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Antioxidant,antibacterial and cytotoxic effects of the phytochemicals of whole Leucas aspera extract

查看全文 作　　者：Md Atiar [1,2]Rahman;Md Saiful [1]Islam 高影响力作者 机构地区：[1]Department of Biochemistry and Molecular Biology,University of Chittagong,Chittagong-4331,Bangladesh;[2]Department of Biochemistry,School of Biochemistry,Genetics and Microbiology,University of KwaZulu-Natal.(Westville Campus),Durban 4000,South Africa高影响力机构 出　　处：《Asian Pacific Journal of Tropical Biomedicine》索引2013年第3卷第4期,共7页高影响力期刊 基　　金：Supported by Chittagong University Research Cell(Ref No.5194/Res/Dir/CU/2011) 摘　　要：Objective:To investigate the antioxidant,antibacterial and cytotoxic activity of whole Leucas aspera(Labiatae)(L.aspera)alcoholic extract.Methods:Whole L.aspera powder was extracted by absolute ethanol(99.50%).The ethanolic extract was subjected to antioxidant,antibacterial and brine shrimp lethality assay.Results:The extract showed potent radical scavenging effect(antioxidant)with IC_(50)value of(99.58±1.22)μg/mL which was significant(P<0.01)in comparison to ascorbic acid with IC_(50)value of(1.25±0.95)μg/mL.In case of antibacterial screening,the extract showed notable antibacterial effect against the tested microbial strains.Significant(P<0.05)zone of inhibitions against Gram positive Bacillus subtilis[(12.00±1.32)mm]and Bacillus megaterium[(13.00±1.50)mm],Staphylococcus aureus[(8.00±0.50)mm]and Gram negative Salmonella typhi[(6.00±0.50)mm],Salmonella paratyphi[(8.00±1.00)mm],Shigella dysenteriae[(9.00±1.32)mm]and Vibrio cholerae[(9.00±0.66)mm]was observed.In brine shrimp lethality bioassay,the extract showed the LC_(50)value as(181.68±2.15)μg/mL which was statistically significant(P<0.01)compared to positive control vincristine sulfate[LC_(50)=(0.76±0.04)μg/mL].Conclusions:The results demonstrate that the ethanolic extract of L.aspera could be used as antibacterial,pesticidal and various pharmacologic actives. 关 键 词：Leucas aspera RADICAL SCAVENGING ANTIBACTERIAL CYTOTOXIC PROBIT
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