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Protective effect of tannins from Ficus racemosa in hypercholesterolemia and diabetes induced vascular tissue damage in rats

查看全文 作　　者：Velayutham [1]Ravichandiran;Sankaradoss [1]Nirmala;KFH Nazeer [2]Ahamed 高影响力作者 机构地区：[1]Department of Pharmacognosy,School of Pharmaceutical Sciences,Vels Institute of Science Technology and Advanced Studies(VISTAS),Vels University,Pallavaram,Chennai 600 117,India;[2]Department of Pharmacology,School of Pharmaceutical Sciences.Vels Institute of Science Technology and Advanced Studies(VISTAS),Vels University,Pallavaram,Chennai 600 117,India高影响力机构 出　　处：《Asian Pacific Journal of Tropical Medicine》索引2012年第5卷第5期,共7页高影响力期刊 摘　　要：Objective:To evaluate the protective effect of tannins from Ficus racemosa(F.racemosa) on the lipid profile and antioxidant parameters in high fat meal and streptozotocin induced hypercholestremia associated diabetes model in rats.Methods:The crude tannin fraction was separated from the acetone(70%v/v) bark extract of F.racemosa.Oral administratipn of tannin fraction(TF)(100 & 200 mg/kg body weight) to rats fed with high fat meal for 30 days (4%cholesterol,1%cholic acid,0.5%egg albumin) and injected with streptozotocin(35 mg/ kg i.p.in citrate buffer on 14th day).Results:The administration of TF significantly reverse the increased blood glucose,total cholesterol,triglycerides,low density lipoprotein and also significandy restored the insulin and high density lipoprotein in the serum.In addition tannins significantly restored the activity of antioxidant enzymes such as superoxide dismutase,catalase and decreased the,glutathione peroxidase,and glutathione,thereby restoring the antioxidant status of the organs to almost normal levels.Conclutions:The results of this study show that two different doses of tannin supplementation had a favorable effect on plasma glucose and lipid profile concentrations.It also had an influence on attenuating oxidative stress in diabetic tats. 关 键 词：DIABETES VASCULAR tissue damage STREPTOZOTOCIN TANNINS Rat
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