Antimicrobial susceptibility patterns of Streptococcus pneumoniae over 6 years at Gondar University Hospital, Northwest Ethiopia

查看全文 作　　者：Belay [1]Anagaw;Mucheye [1]Gezachew;Fantahun [2,3]Biadgelgene;Berhanu [4]Anagaw;Tariku [5]Geleshe;Birke [5]Taddese;Birhanu [5]Getie;Mengistu [1]Endris;Andargachew [1,6]Mulu;Chandrashekhar [1]Unakal

机构地区：[1]Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar,Ethiopia;[2]Department of Microbiology, Immunology and Parasitology, College of Medicine and Health Sciences, Bahir Dar University,Bahir Dar, Ethiopia;[3]Institute of Medical Microbiology and Epidemiology of Infectious Diseases, Faculty of Medicine, University of Leipzig,Germany;[4]Science Faculty, Addis Ababa University,Addis Ababa, Ethiopia;[5]College of Medicine and Health Sciences, University of Gondar Teaching Hospital Laboratory, Bacteriology Section, University of Gondar,Ethiopia;[6]Institute of Virology, Faculty of Medicine, University of Leipzig,Germany

出　　处：《Asian Pacific Journal of Tropical Biomedicine》索引2013年第3卷第7期,共6页

基　　金：This work was supported by Research and Community Services of University of Gondar with Grant No.RPO/55/43/2008 摘　　要：Objective:To assess the magnitude and antimicrobial susceptibility patterns ofStreptococcus pneumoniaeisolates from various clinical specimens.Methods:A record based on retrospectivestudy was conducted at Gondar University Teaching Hospital from September 2007 to January 2012.All patients who visited Gondar University Hospital and provided clinical specimens(body fluids,discharge,swab and blood)for routine bacteriological culturing and antimicrobial susceptibilitytesting were taken for analysis.Clinical specimens were processed for bacterial culture accordingto the standard procedures.Antimicrobial susceptibility test for isolated organisms was doneusing agar disk diffusion method.The data were entered and analyzed using SPSS software version16 package.Results:One hundred and fifty threeStreptococcus pneumoniaewere isolated frompatients who visited Gondar University Teaching Hospital bacteriology laboratory for culture.Majority of the pneumococcal isolates were from inpatients[111(72.5%)],and 74(48.4%)were frombody fluids.Out of the total isolates,93(61%)were found to be resistant to at least one antibioticused for susceptibility testing.Forty eight(43.2%)of the isolates were multi-drug resistant(resistantto two or more drugs).The resistance rate noted for both ciprofloxacin 17(11.1%)and ceftriaxone15(9.8%)were alarming.Conclusions:High proportions of the isolates tend to be increasinglyresistant to the commonly prescribed drugs.The recommended drug of choice like ciprofloxacinand ceftriaxone were found to be less susceptible in the study area.Based on the findings,wetherefore recommend that antimicrobial agents should be inspected for acceptable activity beforethey are prescribed and administered empirically.Further study with a better design and surveyof antimicrobial susceptibility at large scale shoule be performed to draw advanced information. 关键词：STREPTOCOCCUS PNEUMONIAE ANTIMICROBIAL agents SUSCEPTIBILITY PATTERNS Gondar Ethiopia

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Antimicrobial susceptibility patterns of Streptococcus pneumoniae over 6 years at Gondar University Hospital, Northwest Ethiopia

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