Hypoxia,angiogenesis and liver fibrogenesis in the progression of chronic liver diseases

查看全文 作　　者：Claudia [1]Paternostro;Ezio [2]David;Erica [1]Novo;Maurizio [1]Parola 机构地区：[1]Department of Experimental Medicine and Oncology,Interuniversity Centre for Hepatic Pathophysiology,University of Torino;[2]Department of Pathology,San Giovanni Battista Hospital 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第3期,共8页 摘　　要：Angiogenesis is a dynamic,hypoxia-stimulated and growth factor-dependent process,and is currently referred to as the formation of new vessels from preexisting blood vessels.Experimental and clinical studies have unequivocally reported that hepatic angiogenesis,irrespective of aetiology,occurs in conditions of chronic liver diseases(CLDs) characterized by perpetuation of cell injury and death,inflammatory response and progressive fibrogenesis.Angiogenesis and related changes in liver vascular architecture,that in turn concur to increase vascular resistance and portal hypertension and to decrease parenchymal perfusion,have been proposed to favour fibrogenic progression of the disease towards the end-point of cirrhosis.Moreover,hepatic angiogenesis has also been proposed to modulate the genesis of portal-systemic shunts and increase splanchnic blood flow,thus potentially affecting complications of cirrhosis.Hepatic angiogenesis is also crucial for the growth and progression of hepatocellular carcinoma.Recent literature has identified a number of cellular and molecular mechanisms governing the cross-talk between angiogenesis and fibrogenesis,with a specifi c emphasis on the crucial role of hypoxic conditions and hepatic stellate cells,particularly when activated to the myofibroblast-like pro-fibrogenic.Experimental anti-angiogenic therapy has been proven to be effective in limiting the progression of CLDs in animal models.From a clinical point of view,anti-angiogenic therapy is currently emerging as a new pharmacologic intervention in patients with advanced fibrosis and cirrhosis. 关 键 词：Chronic liver diseases Hepatic myofi broblasts HYPOXIA Liver angiogenesis Liver fi brogenesis