Isolation and in vivo hep-atoprotective activity of Melothria heterophylla(Lour.) Cogn.against chemically induced liver injuries in rats

查看全文 作　　者：Arijit [1]Mondal;Tapan Kumar [1]Maity;Dilipkumar [2]Pal;Santanu [3]Sannigrahi;Jagadish [1]Singh

机构地区：[1]Department of Pharmaceutical Technology,Jadavpur University,Kolkata-700 032,India;[2]School of Pharmaceutical Sciences,IFTM University,Moradabad-244 001,India;[3]NSHM College of Pharmaceutical Technology,124 B.L Saha Road,Kolkata-700 053,West Bengal,India

出　　处：《Asian Pacific Journal of Tropical Medicine》索引2011年第4卷第8期,共5页

基　　金：University Grant commission(UGC),New Delhi,India,for providing financial assistance 摘　　要：Objective:To investigate hepatoprotective activity of ethanol extract of Melothria heterophyila Lour Cogn.(EEMH) against CCl₄-induced hepatic damage in rats.Methods:β-sitosterol was isolated by column chromatography and characterized spectroscopically.Two different doses(200 and 400 mg/kg bw) of EEMH were administered orally in alternate days.The hepatoprotective activity was studied in liver by measuring biochemical parameters such as serum aspartate amino transferase(AST),alanine amino transferase(ALT),alkaline phosphatase(ALP),total protein and total bilirubin.Lipid peroxidation product and different antioxidant enzyme activities were assessed in liver homogenate.Results:EEMH reduced all biochemical parameters and lipid peroxidation,as well as it increased the antioxidant enzyme activities in comparison with silymarin.The protective effect of the extract on CCl₄ induced damage was confirmed by histopathological examination of the liver.Conclusions:This result strongly supports the protective effect of EEMH against acute liver injury,and may be attributed to its antioxidative activity. 关键词：Carbon TETRACHLORIDE HEPATOPROTECTIVE ACTIVITY Melothria helerophylla Β-SITOSTEROL SILYMARIN

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Isolation and in vivo hep-atoprotective activity of Melothria heterophylla(Lour.) Cogn.against chemically induced liver injuries in rats

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