A rare cause of drug-induced hepatitis in an immunocompromised patient and the role of glutathione

查看全文 作　　者：Viplove [1]Senadhi;Deepika [2]Arora;Manish [3]Arora;Franklin [4]Marsh

机构地区：[1]Division of Gastroenterology and Hepatology and Brater Scholar,Indiana Institute for Personalized Medicine,Indiana University School of Medicine,Indianapolis,IN 46202,United States;[2]Elmhurst Hospital/Mount Sinai School of Medicine,New York City,New York,NY 10005,United States;[3]Division of Gastroenterology and Hepatology,University of Maryland and National Institute of Health,Baltimore/Washington DC,MD 21742,United States;[4]Division of Gastroenterology and Hepatology,New York Hospital-Weill Cornell Medical Center,New York City,New York,NY 10005,United States

出　　处：《World Journal of Hepatology》索引2012年第4卷第8期,共4页

摘　　要：The Food and Drug Administration (FDA) has issued a warning on numerous herbal drugs, including many popular products at General Nutrition Centers (GNC), regarding unstudied hepatotoxicity. There have been recent reports of GNC products such as hydroxycut and herbalife, causing drug-induced hepatitis. Herbal medications are over-the-counter products and are not investigated thoroughly by the FDA. Given that the mostcommon outpatient laboratory abnormality is elevated liver transaminases, a sign of hepatocellular toxicity; it is not surprising that some of these products end up causing hepatic dysfunction, especially when taken in large volume. There are numerous herbal supplements that are hepatotoxic, however, these medications have a much more significant effect in human immunodeficiency virus (HIV)/ acquired immune deficiency syndrome patients, which is secondary to depleted glutathione. We present a rare case of drug induced hepatitis secondary to herbal medications used to treat HIV and elucidate the role of glutathione depletion in immunocompromised patients. 关键词：GLUTATHIONE Human IMMUNODEFICIENCY virus ACQUIRED immune deficiency syndrome Immuno-compromised Drug induced hepatitis HEPATOTOXICITY N-ACETYLCYSTEINE Herbal MEDICATIONS

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A rare cause of drug-induced hepatitis in an immunocompromised patient and the role of glutathione

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