Impact of hypoglycemic agents on myocardial ischemic preconditioning

查看全文 作　　者：Rosa Maria Rahmi [1]Garcia;Paulo Cury [1]Rezende;Whady [1]Hueb

机构地区：[1]MASS Study Group, Heart Institute of the University of So Paulo

出　　处：《World Journal of Diabetes》索引2014年第5卷第3期,共9页

基　　金：Supported by Zerbini Foundation 摘　　要：Murry et al in 1986 discovered the intrinsic mechanism of profound protection called ischemic preconditioning. The complex cellular signaling cascades underlying this phenomenon remain controversial and are only partially understood. However, evidence suggests that adenosine, released during the initial ischemic insult, activates a variety of G protein-coupled agonists, such as opioids, bradykinin, and catecholamines, resulting in the activation of protein kinases, especially protein kinase C(PKC). This leads to the translocation of PKC from the cytoplasm to the sarcolemma, where it stimulates the opening of the ATP-sensitive K+ channel, which confers resistance to ischemia. It is known that a range of different hypoglycemic agents that activate the same signaling cascades at various cellular levels can interfere with protection from ischemic preconditioning. This review examines the effects of several hypoglycemic agents on myocardial ischemic preconditioning in animal studies and clinical trials. 关键词：ISCHEMIC PRECONDITIONING MYOCARDIAL ISCHEMIA Coronary artery disease HYPOGLYCEMIC agents Diabetes MELLITUS

相关文献

参考文献（44）
引证文献（4）
耦合文献（18）

参考文献(44)

引证文献(4)

耦合文献(18)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Impact of hypoglycemic agents on myocardial ischemic preconditioning

参考文献(44)

引证文献(4)

耦合文献(18)

用户提示