Magnetic resonance spectroscopy to study hepatic metabolism in diffuse liver diseases, diabetes and cancer

查看全文 作　　者：Pieter C [1]Dagnelie;Susanne Leij-[1]Halfwerk 机构地区：[1]Department of Epidemiology, Maastricht University 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第13期,共10页 摘　　要：This review provides an overview of the current state of the art of magnetic resonance spectroscopy (MRS) in in vivo investigations of diffuse liver disease. So far, MRS of the human liver in vivo has mainly been used as a research tool rather than a clinical tool. The liver is particularly suitable for static and dynamic metabolic studies due to its high metabolic activity. Furthermore, its relatively superfi cial position allows excellent MRS localization, while its large volume allows detection of signals with relatively low intensity. This review describes the application of MRS to study the metabolic consequences of different conditions including diffuse and chronic liver diseases, congenital diseases, diabetes, and the presence of a distant malignancy on hepatic metabolism. In addition, future prospects of MRS are discussed. It is anticipated that future technical developments such as clinical MRS magnets with higher fi eld strength (3 T) and improved delineation of multicomponent signals such as phosphomonoester and phosphodiester using proton decoupling, especially if combined with price reductions for stable isotope tracers, will lead to intensifi ed research into metabolic syndrome, cardiovascular disease, hepato-biliary diseases, as well as non-metastatic liver metabolism in patients with a distant malignant tumor. 关 键 词：CANCER CIRRHOSIS DIABETES Diffuse liver disease HEPATITIS Magnetic resonance spectroscopy