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Risk factors for postoperative pancreatic fistula in patients with insulinomas:analysis of 292 consecutive cases

查看全文 作　　者：Zhao, Yu-[1]Pei;Zhan, Han-[1]Xiang;Cong, [1]Lin;Zhang, Tai-[1]Ping;Liao, [1]Quan;Dai, Meng-[1]Hua;Cai, Li-[1]Xing;Zhu, [1]Yu 高影响力作者 机构地区：[1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Gen Surg, Beijing 100730, Peoples R China高影响力机构 出　　处：《Hepatobiliary & Pancreatic Diseases International》索引2012年第11卷第1期,共5页高影响力期刊 摘　　要：BACKGROUND:Pancreatic fistula (PF) remains the most challenging complication in pancreatic surgery,yet few published studies have focused on the risk factors for postoperative PF in patients undergoing surgery for insulinomas.METHODS:From January 1990 to February 2010,a total of 292 patients with insulinomas underwent surgery at Peking Union Medical College Hospital.Demographic data,intraoperative procedures,and postoperative data were collected.Particular attention was paid to variables associated with PF as defined by the International Study Group of Pancreatic Fistula (ISGPF).Univariate and multivariate analyses were used to identify possible risk factors for PF.RESULTS:PF was found in 132 (45.2%) patients,of whom 90 were classified into ISGPF grade A,33 grade B,and 9 grade C.Multivariate analysis showed that male patients (OR=2.56;P=0.007) and operative time >180minutes (OR=3.756;P<0.0001) were independent risk factors for clinical PF.Pancreatic resection with stapler was a protective factor for both total PF (OR=0.022;P=0.010) and clinical PF (OR=0.097;P=0.007).CONCLUSIONS:Male gender and operative time >180minutes were independent risk factors for clinical PF,while pancreatic resection with a stapler was a protective factor.Whether body mass index (BMI) and other variables during operation are risk factors of PF needs further study. 关 键 词：INSULINOMA PANCREATIC FISTULA risk factors
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