Hepatoprotective activity of Musa paradisiaca on experimental animal models

查看全文 作　　者：Nirmala [1]M;Girija [1]K;Lakshman [1]K;Divya [1]T 机构地区：[1]Department of Pharmacognosy,PES College of Pharmacy 出　　处：《Asian Pacific Journal of Tropical Biomedicine》索引2012年第2卷第1期,共5页 摘　　要：Objective:To invesligale the hepatoprotective activity of stem of Musa paradisiaca(M.paradisiaca)in CCl_4 and paracetamol induced hepatotoxicity models in rats.Methods:Hepatoprotective activity of alcoholic and aqueous extracts of stem of M.paradisiaca was demonstrated by using two experimentally induced hepatotoxicity models.Results:Administration of hepatotoxins(CCl_4 and paracetamol)showed significant biochemical and histological deteriorations in the liver of experimental animals.Pretreatment with alcoholic extract(500 mg/kg),more significantly and to a lesser extent the alcoholic extract(250 mg/kg)and aqueous extract(500 mg/kg),reduced the elevated levels of the serum enzymes like serum glutamic-oxaloacetic transaminase(SCOT),serum glutamic pyruvic transaminase(SGPT),alkaline phosphatase(ALP)and bilirubin levels and alcoholic and aqueous extracts reversed the hepatic damage towards the normal,which further evidenced the hepatoprotective activity of stem of M.paradisiaca.Conclusions:The alcoholic extract at doses of 250 and 500 mg/kg,p.o.and aqueous extract at a dose of 500 mg/kg,p.o.of stem of M.paradisiaca have significant effect on the liver of CCl_4 and paracetamol induced hepatotoxicity animal models. 关 键 词：MUSA paradisiaca SGPT SGOT ALP Direct BILIRUBIN Total BILIRUBIN HISTOPATHOLOGY