Evaluation of antitumour activity of Calotropis gigantea L.root bark against Ehrlich ascites carcinoma in Swiss albino mice

查看全文 作　　者：M Rowshahul [1]Habib;M Rezaul [1]karim

机构地区：[1]Department of Biochemistry and Molecular Biology,Faculty of Science,Rajshahi University,Rajshahi-6205,Bangladesh

出　　处：《Asian Pacific Journal of Tropical Medicine》索引2011年第4卷第10期,共5页

摘　　要：Objective:To investigate experimentally the possible antitumor effect of methanol extract(ME) of Calotropis gigantea L.(C.gigantean) root bark and its petroleum ether(PEF) and chloroform(CF) soluble fractions against Ehrlich ascites carcinoma(EAC) in Swiss albino mice.Methods:The effects of ME(10 and 20 mg/kg),PEF(40 and 80 mg/kg) and CF(20 and 40 mg/kg) on the growth of EAC and life span of EAC bearing mice were studied.Hematological profile and biochemical parameters(SAI.P,SGPT and SCOT) were also estimated.Results:Results of in vivo study showed a significant decrease in viable tumor cell count and a significant increase of life span in the ME and CF treated group compared to untreated one.The life span of ME and CF treated animals was significandy(P<0.05) increased by 43.90%(20 mg ME/kg) and 57.07%(40 mg CF/kg).ME and CF brought back the hematological parameter more or less normal level.ME and CF also restored the altered levels of serum alkaline phosphatase(SALP) and serum glutamate oxaloacetate transaminase(SGOT).Conclusions:Methanol extract(ME) of C.gigantea root bark and its chloroform soluble fraction(CF) possesses significant antitumor activity. 关键词：Calotropis gigantea ANTITUMOR Ehrlich ASCITES CARCINOMA ROOT BARK

相关文献

参考文献（37）
引证文献（2）
耦合文献（11）

参考文献(37)

引证文献(2)

耦合文献(11)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Evaluation of antitumour activity of Calotropis gigantea L.root bark against Ehrlich ascites carcinoma in Swiss albino mice

参考文献(37)

引证文献(2)

耦合文献(11)

用户提示