G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease

查看全文 作　　者：Guichun [1]Han;Richard E [2]White

机构地区：[1]Women’s Health Division,Michael E DeBakey Institute,Department of Physiology and Pharmacology,College of Veterinary Medicine and Biomedical Sciences,Texas A and M University,College Station,TX 77843,United States;[2]Department of Biomedical Sciences,Georgia Campus-Philadelphia College of Osteopathic Medicine,Suwanee,GA 30024,United States

出　　处：《World Journal of Cardiology》索引2014年第6卷第6期,共9页

基　　金：Supported by The American Heart Association,Texas Affiliate,No.7370061;the Center for Chronic Disorders of Aging,PCOM 摘　　要：Coronary heart disease(CHD) continues to be the greatest mortality risk factor in the developed world. Estrogens are recognized to have great therapeutic potential to treat CHD and other cardiovascular diseases; however,a significant array of potentially debilitating side effects continues to limit their use. Moreover,recent clinical trials have indicated that long-term postmenopausal estrogen therapy may actually be detrimental to cardiovascular health. An exciting new development is the finding that the more recently discovered G-protein-coupled estrogen receptor(GPER) is expressed in coronary arteries-both in coronary endothelium and in smooth muscle within the vascular wall. Accumulating evidence indicates that GPER activation dilates coronary arteries and can also inhibit the prolif-eration and migration of coronary smooth muscle cells. Thus,selective GPER activation has the potential to increase coronary blood flow and possibly limit the debilitating consequences of coronary atherosclerotic disease. This review will highlight what is currently known regarding the impact of GPER activation on coronary arteries and the potential signaling mechanisms stimulated by GPER agonists in these vessels. A thorough understanding of GPER function in coronary arteries may promote the development of new therapies that would help alleviate CHD,while limiting the potentially dangerous side effects of estrogen therapy. 关键词：G-protein-coupled 雌激素受体冠的动脉 G-1 动脉粥样硬化雌激素

相关文献

参考文献（11）
引证文献（4）
耦合文献（2）

参考文献(11)

引证文献(4)

耦合文献(2)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease

参考文献(11)

引证文献(4)

耦合文献(2)

用户提示