Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis

查看全文 作　　者：Qu, Xin-[1]Hua;Huang, Xiao-[1]Lu;Xiong, [2]Ping;Zhu, Cui-[1]Ying;Huang, You-[3]Liang;Lu, Lun-[4]Gen;Sun, [5]Xu;Rong, [5]Lan;Zhong, [5]Liang;Sun, Da-[5]Yu;Lin, [6]Hai;Cai, Ming-[1]Ci;Chen, Zhi-[1]Wei;Hu, [1]Bing;Wu, Lian-[1]Ming;Jiang, Yi-[5]Bin;Yan, Wei-[1]Li 机构地区：[1]Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Shanghai 200127, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Shanghai 200011, Peoples R China;[3]Indiana Univ, Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA;[4]Shanghai Inst Digest Dis, Shanghai 200001, Peoples R China;[5]Fudan Univ, Huashan Hosp, Dept Gastroenterol, Shanghai 200040, Peoples R China;[6]Shanghai Hlth Dev Res Ctr, Shanghai 200040, Peoples R China 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第7期,共11页 基　　金：Supported by(in part)The National Natural Science Foundation of China,No.30770599;China Postdoctoral Science Foundation,No.2005038143;Shanghai Municipal Education Commission,No.09YZ82;Shanghai Leading Academic Discipline Project,No.S30203 摘　　要：AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(H.pylori)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search Medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of Controlled Trials,Premedline and Healthstar.Odds ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between control and intervention groups.RESULTS:Fifteen observational studies and 5 RCTs were identified and used for calculation.The pooled OR for observational studies was 2.22(95%CI:1.52-3.24,P<0.0001).The WMD for hemoglobin(HB) was 4.06 g/L(95%CI:-2.57-10.69,P=0.01),and the WMD for serum ferritin(SF)was 9.47μg/L(95%CI:-0.50-19.43,P<0.0001).Results were heterogeneous for all comparisons.CONCLUSION:This meta-analysis on observational studies suggests an association between H.pylori and IDA.In RCTs,eradication of H.pylori can improve HB and SF levels but not significantly. 关 键 词：Helicobacter pylori Iron-deficiency anemia META-ANALYSIS HEMOGLOBINS Odds ratio