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Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma

查看全文 作　　者：Adriano M [1]Pellicelli;Massimo [2]Marignani;Valerio [3]Zoli;Mario [4]Romano;Aldo [5]Morrone;Lorenzo [6]Nosotti;Giuseppe [7]Barbaro;Antonio [8]Picardi;Umberto Vespasiani [8]Gentilucci;Daniele [9]Remotti;Cecilia D'[10]Ambrosio;Caterina [11]Furlan;Fabrizio [12]Mecenate;Ettore [13]Mazzoni;Ignazio [14]Majolino;Roberto [15]Villani;Arnaldo [15]Andreoli;Giorgio [16]Barbarini 高影响力作者 机构地区：[1]Liver Unit, Azienda Ospedaliera San Camillo Forlanini, Circonvallazione Gianicolense 87,00149 Rome, Italy;[2]Department of Digestive and Liver Disease,Azienda Ospedaliera Sant’Andrea,Via Grottarossa 1035/1039,000189 Rome, Italy;[3]Hematology and Bone Marrow Transplantation, Azienda Ospedaliera San Camillo Forlanini,Circonvallazione Gianicolense 87,00149 Rome, Italy;[4]Liver Unit,Ospedale Sandro Pertini,Via dei Monti Tiburtini 385,00157 Rome, Italy;[5]Azienda Ospedaliera San Camillo Forlanini,Circonvallazione Gianicolense87, 00149 Rome, Italy;[6]Medicine of Migration,National Institute for Migrant Health and Poverty, Via di S. Gallicano 25/a, 00153Rome, Italy;[7]Department of Medical Pathophysiology,University of Rome 'La Sapienza', Viale del Policlinico 155,00161 Rome, Italy;[8]Liver Unit,Campus Biomedico University,Via álvaro del Portillo 21, 00128Rome, Italy;[9]Histopathology Unit,Azienda Ospedaliera San Camillo Forlanini,Circonvallazione Gianicolense 87,00149Rome, Italy;[10]Liver Unit, Azienda Ospedaliera San Camillo Forlanini,Circonvallazione Gianicolense 87,00149 Rome, Italy;[11]Department of Infectious and Tropical Disease,University of Rome'La Sapienza',Viale del Policlinico155, 00161 Rome, Italy;[12]Liver Unit,Ospedale Villa Betania,Via Niccolò Piccolomini 27,00165 Rome,Italy;[13]Liver Unit,Policlinico Casilino,Via Casilina1049,00169 Rome, Italy;[14]Hematology and Bone Marrow Transplantation,Azienda Ospedaliera San Camillo Forlanini,Circonvallazione Gianicolense 87,00149 Rome,Italy;[15]Liver Unit,Azienda Ospedaliera San Camillo Forlanini,Circonvallazione Gianicolense 87,00149 Rome,Italy;[16]Infectious and Parasitic Diseases,Policlinico San Matteo P.zzale Golgi 2, 2710 Pavia,Italy高影响力机构 出　　处：《World Journal of Hepatology》索引2011年第3卷第11期,共7页高影响力期刊 摘　　要：AIM:To evaluate if indolent B cell-non Hodgkin's lymphoma(B-NHL) and diffuse large B-cell lymphoma(DLBCL) in hepatitis C virus(HCV) positive patients could have different biological and clinical characteristics requiring different management strategies.METHODS:A group of 24 HCV related B-NHL patients(11 indolent,13 DLBCL) in whom the biological and clinical characteristics were described and confronted.Patients with DLBCL were managed with the standard of care of treatment.Patients with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course observed.The outcomes of the different approaches were compared.RESULTS:Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent genotype.Five of the 9 patients with indolent HCV-relatedB-NHL treated with only antiviral therapy,achieved a complete response of their onco-haematological disease(55%).Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response(54%).CONCLUSION:HCV genotypes and duration of HCV infection differed between B-NHL subtypes.Indolent lymphomas can be managed with antiviral treatment,while DLBCL is not affected by the HCV infection. 关 键 词：Hepatitis C virus infection Diffuse large B cell LYMPHOMA INDOLENT LYMPHOMA Pegylated INTERFERON LYMPHOMAGENESIS
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