Non-invasive markers of gut wall integrity in health and disease

查看全文 作　　者：Joep PM [1,2]Derikx;Misha DP [1,2]Luyer;Erik [1,3]Heineman;Wim A [1]Buurman 机构地区：[1]Department of Surgery,University Hospital Maastricht & Nutrition and Toxicology Research Institute,Maastricht University,Maastricht,6200 MD,The Netherlands;[2]Department of Surgery,Orbis Medical Centre Sittard,6162 BG,The Netherlands;[3]Department of Surgery,University Medical Centre Groningen,9713 GZ,The Netherlands 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第42期,共8页 基　　金：Supported by Grants from AGIKO-stipendium 920-03-271(to Luyer MDP);920-03-438(to Derikx JPM)from the Nether-lands Organisation for Health Research and Development 摘　　要：The intestinal mucosa is responsible for the absorption of nutrients from the lumen and for the separation of the potentially toxic luminal content(external environment) from the host(internal environment).Disruption of this delicate balance at the mucosal interface is the basis for numerous(intestinal) diseases.Experimental animal studies have shown that gut wall integrity loss is involved in the development of various inflammatory syndromes,including post-operative or post-traumatic systemic inflammatory response syndrome,sepsis,and multiple organ failure.Assessment of gut wall integrity in clinical practice is still a challenge,as it is difficult to evaluate the condition of the gut non-invasively with currently available diagnostic tools.Moreover,non-invasive,rapid diagnostic means to assess intestinal condition are needed to evaluate the effects of treatment of intestinal disorders.This review provides a survey of non-invasive tests and newly identified markers that can be used to assess gut wall integrity. 关 键 词：Intestinal damage MARKERS HUMAN Gut wall integrity