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Colorectal cancer surveillance in patients with inflammatory bowel disease: What's new?

查看全文 作  者:Danila [1]Guagnozzi;Alfredo J [1]Lucendo 高影响力作者 机构地区:[1]Department of Gastroenterology, Hospital General de Tomelloso, 13700 Tomelloso, Ciudad Real, Spain高影响力机构 出  处:《World Journal of Gastrointestinal Endoscopy》索引2012年第4卷第4期,共9页高影响力期刊 摘  要:Several studies assessing the incidence of colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients have found an increased risk globally estimated to be 2 to 5 times higher than for the general population of the same age group. The real magnitude of this risk, however, is still open to debate. Research is currently being carried out on several risk and protective factors for CRC that have recently been identified in IBD patients. A deeper understanding of these factors could help stratify patient risk and aid specialists in choosing which surveillance program is most efficient. There are several guidelines for choosing the correct surveillance program for IBD patients; many present common characteristics with various distinctions. Current recommendations are far from perfect and have important limitations such as the fact that their efficiency has not been demonstrated through randomized controlled trials, the limited number of biopsies performed in daily endoscopic practice, and the difficulty in establishing the correct time to begin a given surveillance program and maintain a schedule of surveillance. That being said, new endoscopic technologies should help by replacing random biopsy protocols with targeted biopsies in IBD patients, thereby improving the efficiency of surveillance programs.However, further studies are needed to evaluate the cost-effectiveness of introducing these techniques into daily endoscopic practice. 关 键 词:COLONOSCOPY Colorectal cancer Crohn’s DISEASE DYSPLASIA Inflammatory BOWEL DISEASE ULCERATIVE COLITIS
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