Inhibition of Celastrus orbiculatus Extracts on VEGF Expression in Hepatoma Cells of Mice

查看全文 作　　者：QIAN Ya-yun,LIU Yan-qing Institute of Traditional Chinese Medicine & Western Medicine,Yangzhou University,Yangzhou 225009,China

出　　处：《Chinese Herbal Medicines》索引2010年第2卷第1期,共5页

基　　金：supported by Plans of Colleges and Universities in Jiangsu Province to Postgraduate Research and Innovation (No.CX09B-321Z);State Administration of Traditional Chinese Medicine of People’s Republic of China (No. 04-05ZP35) 摘　　要：Objective To discuss the antitumor mechanism preliminarily by observing effects of Celastrus orbiculatus extracts(COE) on vascular endothelial growth factor(VEGF) mRNA and protein expression in hepatoma(Hepa1-6) cells of mice.Methods Hepa1-6 cells were treated with COE at different nontoxic concentration(0,10,20,40,80,and 160 μg/mL) for 16 h.The mRNA and protein expressions of VEGF were detected by reverse transcription-PCR and Western Blotting,respectively.Results COE significantly inhibited VEGF expression at both mRNA and protein levels in a dose-dependent manner.Conclusion COE can inhibit VEGF expression in Hepa1-6 cells,therefore suggest that VEGF could be chosen as an therapeutic target for COE in the context of cancer chemoprevention and anticancer therapy. 关键词：Celastrus orbiculatus Thunb. TUMOR vascular endothelial growth factor

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Inhibition of Celastrus orbiculatus Extracts on VEGF Expression in Hepatoma Cells of Mice

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