Protective effects of cyclosporine A on T-cell dependent ConA-induced liver injury in Kunming mice

查看全文 作　　者：Xiu-Li Zhang Qi-Zhen Quan Zi-Qin Sun Yao-Jun Wang Xue-Liang Jiang Dong-Wang Wen-Bo Li Department of Gastroenterology,General Hospital of Jinan Military Command,Jinan 250031,Shandong Province,China

出　　处：《World Journal of Gastroenterology》索引2001年第7卷第4期,共3页

摘　　要：INTRODUCTIONThe T-cell dependent specific liver injury in mice induced by concanavalin A(ConA) is a newly cstablished experimental liver injury model,which is considered more eligible for the study on pathophysiology of several human liver discascs,such as viral hepatitis and autommune hepatitis[1-9].T cell activation and several cytokines release had been proven to play a critical role in ConA -induced liver injury[10-19].Cyclosprine A(CsA),an effective inhibitor of activation of T lymphocytc,hes been used widely in clinical treatment,especially in autoimmune diseases and organ transplantation[20-25].In this study,we investigated the possible effect of CsA on ConA-induced liver injury in Kunning mice. 关键词：liver/injury concanavalin A/adverse effects cyclosprine/pharmacology tumor NECROSIS factor disease models, animal

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Protective effects of cyclosporine A on T-cell dependent ConA-induced liver injury in Kunming mice

参考文献(39)

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耦合文献(148)

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