Increased levels of homocysteine in patients with ulcerative colitis

查看全文 作　　者：Sabiye [1]Akbulut;Emin [2]Altiparmak;Firdevs [3]Topal;Ersan [2]Ozaslan;Metin [4]Kucukazman;Ozlem [5]Yonem 机构地区：[1]Department of Gastroenterology, Kartal Kosuyolu High Specialty Education and Research Hospital, 34846 Istanbul, Turkey;[2]Department of Gastroenterology, Ankara Numune Training and Education Hospital, 06443 Ankara, Turkey;[3]Department of Gastroenterology, ankiri State Hospital, 18200 Cankiri, Turkey;[4]Department of Gastroenterology, Kecioren Teaching and Research Hospital, 06380 Ankara, Turkey;[5]Department of Gastroenterology, Cumhuriyet University, Cumhuriyet Universitesi Hastanesi, 58140 Sivas, Turkey 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第19期,共6页 摘　　要：AIM: To investigate serum levels of homocysteine (Hcys) and the risk that altered levels carry for thrombosis development in ulcerative colitis (UC) patients. METHODS: 55 UC patients and 45 healthy adults were included. Hcys, vitamin B12 and folic acid levels were measured in both groups. Clinical history and thrombo- embolic events were investigated. RESULTS: The average Hcys level in the UC patients was 13.3 ± 1.93 μmmol/L (range 4.60-87) and was higher than the average Hcys level of the control group which was 11.2 ± 3.58 μmmol/L (range 4.00-20.8) (P < 0.001). Vitamin B12 and folic acid average values were also lower in the UC group (P < 0.001). Whenmultivariate regression analysis was performed, it was seen that folic acid deficiency was the only risk factor for hyperhomocysteinemia. Frequencies of thromboembolic complications were not statistically significantly different in UC and control groups. When those with and without a thrombosis history in the UC group were compared according to Hcys levels, it was seen that there were no statistically significant differences. A negative linear relationship was found between folic acid levels and Hcys. CONCLUSION: We could not find any correlations between Hcys levels and history of prior thromboembolic events. 关 键 词：Ulcerative colitis HOMOCYSTEINE Folate Vitamin B12