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Neoadjuvant treatment for esophageal squamous cell carcinoma

查看全文 作  者:Yoshifumi [1]Baba;Masayuki [2]Watanabe;Naoya [1]Yoshida;Hideo [1]Baba 高影响力作者 机构地区:[1]Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University;[2]Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research高影响力机构 出  处:《World Journal of Gastrointestinal Oncology》索引2014年第6卷第5期,共8页高影响力期刊 摘  要:Squamous cell carcinoma and adenocarcinoma are types of esophageal cancer, one of the most aggressive malignant diseases. Since both histological types present entirely different diseases with different epidemiology, pathogenesis and tumor biology, separate therapeutic strategies should be developed against each type. While surgical resection remains the dominant therapeutic intervention for patients with operable esophageal squamous cell carcinoma(ESCC), alternative strategies are actively sought to reduce the frequency of post-operative local or distant disease recurrence. Such strategies are particularly sought in the preoperative setting. Currently, the optimal management of resectable ESCC differs widely between Western and Asian countries(such as Japan). While Western countries focus on neoadjuvant or definitive chemoradiotherapy, neoadjuvant chemotherapy followed by surgery is the standard treatment in Japan. Importantly, each country and region has established its own therapeutic strategy from the results of local randomized control trials. This review discusses the current knowledge, available data and information regarding neoadjuvant treatment for operable ESCC. 关 键 词:食道的癌症 有鳞的房间癌 Neoadjuvant 治疗
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