A case of intrahepatic clear cell cholangiocarcinoma

查看全文 作　　者：Eo [1]Toriyama;Atsushi [2]Nanashima;Hideyuki [3]Hayashi;Kuniko [1]Abe;Naoe [1]Kinoshita;Shunsuke [1]Yuge;Takeshi [2]Nagayasu;Masataka [3]Uetani;Tomayoshi [1]Hayashi 机构地区：[1]Department of Pathology,Nagasaki University Hospital,Nagasaki 852-8501,Japan;[2]Division of Surgical 4Oncology,Nagasaki University Graduate School of Biomedical Sciences,Nagasaki 852-8523,Japan;[3]Department of Radiological Sciences,Nagasaki University Graduate School of Bio-medical Sciences,Nagasaki 852-8523,Japan 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第20期,共6页 摘　　要：Intrahepatic clear cell cholangiocarcinoma is very rareonly 8 cases have been reported.A 56-year-old Japanese man with chronic hepatitis B infection was diagnosed with a 2.2 cm hepatocellular carcinoma on imaging,and hepatic segmentectomy was performed.Histopathologically,the tumor cells had copious clear cytoplasm and formed glandular structures or solid nests.These pathological findings suggested the tumor was a clear cell variant of intrahepatic cholangiocarcinoma.Particular stains and radiological images suggested that the cause of the clear cell change had been glycogen,not mucin nor lipid.On immunohistochemical staining,cytokeratin(CK)7 and CK19 were positive,whereas CK20 was negative.Vimentin was detected on the cell membranes,and CD56 was focally positive.The patient was given adjuvant chemotherapy and is currently free from the tumor 7 mo postoperatively.Careful follow-up with adequate postoperative supplementary chemotherapy is necessary because the characteristics of this type of tumor are unknown. 关 键 词：Intrahepatic cholangiocarcinoma Clear cell carcinoma GLYCOGEN MUCIN LIPID HEPATECTOMY