Interleukin-21 triggers effector cell responses in the gut

查看全文 作　　者：Daniela De [1]Nitto;Massimiliano [1]Sarra;Francesco [1]Pallone;Giovanni [1]Monteleone 机构地区：[1]Department of Internal Medicine,University 'Tor Vergata' of Rome 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第29期,共4页 基　　金：Supported by Fondazione Umberto di Mario,Rome,the Broad Medical Research Program Foundation (Grant No. IBD-0154R)and Giuliani SpA,Milan,Italy 摘　　要：In the gut of patients with Crohn's disease and patients with ulcerative colitis,the major forms of inflammatory bowel diseases(IBD) in humans,the tissue-damaging immune response is mediated by an active cross-talk between immune and non-immune cells.Accumulating evidence indicates also that cytokines produced by these cells play a major role in initiating and shaping this pathologic process.One such cytokine seems to be interleukin(IL)-21,a member of the common γ-chainreceptor family.IL-21 is produced in excess in the in-flamed intestine of patients with IBD mostly by activated CD4+ T helper cells co-expressing interferon-γ and follicular T helper cells.Moreover,both in vitro and in vivo studies indicate that excessive IL-21 production leads to the activation of multiple signaling pathways that expand and sustain the ongoing mucosal inflammation.In this article,we review the available data supporting the pathogenic role of IL-21 in IBD. 关 键 词：INTERLEUKIN-21 GUT T cells Epithelial cells FIBROBLASTS