A rabbit model of non- cirrhotic portal hypertension by repeated injections of E. coli through indwelling cannulation of the gastrosplenic vein

查看全文 作　　者：Swati [1]Omanwar;Moattar R. [1]Rizvi;Rachna [1]Kathayat;Brij K. [1]Sharma;Giryesh K. [1]Pandey;Mohammad A. [1]Alam;Veena [2]Malhotra;Shiv K. [1]Sarin

机构地区：[1]Departments of Gastroenterology,G. B. Pant Hospital, New Delhi, India;[2]Departments of Pathology,G. B. Pant Hospital, New Delhi, India

出　　处：《Hepatobiliary & Pancreatic Diseases International》索引2004年第3卷第3期,共6页

基　　金：This study was financially supported by the Department of Science & Tech-nology, New Delhi, India. 摘　　要：BACKGROUND: Non-cirrhotic portal hypertension is acommon cause of portal hypertension in developing coun-tries. To understand its etiopathogenesis we developed ananimal model by repeated portal endotoxemia inducedthrough the gastrosplenic vein.METHODS: Twenty-nine rabbits (1.5-2.0 kg) were divid-ed into control (group n = 13) and experimental ( groupn = 16) groups. Heat killed E. coli were injected throughan indwelling cannula into the gastrosplenic vein in pre-sensitized animals. The animals were sacriflced at 1, 3 and6 months.RESULTS: The mean portal pressure in group animalswas significantly (P < 0. 05) higher than in group at 1(17.5 ±3.4 vs 10.4±2.2 mmHg), 3 (17.8±1.3 vs7.2 +3.6mmHg), and 6 (19.8±3.1 vs 10.3±4.8 mmHg) months.Similarly, the mean splenic weight in group was signifi-cantly greater than in group (P <0.05). Histopathologi-cally, the spleen showed medullary congestion, hemosid-rin-laden macrophages and mild fibrosis. Histologically,the liver had normal parenchyma with mild portal lympho-cytic infiltrates and kupffer cell hyperplasia. No significantanomalies were detected by liver function tests.CONCLUSIONS: The rabbit model showed significantsplenomegaly with a persistent increase in portal pressureand mild fibrosis without hepatic parenchymal injury, quiteakin to non-cirrhotic portal fibrosis as seen in humans. Re-current intra-abdominal infection may play an importantrole in the pathogenesis of non-cirrhotic portal fibrosis. 关键词：non-cirrhotic PORTAL fibrosis non-cirrhotic PORTAL HYPERTENSION PORTAL HYPERTENSION variceal bleeding PORTAL pressure animal models idiopathic PORTAL HYPERTENSION

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A rabbit model of non- cirrhotic portal hypertension by repeated injections of E. coli through indwelling cannulation of the gastrosplenic vein

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