A prospective study on radiofrequency ablation locally advanced pancreatic cancer

查看全文 作　　者：Riccardo [1]Casadei;Claudio [1]Ricci;Raffaele [2]Pezzilli;Carla [2]Serra;Lucia [3]Calculli;Antonio Maria Morselli-[4]Labate;Donatella [5]Santini;Francesco [1]Minni

机构地区：[1]Department of Surgery,S.Orsola-Malpighi Hospital, University of Bologna;[2]Department of Internal Medicine and Gastroenterology,S.Orsola-Malpighi Hospital, University of Bologna;[3]Department of Radiology,S.Orsola-Malpighi Hospital, University of Bologna;[4]Department of Internal Medicine and Gastroenterology;[5]Department of Pathology,S.Orsola-Malpighi Hospital, University of Bologna

出　　处：《Hepatobiliary & Pancreatic Diseases International》索引2010年第9卷第3期,共6页

摘　　要：BACKGROUND:Radiofrequency ablation(RFA)has been suggested as a new treatment option for patients with locally advanced cancer.This study aimed to prospectively evaluate the efficacy and safety of intraoperative RFA in patients with unresectable,locally advanced,non-metastatic carcinoma of the pancreatic head.METHODS:RFA was the first step of the surgical procedure and was carried out on the mobilized pancreatic head followed by biliary by-pass and gastrojejunal-anastomosis.Intra-and post-operative morbidity and mortality,performance status, pain control,quality of life,and survival at 24 months were evaluated.RESULTS:Seven patients(3 men and 4 women;median age 66 years,range 47-80 years)were studied and 4 were eligible for treatment.The RFA procedure was carried out in 3 of the 4 patients;in one patient it was not carried out because of the upstaging of the neoplasm.In all 3 patients RFA achieved complete necrosis of the lesion.A biliary fistula developed 7 days after the procedure in one patient;all 3 patients developed ascites 8.6 days(range 7-9 days)on average after RFA.All patients died respectively,at 3,4,and 5 months after the treatment.CONCLUSIONS:In our experience,RFA is a feasible procedure, but it presents a very high rate of postoperative complications.Moreover,pain control,life quality and survival rate are poor.The few data suggest no impact on survival. 关键词：PANCREATIC NEOPLASMS RADIOFREQUENCY ablation SURVIVAL EFFICACY safety

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A prospective study on radiofrequency ablation locally advanced pancreatic cancer

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