New insights on cholangiocarcinoma

查看全文 作　　者：Manuela [1]Gatto;Domenico [1]Alvaro

机构地区：[1]Division of Gastroenterology,Department of Clinical Medicine,University of Rome,'Sapienza',Polo Pontino

出　　处：《World Journal of Gastrointestinal Oncology》索引2010年第2卷第3期,共10页

摘　　要：Cholangiocarcinoma(CCA) is a devastating cancer arising from the neoplastic transformation of the biliary epithelium.It is characterized by a progressive increase in incidence and prevalence.The only curative therapy is radical surgery or liver transplantation but,unfortunately,the majority of patients present with advanced stage disease,which is not amenable to surgical therapies.Recently,proposed serum and bile biomarkers could help in the screening and surveillance of categories at risk and in diagnosing CCA at an early stage.The molecular mechanisms triggering neoplastic transformation and growth of biliary epithelium are still undef ined,but signif icant progress has been achieved in the last few years.This review deals with the most recent advances on epidemiology,biology,and clinical management of CCA. 关键词：CHOLANGIOCARCINOMA CHOLANGIOCYTES Growth FACTORS PROLIFERATION APOPTOSIS

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New insights on cholangiocarcinoma

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耦合文献(198)

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