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Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats

查看全文 作　　者：Rajesh [1]Kumar;Dinesh Kumar [1]Pate;Satyendra Kuldip [1]Prasad;Kirshnamurthy [1]Sairam;Siva [1]Hemalatha 高影响力作者 机构地区：[1]Department of Pharmaceutics,Institute of Technology,Banaras Hindu University,Varanasi-221005,India高影响力机构 出　　处：《Asian Pacific Journal of Tropical Medicine》索引2011年第4卷第11期,共6页高影响力期刊 基　　金：University Grants Commission(UGC),New Delhi,for providing the financial assistance to Mr. Rajesh Kumar 摘　　要：Objective:To investigate antidiabetic potential of alcoholic leaves extract of Alangium lamarekii (A.lamarckii) on streptozotocin-nicotinamide induced type 2 diabetic rats.Methods:Oral glucose tolerance test was done by inducing hyperglycemic state via administration of glucose in water(2 g/kg).Single dose of alcoholic leaves extract of.4.lamarckii(250 and 500 mg/kg,p.o.) were administered to normoglycemic,hyperglycemic rats.Type 2 diabetes was induced by single intraperitoneal injection of nicotinamide(110 mg/kg) followed by streptozotocin(65 mg/kg).The study also included estimations of blood plasma glucose,lipid profile,liver glycogen,body weight and antioxidant status in normal and diabetic rats.Results:Admistration of alcoholic extract of A.lamarekii at two dosage 250 and 500 rag/kg,p.o.did not showed any significant change in blood glucose level of normoglycemic rats(P>0.05).whereas,oral glucose tolerance test depicted reduction in blood glucose level(P<0.05).The streptozotocin-nicotinamide induced diabetic rats, significantly decreased the blood plasma glucose level(P<0.001) comparable to glibenclamide (10 mg/kg),restored the lipid profile and showed improvement in liver glycogen,body weight and antioxidant status in diabetic rats.Conclusions:Present finding demonstrated the significant antidiabetic activity of alcoholic leaves extract of.4.lamarekii. 关 键 词：Alangium lamarckii ANTIDIABETIC activity GLUCOSE tolerance test STREPTOZOTOCIN
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