In vivo anticancer activity of vanillin semicarbazone

查看全文 作　　者：Shaikh M Mohsin [1]Ali;M Abul Kalam [1]Azad;Mele [1]Jesmin;Shamim [1]Ahsan;M Mijanur [1]Rahman;Jahan Ara [2]Khanam;M Nazrul [3]Islam;Sha M Shahan [4]Shahriar

机构地区：[1]Department of Applied Chemistry and Chemical Engineering, University of Rajshahi;[2]Department of Biochemistry and Molecular Biology, University of Rajshahi;[3]Department of Chemistry, University of Chittagong;[4]Department of Food Science & Technology, Chittagong Veterinary and Animal Science University

出　　处：《Asian Pacific Journal of Tropical Biomedicine》索引2012年第2卷第6期,共5页

基　　金：financially supported by University Grants Commission of Bangladesh[grant No.6(76)/UGC/BK/Chemistry(9)/2007-2008/3268] 摘　　要：Objective:To evaluate the anticancer activity of vanillin semicarbazone(VSC) against Ehrlich ascites carcinoma(EAC) cells in Swiss albino mice.Methods:The compound VSC at three doses(5, 7.5 and 10 mg/kg i.p.) was administered into the intraperitoneal cavity of the EAC inoculated mice to observe its efficiency by studying the cell growth inhibition, reduction of tumour weight,enhancement of survival time as well as the changes in depleted hematological parameters. Allsuch parameters were also studied with a known standard drug bleomycin at the dose of 0.3 mg/kg(i.p.).Results:Among the doses studied, 10 mg/kg(i.p.) was found to be quite comparable in potency to that of bleomycin at the dose of 0.3 mg/kg(i.p.). The host toxic effects of VSC was found to be negligible.Conclusions:It can be concluded that VSC can therefore be considered as potent anticancer agent. 关键词：ANTICANCER activity Ehrlich ASCITES CARCINOMA Schiffbase

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In vivo anticancer activity of vanillin semicarbazone

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