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Profile of hepatocyte apoptosis and bile lakes before and after bile duct decompression in severe obstructive jaundice patients

查看全文 作　　者：Toar JM [1]Lalisang;Raden [1]Sjamsuhidajat;Nurjati C [2]Siregar;Akmal [3,4]Taher 高影响力作者 机构地区：[1]Department of Surgery;[2]Department of Anatomical Pathology;[3]Faculty of Medicine,University of Indonesia;[4]Department of Urology,Cipto Mangunkusumo Hospital高影响力机构 出　　处：《Hepatobiliary & Pancreatic Diseases International》索引2010年第9卷第5期,共4页高影响力期刊 摘　　要：BACKGROUND:Excessive hepatocyte apoptosis and bile lakes in severe obstructive jaundice might impair liver functions.Although decompression of the bile duct has been reported to improve liver functions in animal studies,the mechanism of obstruction differs from that in humans.This study aimed to determine the profiles of hepatocyte apoptosis and bile lakes following bile duct decompression in patients with severe obstructive jaundice in the clinical setting.METHODS:We conducted a 'before and after study' on severe obstructive jaundice patients as a model of inhibition of the excessive process by bile duct decompression.Specimens of liver biopsies were taken before and after decompression of the bile duct and then stained by terminal deoxynucleotide transferase-mediated dUTP nick end-labeling(TUNEL) to identify hepatocyte apoptosis and by hematoxilin-eosin(HE) to identify bile lakes.All measurements were independently done by 2 observers.RESULTS:Twenty-one severe obstructive jaundice patients were included.In all patients,excessive hepatocyte apoptosis and bile lakes were apparent.After decompression,the hepatocyte apoptosis index decreased from 53.1(SD 105) to 11.7(SD 13.6)(P<0.05),and the bile lakes from 23.6(SD 14.8) to 10.9(SD 6.9)(P<0.05).CONCLUSION:Bile duct decompression improves hepatocyte apoptosis and bile lakes in cases of severe obstructive jaundice,similar to the findings in animal studies. 关 键 词：HEPATOCYTE apoptosis BILE LAKES TUNEL OBSTRUCTIVE JAUNDICE BILE duct DECOMPRESSION
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