 |
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