High density lipoproteins and atherosclerosis: emerging aspects

查看全文 作　　者：Federica [1]Sala;Alberico Luigi [1,2]Catapano;Giuseppe Danilo [1,3,4]Norata

机构地区：[1]Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan 20133, Italy;[2]IRCCSMult imedica, ViaMilanese 300, Sesto San Giovanni ,Milan, Italy;[3]Centro SISAper lo Studio dell’Aterosclerosi,Ospedale Bassini, Via Gorki50 Cinisello Bal samo, Italy;[4]The Blizard Institute,Barts and the LondonSchool of Medicine & Dentistry Queen Mary University, Turner Street, London E1 2AD, UK

出　　处：《Journal of Geriatric Cardiology》索引2012年第9卷第4期,共7页

摘　　要：High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant anti-atherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis,includingmonocyte-macrophages, B and T lymphocytes.Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis.

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High density lipoproteins and atherosclerosis: emerging aspects

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