Diarrhea in neonatal intensive care unit

查看全文 作　　者：Annalisa [1]Passariello;Gianluca [1]Terrin;Maria Elisabetta [2]Baldassarre;Mario De [3]Curtis;Roberto [1]Paludetto;Roberto Berni [1,4]Canani 机构地区：[1]Department of Pediatrics,University of Naples 'Federico Ⅱ',Naples,80131,Italy;[2]Department of Evolutive Age Biomedicine,University of Bari,Bari,70124,Italy;[3]Neonatal Care Unit,University La Sapienza,Rome,00161,Italy;[4]European Laboratory for Investigation on Food-Induced Diseases,University of Naples 'Federico Ⅱ',Naples,80131,Italy 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第21期,共5页 摘　　要：AIM:To investigate the frequency,etiology,and current management strategies for diarrhea in newborn.METHODS:Retrospective,nationwide study involving 5801 subjects observed in neonatal intensive care units during 3 years.The main anamnesis and demographic characteristics,etiology and characteristics of diarrhea,nutritional and therapeutic management,clinical outcomes were evaluated.RESULTS:Thirty-nine cases of diarrhea(36 acute,3 chronic) were identified.The occurrence rate of diarrhea was 6.72 per 1000 hospitalized newborn.Etiology was defined in 29 of 39 newborn(74.3%):food allergy(20.5%),gastrointestinal infections(17.9%),antibiotic-associated diarrhea(12.8%),congenital defects of ion transport(5.1%),withdrawal syndrome(5.1%),Hirschsprung's disease(2.5%),parenteral diarrhea(2.5%),cystic fibrosis(2.5%),and metabolic disorders(2.5%).Three patients died due to complications related to diarrhea(7.7%).In 19 of 39 patients(48.7%),rehydration was performed exclusively by the enteral route.CONCLUSION:Diarrhea in neonates is a challenging clinical condition due to the possible heterogeneous etiologies and severe outcomes.Specific guidelines are advocated in order to optimize management of diarrhea in this particular setting. 关 键 词：Chronic diarrhea Congenital diarrhea Food allergy Oral rehydration solution ROTAVIRUS