Effect of morin, a flavonoid against DOCA-salt hypertensive rats:a dose dependent study

查看全文 作　　者：Prahalathan [1]P;Kumar [1]S;Raja [1]B

机构地区：[1]Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University

出　　处：《Asian Pacific Journal of Tropical Biomedicine》索引2012年第2卷第6期,共6页

基　　金：financially supported by Department of Science and Technology,New Delhi,India(grant No.SR/FT/LS-150/2008) 摘　　要：Objective:To determine the protective effect of morin, a flavonoid against deoxycorticosterone acetate(DOCA)-salt induced hypertension in male Wistar rats.Methods:Hypertension was induced in uninephrectomized rats by weekly twice subcutaneous injection of DOCA(25 mg/kg bw) and 1% NaCl in the drinking water for six consecutive weeks. Effect of morin against DOCA-salt induced hypertension was evaluated by measuring blood pressure and performing biochemical estimations and histopathological examination of renal tissues.Results:DOCA-salt hypertensive rats showed considerably increased systolic and diastolic blood pressure,serum hepatic marker enzyme activities such as aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatase(ALP) and gamma-glutamyl transpeptidase(GGT)and renal function markers(urea, uric acid and creatinine) in plasma. Oral administration of morin(25, 50 and 75 mg/kg bw) brought back all the above parameters to near normal level.Histopathology of kidney also confirmed the biochemical findings of this study. The effect at a dose of 50 mg/kg bw of morin was more pronounced than that of the other two doses(25 and 75 mg/kg bw).Conclusions:These findings indicate that morin exhibits strong antihypertensive effect against DOCA-salt induced hypertension. 关键词：MORIN Uninephrectomy DOCA-salt Oxidative stress Hypertension ANTIHYPERTENSIVE EFFECT Blood pressure

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Effect of morin, a flavonoid against DOCA-salt hypertensive rats:a dose dependent study

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