TTF-1 positive small cell cancers:Don't think they're always primary pulmonary!

查看全文 作　　者：Laurine [1,2]Verset;Marianna [3,2]Arvanitakis;Patricia [4,2]Loi;Jean [4,2]Closset;Myriam [3,2]Delhaye;Myriam [1,2]Remmelink;Pieter [1,2]Demetter

机构地区：[1]Departments of Pathology,Erasme University Hospital;[2]Université Libre de Bruxelles,1070 Brussels,Belgium;[3]Department of Gastroenterology,Erasme University Hospital;[4]Department of Digestive Surgery,Erasme University Hospital

出　　处：《World Journal of Gastrointestinal Oncology》索引2011年第3卷第10期,共4页

基　　金：Supported by The'Fondation Yvonne Bo l'(Brussels,Bel-gium) 摘　　要：Thyroid transcription factor 1 (TTF-1) plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell carcinomas.This explains why this marker is frequently used in the search for the primary origin of metastatic endocrine tumours.Here we report on a TTF-1 expressing mixed endocrine-exocrine carcinoma of the common bile duct in a patient with pulmonary nodules that did not appear to be neoplastic.TTF-1 positivity in pulmonary and extrapulmonary neuroendocrine tumours is reviewed,and we conclude that TTF-1 expression in neuroendocrine tumours of the small-cell type are not uncommon at extrapulmonary locations.Therefore,immunohistochem-istry for TTF-1 in such tumours should be interpreted with caution. 关键词：Thyroid transcription factor 1 Small cell carcinoma Mixed endocrine-exocrine TUMOUR Common bile duct Immunohistochemistry

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TTF-1 positive small cell cancers:Don't think they're always primary pulmonary!

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