Fresh frozen plasma transfusion does not affect outcomes following hepatic resection for hepatocellular carcinoma

查看全文 作　　者：Yoshito [1]Tomimaru;Hiroshi [1]Wada;Shigeru [1]Marubashi;Shogo [1]Kobayashi;Hidetoshi [1]Eguchi;Yutaka [1]Takeda;Masahiro [1]Tanemura;Takehiro [1]Noda;Koji [2]Umeshita;Yuichiro [1]Doki;Masaki [1]Mori;Hiroak [1]Nagano 机构地区：[1]Department of Surgery,Graduate School of Medicine Osaka University;[2]Division of Health Sciences,Graduate School of Medicine,Osaka University 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第44期,共8页 摘　　要：AIM:To investigate whether fresh frozen plasma (FFP) transfusion affects outcomes following hepatic resection for hepatocellular carcinoma (HCC) in terms of liver function,postoperative complications and cancer prognosis.METHODS:We retrospectively compared the incidence of postoperative complications between 204 patients who underwent hepatectomy for HCC with routine FFP transfusion in an early period (1983-1993,Group A) and 293 with necessity for FFP transfusion during a later period (1998-2006,Group B),and also between two subgroups of Group B [22 patients with FFP transfusion (Group B1) and 275 patients without FFP transfusion (Group B2)].Additionally,only in limited patients in Group B1 and Group B2 with intraoperative blood loss≥ 2000 mL (Group B1 ≥ 2000 mL and Group B2 ≥ 2000 mL),postoperative complications,liver function tests,and cancer prognosis were compared.RESULTS:No mortality was registered in Group B,compared to 8 patients (3.9%) of Group A.The incidence of morbidity in Group B2 [23.2% (64/275)] was not significantly different from Group B1 [40.9% (9/22)] and Group A [27.0% (55/204)].The incidence of complications and postoperative liver function tests were comparable between Group B1 ≥ 2000 mL vs Group B2 ≥ 2000 mL.Postoperative prognosis did not correlate with administration of FFP,but with tumor-related factors.CONCLUSION:The outcome of hepatectomy for HCC is not influenced by FFP transfusion.We suggest FFP transfusion be abandoned in patients who undergo hepatectomy for HCC. 关 键 词：Fresh frozen plasma Hepatocellular carcinoma SURGERY TRANSFUSION